Objective To understand the current status of Oncomelania hupensis snails and the change rules,so as to pro?vide the evidence for formulating the snail control strategy. Methods The data of snails were collected and the factors influenc?ing the changes of snail status were investigated,and all the data were analyzed in Hailing District from 2007 to 2014. Results There were 18 environments with snails in 17 villages of 3 townships in Hailing District from 2007 to 2014. The snail area was 7.832 4 hm2. Among these environments and snail areas, 6 environments and 2.134 5 hm2, snail area were detected by the village snail investigation groups, and 12 environments and 5.697 9 hm2 snail area were detected by the township snail investigation groups. In addition, in 5 non?endemic villages, 3.126 3 hm2 snail area was found. In 2008, 2012 and 2013, a total of 2.274 0 hm2 snail area was found again. Conclusions In recent years,the snail situation rises again after schistosomiasis transmission has been interrupted. Therefore,this situation should be paid attention to.

High-consuming group is a special group which has good economic base, differmental culture and relgional belif customs. These patients alwanys need high quality medical service. How to integrate with these characteristics and make the nursing model of making patients' belife, moral ideas respcted, and rights proteded is a difficult problem. The author put forward we should rule nurse staff' s ethics and actions, provide a medical envionment from which can meet high-consuming patients physical and mental needs.

Objective To determine the mercury in seven kinds of algal plant drugs.Method The mercury in the samples was determined by the atomic fluorescence spectrometry after been digested by microwave.Results The detection limit of mercury was 0.045?g?L~(1).The relative standard deviation was 1.65% and the average recovery was 97.77%.Conclusion The method had the advantages of simple operation,higher precision,higher sensitivity and repeatability and was suitable for the determination of mercury in the algal plant drugs.

Objective To investigate the epidemiological characteristics of imported malaria in Hailing District ,Taizhou City,so as to provide the evidence for formulating the effective prevention and control strategy. Methods The network reports, questionnaires and epidemic reports of imported malaria cases in Hailing District from 2010 to 2015 were collected and analyzed retrospectively. Results From 2010 to 2015,totally 46 cases of imported malaria were reported,including 40 cases of falci?parum malaria(86.96%),4 cases of ovale malaria(8.70%),1 case of quartan malaria(2.17%)and 1 case of multi?infection of falciparum malaria and tertian malaria(2.17%). No seasonal trend of time of the disease onset was observed. All the patients were return abroad with clear residence histories in malaria epidemic areas. The average time from disease onset to definite diag?nosis was 2 d and 8 patients were definitely diagnosed within 24 h. All the 46 patients were cured. Conclusion All the malaria cases reported were imported cases in Hailing District in the last five years. Effective prevention and control measures are the key to the malaria elimination.

OBJECTIVE:To study the effects of aripiprazole on PC12 cell injury induced by amyloid β-protein(Aβ25-35)and its mechanism. METHODS:PC12 cells were randomized into normal control group,model group (20 μmol/L Aβ25-35),aripiprazole low-concentration,medium-concentration and high-concentration groups(5,10,20 μmol/L aripiprazole+20 μmol/L Aβ25-35). These groups were cultured with culture medium containing relevant medicine for 48 h,with 6 wells in each group. The viability(optical density value)of PC12 cell was measured by MTT assay,and PC12 cell apoptosis was measured by Hoechst staining. The activi-ties of Caspase-3 and Caspase-9 were determined by spectrophotometry. The protein expression of Bcl-2,Bax and PI3K and the phosphorylation of Akt were assayed by Western blot assay. RESULTS:Compared with normal control group,optical density value of model group was decreased while apoptotic rate was increased;the activities of Caspase-3 and Caspase-9,and the protein expres-sion of Bax were increased;the protein expression of Bcl-2 and PI3K,the phosphorylation of Akt were decreased(P<0.01). Com-pared with model group,optical density value of aripiprazole low-concentration,medium-concentration and high-concentration groups were increased,while apoptotic rate and the activities of Caspase-3 and Caspase-9 were decreased;the protein expression of Bcl-2 and PI3K and the phosphorylation of Akt were enhanced;while the protein expression of Bax were decreased in aripiprazole medium-concentration and high-concentration groups(P<0.05 or P<0.01). CONCLUSIONS:Aripiprazole can suppress cell apop-tosis of PC12 cell induced by Aβ25-35,which is related to activating PI3K/Akt signal pathway.

