1.Advancement in the study of pathogenesis of polymyositis/dermatomyositis
Fudan University Journal of Medical Sciences 2009;36(6):779-781
Polymyositis (PM) and dermatomyositis (DM) are inflammatory myopathies and slowly advanced of unknown etiology that affect the skeletal muscles.With the advancement of the constant research on the disease and use of new technology,people have a penetrating realization about the pathogenesis. The disease is thought to be associated with autoimmune as well as nonimmune mechanism. By now, there is no overall summary on the newest advancement of the pathogenesis.We summarized the progress on the pathogenesis of the disease in order to make it more clear to physicians.
2.The value of serum progesterone level in the early diagnosis of ectopic pregnancy
Chinese Journal of Postgraduates of Medicine 2009;32(9):18-19
Objective To explore the value of serum progesterone level in the early diagnosis of ectopie pregnancy. Method Serum progesterone levels were measured prospectively in 36 patients with ectapic pregnancy and 30 women with normal intrauterine pregnancy. Results The serum progesterone level in ectopic pregnancy [(5.12± 3.98) μg/L] was lower than that in normal intrauterine pregnancy [(25.23±6.81) μg/L]. Recommended 11 μg/L as the cutoff point of progesterone concentrations in diagnosis of ectopie pregnancy, the sensitivity rate was 91.7%(33/36), specificity rate was 93.3%(28/30),missed diagnosis rate was 8.3% (3/36) in the diagnosis of eetopie pregnancy. Conclusion The serum progesterone detection can be considered as an early diagnostic method of eetopie pregnancy because it can be measured easily and quickly.
3.The clinical effect of Misoprostol promoting cervical mature for before abortion
China Pharmacist 2014;(5):859-860,870
Objective:Objective To investigate the clinical effect of Misoprostol promoting cervical mature for before abortion . Method:8 patients of induced abortion operation were enrolled in our hospital from January 2013 to January 2012 , and were randomly divided into observation group and control group, each group had 124 cases, the observation group was given misoprostol which placed in cvaginal fornix preoperative , and control group without prompting cervical ripening drug. Observation of cervical dilatation, degree of pain, operation time and bleeding volume in two groups of patients. Result: The efficiency rate of observation group was 96. 8%, significantly higher than 82. 3% in the control group, the difference was statistically significant (P<0. 05);there were 100 cases of painless in the observation group , and 51 cases in control group, the degree of pain in the observation group were obviously improved than the control group , the difference was statistically significant (P<0. 05);,operation time of treatment group was shorter than the control group, the amount of bleeding surgery was significantly lower than the control group, the differences were statistically significant (P<0. 05). Conclusion:Misoprostol is given before induced abortion , can relax cervical effectively, shorten operation time, reduce the patients' pain, reduce the difficulty of operation, increase the safety of operation , is worth the clinical promotion.
4.An automated method for assessment of sublingual microcirculatory perfusion based on videos.
Chinese Journal of Medical Instrumentation 2014;38(4):251-254
OBJECTIVEThe assessment result of microcirculatory perfusion provides significant evidence for the detection of microcirculatory alterations in sepsis patients, and functional capillary density based on vessel segmentation can reflect microcirculatory perfusion effectively.
METHODSFirst, preprocessing comprise operations to improve the quality of images in order to maximize the contrast between background and vessels. Secondly, adaptive local thresholding is used for initial segmentation to get the general vessel region. Finally, post-processing technique reduces the image artifacts and links the vessel fragment, and then functional capillary density is calculated based on the segmentation results.
RESULTSSeveral sublingual microcirculatory data have been tested, and the agreement between the results by AVA and the proposed algorithm reached up to 92%.
CONCLUSIONSThe method can realize automated assessment of sublingual microcirculatory perfusion rapidly and accurately, and has strong clinical value.
Algorithms ; Image Processing, Computer-Assisted ; methods ; Microcirculation ; Mouth Floor ; blood supply
5.Development of ECG Simulation Training System Based on PC
Chinese Medical Equipment Journal 1989;0(01):-
Objective To develop a kind of system of simulation and training on ECG for studying ,training and assessing of biomedical engineer. Methods The simulation training system was designed based on PC. In the hardware system, ADuC848 SCM was adopted as the primary controller, QuickStart exploration platform was used to develop firmware, and intelligent assessing system was explored by C++ Builder. Results Biomedical Engineer could be trained, checked and evaluated by the system. Conclusion The system, combining practice and examination, pays attention to basic skill training and thus improves studying efficiency.
