Substantial evidence supports the relationship between chronic inflammation and cancer development. Numerous studies suggest that chronic inflammatory disease, such as periodontitis, contributes to head and neck squamous cell carcinoma development. Oral squamous cell carcinoma (OSCC) is the most common malignant tumor in the oral and maxillofacial regions. Porphyromonas gingivalis, one of the most important pathogens in association with periodontal disease, might have a potential correlation with OSCC. Along with the development of molecular biological techniques, the association between Porphyromonas gingivalis and OSCC has been greatly emphasized in recent years. This review summarizes the association between these variables and the potential mechanisms involved in such relationship.
Carcinoma, Squamous Cell ; pathology ; Humans ; Mouth Neoplasms ; pathology ; Periodontal Diseases ; Periodontitis ; Porphyromonas gingivalis ; Research

Clinicians should assume the responsibility of nutritional therapy for satisfactory outcomes. They should master knowledge on nutritional metabolism, and participate in the administration of nutritional support. Clinicians should be acquainted with new concepts and standardized techniques in this field, such as different requirement of energy, understanding of early nutritional support, and optimal regimens of enteral or parenteral nutrition.
China ; Enteral Nutrition ; Humans ; Nutritional Support ; Parenteral Nutrition

Cardiovascular Diseases ; etiology ; prevention & control ; Humans ; Hypertension ; complications ; Risk Factors

Humans ; Metabolic Syndrome

Child ; Humans ; Tachycardia ; physiopathology ; therapy

Objective To study the effect of Shuxuening injection on treatment of left ventricular diastolic dysfunction.Methods Ninety cases of left ventricular diastolic dysfunction were divided into control group and test group randomly,45 cases for each group.Both groups were treated with standard management and the treatment group was given Shuxuening injection(20 mL) additionally for 2 weeks.E/A ratio,peak E,peak A,LVEF were observed before and after treatment.Result The clinical symptoms of the two groups were all improved after treatment.The test group had a higher overall effective rate than the control group.The ventricular diastolic function paramenters(E/A ratio,peak E,peak A,LVEF) in the test group were much better than that in the control group.Conclusion Shuxuening injection can improve the clinical symptoms and signs of left ventricular diastolic dysfunction.

Objective To compare and analyze the difference of ?-tubulin and aurora-A expression in human cervical cancer cells (CasKi ) and immortalized human cervical squamous H8 cells with positive HPV16 E6E7.Methods Difference of ?-tubulin and aurora-A expression in CasKi and H8 cells was analyzed by showing the fluorescence intensity of ?-tubulin with indirect immunofluorescence.Expression level of aurora-A mRNA was detected by RT-PCR.Expression level of ?-tubulin and aurora-A in CasKi and H8 cells was semi-quantitatively analyzed by Western blot.Results The immunofluorescence signal of ?-tubulin was stronger in Caski cells than in H8 cells (57.78?3.13 vs 37.37?2.37,P

Immunohistochemical method, immuno-electron microscopic technique and radioimmunoassay (RIA) were used for the demonstration of ?-endorphin-like immunoreactivity (?-EP-IR) and of the circadian variation of the ?-EP-IR level in rat pituitary. ?-ER-IR was located in all cells of the pituitary intermediate lobe. A few ?-ER-IR-positive cells were scattered in the anterior lobe, and no positive immunoreactivity was found in the posterior lobe. The controls were negative. Under electron microscope, ?-ER-IR-positive dense particles were mostly located in the secretion granules, and a few of them were scattered freely in the cytoplasm of the intermediate lobe cells. Both pituitary ?-EP-IR concentration and the basal pain threshold in rat showed circadian variations in the experiment done at 4-hr intervals over a 24-hr period (P

Bicuspid aortic valve(BAV) is one of the most common congenital cardiovascular malformations,affecting 1% to 2% of the population.BAV may be sporadic or familial.BAV is likely a multiple genetic disorder based on the study of heritability and identification of pathogenic genes and potential candidate genes.With increasing studies of related genes of BAV,early intervention and gene therapy of BAV and associated complications may be likely in the near future.

Objective To investigate different factors related to fetal growth restriction (FGR) and to find out the possible causes of FGR with unclear etiologies. Methods Sixty-three women who were suspected of FGR during pregnancy between March 2002 and March 2003 were included in this study. Their age, body mass index (BMI) before pregnancy, and gestational weeks were recorded at the time when they were first diagnosed . Haemoglobin levels, haematocrit (HCT) ,TORCH, anticardiolipin antibody (ACA) , 50 gram glucose challenge test (50g GCT) , 75 gram oral glucose tolerance test (75g OGTT) , leptin levels, systolic/diastolic (S/D) ratio by color doppler monitor and chlamydia trachomatis (CT) were detected and urine culture was done in these groups during the same period. The gestational week, birth weight, body length and the gender were recorded at the delivery period. The FGR group was then divided into two subgroups according to the birth weights: study A group whose birth weights were lower than 10th% of the birth weights at the given gestational weeks (29 cases) and study B group whose birth weights were beyond 10th% (34 cases). The chromosome, leptin, C-peptide, insulin and TORCH of umbilical blood were measured at delivery. The other 25 normal pregnant women were included as control and the same tests were performed accordingly. Results The fasting glucose and the third hour's glucose of 75 gram oral glucose tolerance test of study A were( 3. 8 ?0, 6) mmol/L and (4. 5 ?1. 1) mmol/L. The fetal lepin, C-peptide, and insulin were (7.3 ? 5. 2) ng/ml, (0. 5 ? 0. 3) nmol/L and (2. 3 ? 1. 3 ) mU/L The S/D ratio of umbilical artery, maternal and fetal infection rate of CMV, positive rate of ACA-IgM and the rate of asymptomatic bacteriuria were 3.06, 20.7%, 24.1%, 44.8% and 62.1% respectively. The fasting glucose and the third hour's glucose of 75 gram oral glucose tolerance test of study B were (4. 4 ? 0. 7) mmol/L and (4. 6 ? 1. 1 ) mmol/L. The fetal lepin, C-peptide, and insulin were ( 13. 2 ? 11. 3 ) ng/ml, (0. 7 ? 0. 4) nmol/L and (4.3 ? 3.3) mU/L The S/D ratio of umbilical artery, maternal and fetal infection rate of CMV, positive rate of ACA-IgM and the rate of asymptomatic bacteriuria were 2. 63, 2. 9% , 0% , 5.9% and 44. 1% respectively. The fasting glucose and the third hour's glucose of 75 gram oral glucose tolerance test in control were (4. 3 ? 0. 7) mmol/L and (5. 3 ? 1.2) mmol/L. The fetal lepin, C-peptide, and insulin were( 20. 5 ? 12. 0) ng/ml, (1. 0 ? 0. 4) nmol/L and ( 6. 3 ? 4. 0) mU/L The S/D ratio of umbilical artery, maternal and fetal infection rate of CMV, positive rate of ACA-IgM and the rate of the asymptomatic bacteriuria were 2. 80, 0, 0, 0 and 24. 0% respectively. All these items were significantly higher in study A than those in the control (P