Aquaporins are small integral membrane proteins that selectively transport water and some small solutes in mammals, plants and lower organisms. Continued studies of the aquaporins are providing detailed tissue localization and the important physiological roles of aquaporins in urinary, respiratory, digestive and nervous systems. Based on the importance of aquaporin studies in the field of structural chemistry in biomembranes, American scientist Peter Agre won the 2003 Chemistry Nobel Prize for the discovery of water channels.

Bilateral vasovasostomy was performed on 14 male rabbits which received a vasectomy 12 months ago. After 3 months, the rabbits were mated with female rabbits in a course of two months in order to observe the restoration of fertility. They were divided into vasovasostomy fertility group(VFG)and vasovasostomy infertility group(VIG), 7 rabbits, each according to their fertility. 8 rabbits that received a vasectomy only were designated as vasectomy group(VG), and 9 as sham-operation group(SOG), both (VG & SG) served as control. The results showed, (1)the value of sperm density in VFG was significantly lower than that in SOG, but markedly higher than that in VIG(P

OBJECTIVE:To improve the rational compatible use of Chinese patent medicines with western medicines. METHODS:A total of 24 000 prescriptions were randomly sampled from July 10th to July 15th in 2006 for an analysis of the compatibility of Chinese patent medicines containing Salvia miltiorrhiza,Radix et Rhizoma Glycyrrhizae,Radix et Rhizoma Rhei with western medicines.RESULTS:Of the total 24 000 prescriptions analyzed,6 830(or 3 213 patients) involved combined use of Chinese patent medicines with western medicines,of which,the irrational combination for Salvia miltiorrhiza-contained,Radix et Rhizoma Glycyrrhizae-contained and Radix et Rhizoma Rhei-contained Chinese medicines with western medicines totalled 128,118 and 16 cases respectively.CONCLUSION:When the Chinese patent medicines being used in combination with western medicines,their physicochemical and pharmacological properties should be taken into fully consideration so as to achieve rational combination.

Enterovirus 71(EV71),a member of human enterovirus family,was first isolated from faeces of a central nervous system infected infant in 1969.In recent 30 years,EV71 outbreaks every 2-3 years in the Asia-Pacific regions,and is the main pathogen causing severe hand-foot-mouth disease(HFMD).Severe HFMD caused by EV71 involves in central nervous system and respiratory system disorder.In general,EV71 associated complication is related to the viral invasion of central nervous system,leads to pulmonary edema or pulmonary hemorrhage.It is of great significance to study the clinical features and pathogenesis of EV71 infection,and then take positive and effective measures to block the occurrence of its complications.

objectives To provide the reference for the Research & Development departments of hospitals by analyzing the quantity of publications and their cited status for the top 20 hospitals in SCl and MEDLINE.and top 100 hospitals in domestic publications in 2006.Methotis The number of publications and their cited times for the first 20 hospitals in SCI and MEDLINE.and the top 100 hospitals in domestic publications in 2006 were analyzed with bibliometric analysis.Results In 2006.the average increased ratio of publications in SCI for top 20 hospitals was 47.58%.but the number of articles in MEDUNE WaS decreased.For top 100 hospitals.the increased number of domestic publications was 71.25,the number of cited publications WaS increased 160.14.Conclusions The SCI publications from top 20 hospitals increased sharply,but publicatiOils indexed by MEDLINE decreased respectively.