6.Analysis on Sample Inspection of TCM Decoction Pieces During 2014-2015 in Huguosi TCM Hospital Affiliated to Beijing University of Chinese Medicine
Chinese Journal of Information on Traditional Chinese Medicine 2017;24(6):123-125
Objective To provide references for improving the quality of TCM decoction pieces through the analysis on sample inspection of TCM decoction pieces of Huguosi TCM Hospital of Beijing University of Chinese Medicine (hereinafter referred to as our hospital). Methods In our hospital from January 2014 to December 2015, TCM decoction pieces with problems in this sample inspection were categorized according to reasons. Results Quality problems found in the sample inspection were categorized into 3 types, i.e. collection and preparation (69.79%), storage (20.93%) and other problems (9.31%). Cutting in collection and preparation (13.95%), worming in storage (9.30%) and breaking/crumbing (6.98%) were the most obvious problems. Conclusion Strengthening the management of procurement acceptance, strict control of storage and storage conditions, and paying attention to the use of other aspects of management can improve the quality of TCM decoction pieces.
7.Zinc on cell proliferation and oifferentiation
Yang LV ; Zhao LV ; Jinghai LV ; Jingying ZHANG
International Journal of Biomedical Engineering 2011;34(5):318-320
Zinc is essential for cell proliferation and differentiation,especially for the regulation of DNA synthesis and mitosis.On the molecular level,it is a structural constituent of a great number of proteins including enzymes of cellular signaling pathways and transcription factors.Zinc can modulate cellular signal recognition,second messenger metabolism,protein kinase and protein phosphatase activities.It may stimulate or inhibit activities of transcription factors,and it may as well be used as a second messenger involved in cell signaling regulation.
8.Relevant factors and preventive strategy for recurrent lumbar disc herniation
You LV ; Hanping ZHAO ; Peijia LI
Orthopedic Journal of China 2006;0(03):-
[Objective]To analyze and evaluate the relevant factors of recurrent lumbar disc herniation for providing strategy of prevention of this syndrome.[Method]Sixteen cases of recurrent lumbar disc herniation were analyzed according to medical history,physical examination and image examination before re-operation and the primary operation,and all the patients received exploration during operation.[Result]The relevant factors of recurrent lumbar disc herniation were as follows:the extent of disc degeneration,the stability of lumbar spine,the time of getting out of bed after primary operation and the weight of the patients.[Conclusion]Besides iatrogenic factors,there are several factors related to recurrent lumbar disc herniation,including the characteristics of disc and lumbar spine,as well as the compliance of patients.To remove these factors is the main preventive strategy of recurrent lumbar disc herniation.
9.Surgical treatment for recurrent lumbar disc herniation
You LV ; Hanping ZHAO ; Peijia LI
Orthopedic Journal of China 2006;0(11):-
[Objective]To investigate the surgical treatment of recurrent lumbar disc herniation. [Methods]A total of 17 patients with recurrent lumbar disc herniation were grouped into stable,unstable and severe unstable groups according to the dynamic X-ray film. Patients in stable group and unstable group were treated with open-window discectomy, and those of severe unstable group were treated with full laminectomy, decompression, pedicle screw fixation and fusion. JOA and VAS system were used to follow up before and after operation. Statistic analysis was performed between the stable and unstable groups in pain score and recovery rate.[Results]All the patients were followed up for 3 month to 3 years. The average JOA score was 4.94 before operation, and 12.18 at follow-up,with an average recovery rate of 71.74%. There was no statistic difference between stable group and unstable group in recovery rate.[Conclusion]For patients with spinal instability and chief complaint of leg symptom, reoperative treatment for recurrent lumbar disc herniation can be done with open-window discectomy which may offer good outcome.
10.Construction of eukaryotic expression carrier of recombinant pcDNA3.1-hBMP-7 and transfection into bone marrow stromal cells of rabbit
Zhen XUE ; Songcen LV ; Jindong ZHAO
Orthopedic Journal of China 2006;0(20):-
[Objective]To construct arecombinant eukaryotic expression plasmid carrying human BMP-7 gene which was transfected into bone marrow stromal cells(BMSCs) in vitro and expressed.[Method]Clone human BMP-7 cDNA from a Chinese woman placenta was recombinanted with plasmid pcDNA3.1,to construct eukaryotic expression carrier of recombinaut pcDNA3.1-hBMP-7.The BMSCs were isolated from rabbit bone marrow and cultured in vitro.They were divided into three groups: pcDNA3.1-hBMP-7 transduced group;pcDNA3.1 transduced group;untransduced group.The expression of hBMP-7 was detected by RT-PCR,Immuneohistochemistry.ALP,Collogen,Osteocalcin production were detected.[Result]The pcDNA3.1-hBMP-7 transduced BMSCs expressed hBMP-7 at both mRNA and protein levels.ALP activity was detected in pcDNA3.1-hBMP-7 transduced cells from day 2 to day 10,peaking on day 8.Collogen,osteocalcin production were elevated significantly too(P