2.Biomechanical study of single - level anterior cervical intervertebral decompression and fusion with plating uniplate and orion
Feng ZHANG ; Jianhua LU ; Jian ZHAO
Orthopedic Journal of China 2006;0(19):-
0.05).[Conclusion]The stability of the single - level anterior cervical intervertebral decompression and fusion with plating Uniplate is satisfactory.Uniplate is valuable in clinic,furthermore,it is relatively simple to operate.
3.The role of apoptosis in pancreatic cancer therapy
Xiangxuan ZHAO ; Feng WEN ; Zaiming LU
Practical Oncology Journal 2016;30(4):375-379
Pancreatic adenocarcinoma ( PAC) is still a refractory human digest malignancies due to multi-faceted causes ,late diagnosis and insensitive to traditional chemo -and radio-therapy .Resistance to apoptosis could be one of the most relevant mechanisms for PAC to escape any non -surgical therapy .This review aims to clear up the main deregulated apoptosis signal pathways over the years and to find out the abnormal molecule tar -get(s),and therefore,provide novel concepts for PAC molecular targeting therapy .
4.CTLA-4 gene polymorphism and protein expression and apoptosis of peripheral blood lymphocytes from idiopathic nephrotic syndrome children with the pathologic type of mesangial proliferative glomerulonephritis.
Feng-ying WANG ; Si-guang LU ; Tong ZHAO
Chinese Journal of Pediatrics 2007;45(8):633-634
Antigens, CD
;
genetics
;
metabolism
;
Apoptosis
;
genetics
;
CTLA-4 Antigen
;
Child
;
Female
;
Glomerulonephritis
;
genetics
;
pathology
;
Humans
;
Male
;
Nephrosis, Lipoid
;
genetics
;
pathology
;
Polymorphism, Genetic
5.A giant solitary fibrous tumor of the pleura.
Lu-feng ZHAO ; Ying CHAI ; Li-jian HUANG
Chinese Medical Journal 2013;126(15):2999-2999
6.Changes of argiuine vaso-pression in blood and cerebral spinal fluid(CSF)in patients with severe brain injury after treated with mild hypothermia
Hui ZHAO ; Weidong HANG ; Feng LU ; Weiming WANG ;
Chinese Journal of Emergency Medicine 2006;0(09):-
Objective To study the changes of blood arginine vaso-pression(AVP)levels in patients with severe brain injury after treated with mild hypotherima.Methods Seventy-eight patients with severe brain injury were divided into mild hypothermia(33~35℃)group and normothermia group.The blood AVP levels and CSF AVP levels were determined at the third and the seventh day after brain injury.Results The AVP levels in blood and CSF of mild hypothermia group were lower than those of the normothermia group at the third and seventh day after brain injury(P<0.05).According to GOS,prognosis of the mild hypothermia group was better than that of the nonnotbcrmia group(P<0.05).Conclusion The mild hypothermia treatment may have inhibitive effects on the production of blood AVP,CSF AVP,and brain edema.Mild hypothermia is an effective method in the treatment of acute severe brain iniury in reducing the mortality and in increasing the survival rate.
