Objective To investigate the diagnostic value of VCA-IgA and multilayer enhanced spiral CT(MESCT) in the diagnosis of nasopharyngeal carcinoma.Methods Retrospective analysed the data on serum VCA-IgA test and MESCT of 385 patients with suspected nasopharyngeal disease,and the results were confirmed by surgery and pathology.Comparatively analysed the two methods in differential diagnosis of nasopharyngeal carcinoma and benign diseases.Finally,calculated the sensivity,speficity,positive predictive value,negative predictive value and accuracy in diagnosis of nasopharyngeal carcinoma.Results The positive rate of serum VCA-IgA,MESCT and combination of those two methods in naospharyngeal carcinoma were significantly higher than those in nasopharyngeal benign disease(P<0.05);combination of the methods significantly improve the sensitivity and accuracy in diagnosis of nasopharyngeal carcinoma,the specificity was lower than VCA-IgA,higher than MESCT alone.Conclusion Combination of serum VCA-IgA and MESCT were excellent strategy for diagnosis of nasopharyngeal carcinoma.

OBJECTIVE: To assess hearing effect of ossicular chain reconstruction with titanium ossicular replacement prosthesis during mastoidectomy with synchronous ossiculoplasty in chronic middle ear disease. METHOD: Retrospective reviews were performed for 139 patients who had underwent mastoidectomy and tympanoplasty with titanium ossicular replacement prostheses at the same time between 2008 and 2011. The partial ossicular replacement prostheses (PORP) were used in 91 patients and the total ossicular replacement prostheses (TORP) were used in 48 patients respectively. All patients had follow-up for 2 to 5 years. The preoperative and postoperative mean air conduction and air-bone gaps(ABG) for the four frequencies (0.5, 1.0, 2.0 and 4.0 kHz) were evaluated. The improvement of mean air conduction and ABG over the same frequencies were measured. A postoperative ABG less than or equal to 20 dB was considered a successful operation. The hearing results of titanium PORP and TORP were compared. RESULT: The mean air conductions were (53.97 +/- 11.32)dB and (36.80 +/- 11.68) dB preoperatively and postoperatively in PORP group. The mean improvement in air conduction was (17.17 +/- 5.79)dB. The mean ABG was (31.84 +/- 6.17)dB and (15.13 +/- 7.22)dB preoperatively and postoperatively in PORP group. The mean improvement in ABG was (17.71 +/- 5.5)dB. The difference of hearing threshold between preoperative and postoperative had statistical significance (P < 0.01). The mean air conduction were (58.05 +/- 11.35)dB and (44.53 +/- 13.15)dB preoperatively and postoperatively in TORP group. The mean improvement in air conduction was (13.52 +/- 7.81)dB. The mean ABG; were (35.67 +/- 5.73)dB and (21.48 +/- 7.01)dB preoperatively and postoperatively for TORP group. The mean improvement of hearing threshold in ABG was (14.18 +/- 7.53)dB. The difference of hearing threshold between preoperative and postoperative had statistical significance (P < 0.01). ABG less than 20 dB after operationwas happened in 68.63% of the patients (74.73% for PORP and 54.17% for TORP). There was statistically significant difference between PORP and TORP (P < 0.05). CONCLUSION We conclude that titanium ossicular reconstruction during mastoidectomy with synchronous ossiculoplasty give stable and excellent hearing results. We obtained better results with PORP than with TORP.
Adolescent ; Adult ; Aged ; Child ; Female ; Follow-Up Studies ; Humans ; Male ; Mastoid ; surgery ; Middle Aged ; Ossicular Prosthesis ; Ossicular Replacement ; methods ; Retrospective Studies ; Titanium ; Treatment Outcome ; Tympanoplasty ; methods ; Young Adult