1.Medium and long-term follow-up outcome after arthroscopic repair of type II SLAP lesions with two Loops
Sunyu CHEN ; Jian LI ; Zhaohao XIAO ; Hongwu ZHUO ; Ling PAN
Clinical Medicine of China 2017;33(3):209-212
Objective To determine the medium-long term functional outcome of arthroscopic repair of type II SLAP lesions with two loops.Methods According to retrospective study,29 cases patients with arthroscopic repairs of isolated type II SLAP lesions were collected from March 2011 to June 2013,the mean patient age at the time of surgery was 31.8 years(range17 to 47 years).All patients with ground anchor suture,and through double loop knot technology to fix SLAP injury.Visual analogue scale(VAS),Kerlan-Jobe Orthopaedic Clinic(KJOC),Roche Shouder function Score(ROWE) were used to determine the function of shoulder joint.The shoulderjoint range of motion before treatment and post treatment were recorded,shoulder joint mobility was recorded,satisfaction survey was done,compared the preoperative and postoperative data to evaluate its clinical effect.Results All patients were available for follow-up of 2.7-5.2 years.Overall,functional outcome was improved from baseline compared with final follow-up for VAS scores((4.3±1.2) points vs.(1.5±0.8) points,t=5.435,P<0.05),KJOC scores((72.1±4.9) points vs.(92.8±5.4) points,t=5.921,P<0.01),and ROWE scores((54.1±12.4) points vs.(84.3±10.2) points,t=7.326,P<0.01).Only a minority of patients feel pain when they did srenuous exercise.According to satisfaction investigation of patients,patient satisfaction was reported in 89.7%,3 cases had not good results,they could not return to previous level of play,including 2 cases were athletes,1 case was not athlete.Conclusion There is no more persistent pain and dysfunction after surgery,a good or excellent medium-long term functional outcome can be anticipated after arthroscopic repair of type II SLAP lesions with two loops.
2.A human circulating immune cell landscape in aging and COVID-19.
Yingfeng ZHENG ; Xiuxing LIU ; Wenqing LE ; Lihui XIE ; He LI ; Wen WEN ; Si WANG ; Shuai MA ; Zhaohao HUANG ; Jinguo YE ; Wen SHI ; Yanxia YE ; Zunpeng LIU ; Moshi SONG ; Weiqi ZHANG ; Jing-Dong J HAN ; Juan Carlos Izpisua BELMONTE ; Chuanle XIAO ; Jing QU ; Hongyang WANG ; Guang-Hui LIU ; Wenru SU
Protein & Cell 2020;11(10):740-770
Age-associated changes in immune cells have been linked to an increased risk for infection. However, a global and detailed characterization of the changes that human circulating immune cells undergo with age is lacking. Here, we combined scRNA-seq, mass cytometry and scATAC-seq to compare immune cell types in peripheral blood collected from young and old subjects and patients with COVID-19. We found that the immune cell landscape was reprogrammed with age and was characterized by T cell polarization from naive and memory cells to effector, cytotoxic, exhausted and regulatory cells, along with increased late natural killer cells, age-associated B cells, inflammatory monocytes and age-associated dendritic cells. In addition, the expression of genes, which were implicated in coronavirus susceptibility, was upregulated in a cell subtype-specific manner with age. Notably, COVID-19 promoted age-induced immune cell polarization and gene expression related to inflammation and cellular senescence. Therefore, these findings suggest that a dysregulated immune system and increased gene expression associated with SARS-CoV-2 susceptibility may at least partially account for COVID-19 vulnerability in the elderly.
Adult
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Aged
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Aged, 80 and over
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Aging
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genetics
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immunology
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Betacoronavirus
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CD4-Positive T-Lymphocytes
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metabolism
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Cell Lineage
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Chromatin Assembly and Disassembly
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Coronavirus Infections
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immunology
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Cytokine Release Syndrome
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etiology
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immunology
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Cytokines
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biosynthesis
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genetics
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Disease Susceptibility
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Flow Cytometry
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methods
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Gene Expression Profiling
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Gene Expression Regulation, Developmental
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Gene Rearrangement
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Humans
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Immune System
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cytology
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growth & development
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immunology
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Immunocompetence
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genetics
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Inflammation
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genetics
;
immunology
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Mass Spectrometry
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methods
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Middle Aged
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Pandemics
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Pneumonia, Viral
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immunology
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Sequence Analysis, RNA
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Single-Cell Analysis
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Transcriptome
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Young Adult