Nowadays, modern information technology is rapidly developing; traditional novelty assessment service could not satisfy users' demands. The paper introduces an online application and management information system for medical research novelty assessment innovated of Zhuhai Health Information Center, including its background of exploration, system functions and application effects. Using this system to provide service for users could not only promote the efficiency and convenience but also provide new space of development for novelty assessment work.

Aim To investigate the effect of probucol on reverse cholesterol transport from macrophage to feces in vivo,serum lipid profiles of mice were tested before and after probucol administration for 4 weeks,and the 3H-contents in serum,liver and feces in mice were quantitated after 24 hours intraperitoneally injected macrophages which were labeled with 3H cholesterol.Methods 32 C57BL/6 mice were treated with different probucol(0,0.1%,0.5%,1% W/W)in chow diet for 4 weeks,then these mice were injected intraperitoneally with RAW264.7 macrophages(0.5 ml?mice,cells 5.0?106 with 6.2?106 cpm)which were loaded with cholesterol by incubation with acetylated LDL,labeled with 3H-cholesterol.Serum profiles were quantitated by enzymatic method;serum and liver tissues were harvested at 24th hour,feces were collected(0~24 hs),and all were analyzed for tracer counts(all were expressed as the percentage of the total injected counts per minute).Results After 4 weeks 0.1% probucol administration,the levels of total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C)decreased markedly by 34.3%,52.8%,(P

Objective To investigate the expression and prognostic value of serum antimicrobial peptide LL37 and human soluble scavenger receptor cysteine-rich domain-containing protein(SSC5D)in elderly patients with chronic heart failure(CHF).Methods A total of 100 CHF patients admitted to Suzhou Kowloon Hospital Affiliated to Shanghai Jiao Tong University School of Medicine from January 2017 to January 2022 were selected as the CHF group.According to the prognosis,these patients were divided into good group(n=60)and poor prognosis group(n=40).Another 100 healthy examinees were selected as the control group.Enzyme-linked immunosorbent assay was used to detect serum levels of LL37 and SSC5D.The differences in serum LL37 and SSC5D levels between CHF group and control group were compared.Spearman correlation analysis was used to analyze the correlation between serum LL37 and SSC5D.Kaplan-Meier survival curve was used to analyze the relationship between serum LL37 and SSC5D expression and the prognosis of CHF patients.COX regression analysis was used to analyze the factors affecting the prognosis of CHF patients.ROC curve was used to analyze the predictive value of serum LL37 and SSC5D for poor prognosis in elderly CHF patients.Result The levels of serum LL37(771.38±158.25 ng/ml)and SSC5D(15 789.35±1 306.25 pg/ml)in CHF group were higher than those in control group(526.23±115.58 ng/ml,8 938.72±858.29 pg/ml),and the differences were significant(t=12.510,43.830,all P＜0.001).Spearman correlation analysis showed that there was a significant positive correlation between serum LL37 and SSC5D in CHF patients(r=0.629,P＜0.001).The serum LL37 and SSC5D levels in CHF patients were positively correlated with NYHA cardiac function classification(r=0.776,0.751,all P＜0.001).The survival rate of the high-level LL37 group was lower than that of the low-level LL37 group(38.18％vs 86.67％),and the difference was significant(Log rankx2=24.242,P＜0.001).The survival rate of the high level SSC5D group was lower than that of the low level SSC5D group(37.74％vs 85.10％),and the difference was significant(Log rank x2=23.291,P＜0.001).Compared with the good prognosis group,the poor prognosis group had a higher proportion of patients over 70 years old,proportion of patients with NYHA cardiac function class Ⅲ+Ⅳ,and serum LL37 and SSC5D levels,and the differences were significant(x2=10.774,4.118,t=4.723,14.059,all P＜0.05).Multivariate COX analysis showed that age＞70 years(OR=1.515,95％CI:1.224～1.858),NYHA cardiac function class Ⅲ+Ⅳ(OR=1.236,95％CI:1.198～1.963),high level of LL37(OR=1.705,95％CI:1.163～2.582)and high level of SSC5D(OR=1.591,95％C1:1.052～1.916)were independent risk factors for the prognosis of CHF patients.ROC curve analysis showed that the area under the curve of serum LL37 combined with SSC5D for predicting poor prognosis of CHF in the elderly was larger than that of serum LL37 and SSC5D alone,and the differences were significant(Z=2.834,2.168,P=0.005,0.030).Conclusion The serum LL37 and SSC5D levels are increased in patients with CHF,and both are risk factors for poor prognosis in patients with CHF,which can be used as clinical indicators to evaluate the prognosis of CHF.