7.Effects of apelin-13 on myocardium metabolism in diabetic rats
Mengze DU ; Jinghui FENG ; Hang ZHAO ; Ying LU ; Xiuping WU
Chinese Journal of Geriatrics 2017;36(4):454-458
Objectives To investigate the effects of Apelin 13 on myocardial metabolism in diabetic rats.Methods A total of 40 male Wister rats were randomly divided into normal control group (NC,n=8) and experimental group (n =32).Diabetic rats model were induced by high-sugar and high-fat diet combined with low-dose intraperitoneal injection of streptozotocin (STZ).The wellestablished 28 diabetic model rats were randomly divided into diabetic model group (DM,n=14) and apelin-13 treated group (n=14).In the Apelin-13 group,diabetic rats were administered Apelin-13 [0.1 μmol/(kg · d)]by intraperitoneal injection for 10 weeks,while the control group and diabetic model group were given an equal volume of 0.9% NaCl.At the end of the 10th week,all rats were sacrificed after fasting glucose measurement.Levels of serum free fatty acids (FFA) and myocardial FFA were measured by ELISA.Expression of myocardial glucose transporter member 4 (GLUT4) were detected by immunohistochemistry.The mRNA expressions of myocardial PPARα,CD36 and CPT-1 were detected by real-time fluorescence quantitative PCR.Results Fasting blood glucose,serum FFA and myocardial FFA were significantly higher in DM group than in NC group (all P< 0.05).The level of plasma glucose and myocardial FFA were significant lower(P>0.05) in Apelin-13 treated group than in DM group;but serum FFA was not significantly lower(P<0.05).The mRNA expressions of PPARα,CD36,CPT-1 in cardiac myocyte were higher in DM group and Apelin-13 treated group than in control(P<0.05),and lower in Apelin-13 treated group than in DM group(P< 0.05).The expression of myocardial GLUT4 was significantly lower in DM group(1.138±0.316)and in Apelin-13-treated group (4.631 ± 1.832) than in NC group(9.132 ± 2.156),(F=65.507,P< 0.05),and higher in Apelin-13-treated group than in DM group(P<0.05).Conclusions Apelin-13 increases myocardial expression of GLUT4,improves utilization of FFA,and it can effectively reduce the expression of PPARα,CD36 and CPT-1.Therefore,it may play a vital role in the improvement of myocardial metabolism in diabetic rats.
8.Study advances on the roles of apoptosis in hepatocellular carcinoma therapy
Xiangxuan ZHAO ; Feng WEN ; Xiaonan MAO ; Zaiming LU
Practical Oncology Journal 2016;30(5):448-452
Hepatocellular carcinoma ( HCC ) is one of the commonest malignant tumors in China .The therapeutic effects of conventional therapies including surgery resection at early stage ,chemotherapy or radiothera-py are greatly less than expected .One of the most possible reasons is the blockage of apoptosis in HCC cells .This review collects literatures about the studies on the roles of key signal pathways including RA ,STAT3,PDT,p53,β-catenin,TRAIL,microRNA and RAS in HCC therapy .This study may contribute greatly to providing outline in-sights for using apoptosis induction in liver cancer therapy .We hope it can promote the development liver cancer therapy in China .
9.The relationship between TGF-?_1 mRNA and acute rejection of small intestinal allografts in rats
Feng ZHAO ; Lihong LU ; Jun SHAO ; Jinlin YIN
Chinese Journal of Current Advances in General Surgery 1999;0(02):-
Objective:To investigate the relationship between TGF-? 1mRNA and acute rejection of small intestinal allografts in rats.Methods:Rats were divided into two groups.Group Ⅰ:Wistar→SD Small intestinal transplantation,Group Ⅱ:Wistar→SD Small intestinal transplantation+CsA.The pathologic changes of allografts at 3 rdday,5 thday,7 thday after operation investigated and the transcription of IL-2,IFN- ?,and TGF-? 1mRNA was detected by semi-quantity RT-PCR.Results:Pathologic change:There was acute rejection at 3 rdday,and became severe at 7 thday in group Ⅰ,and there was only slight rejection at 7 thday in groupⅡ.TIFN-?、IL-2mRNA obviously increased after operation in groupⅠ.But they increased only a little in group Ⅱ.It had statistical significance between the two groups(P
10.Analyses of toxicology results in the ifre and non-ifre related carbon monoxide poisoning
Xuesong LU ; Feng LI ; Yao ZHAO ; Han ZHANG
Chinese Journal of Forensic Medicine 2016;31(4):384-386
Objective Explore the individual difference in carbon monoxide (CO) poisoning and analyze whether females were be more resistant to CO poisoning.Methods We collected 207 cases of CO poisoning deaths, and then we analyzed the Carbonyl Hemoglobin (COHb) results sorted by different sources of CO.Results The source of CO had significant impact on the fatal COHb level, but gender was not significant in affecting COHb level. In addition, it is possible that children and elders were less resistant to COHb than adults.