1.Quality of life and its related factors among left-behind children in Shandong and Sichuan provinces
Feifei GAO ; Zhanliang GAO ; Meijie DENG
Chongqing Medicine 2015;(16):2242-2244
Objective To explore the quality of life and its related factors among left‐behind children in Shandong and Si‐chuan provinces .Methods The cluster sampling method was used to select the study participants and thus each 3 rural primary schools were randomly chosen as the study sites in Shandong and Sichuan provinces .t‐test ,χ2 test and rank sum test were employed to perform univariate analysis ,and multivariate analysis was conducted using multiple linear regression .Results In this study ,there were totally 1804 participants with 778 left‐behind ones .There was statistical difference between left‐behind children and average children in each aspects of quality of life and the total score(P<0 .05) .Multiple linear regression analysis showed that the multiple influencing factors of the quality of life among left‐behind children in Shandong and Sichuan provinces were age ,the guardian、left‐behind time、parents′care and study result .Conclusion The quality of life among left‐behind children in Shandong and Sichuan provinces was not high and was affected by many factors .In order to improve the quality of life of left‐behind children ,the guardians should pay more attention to care and communicate with their children in the future education and management of left‐behind chil‐dren ,especially the elder ,long time left behind or poor grades ones .
2.Clinicopathological Characteristics and Prognosis Analysis of 39 Patients with Pulmonary Sarcomatoid Carcinoma
CHEN CEN ; REN ZHANLIANG ; DONG YUJIE ; WANG YING ; GAO YUAN ; LI HONGXIA ; ZHANG TONGMEI
Chinese Journal of Lung Cancer 2024;27(7):514-522
Background and objective Pulmonary sarcomatoid carcinoma(PSC)is a rare subtype of non-small cell lung cancer(NSCLC),which is featured by low incidence,high malignancy rate,robust aggressive behavior and inferior prognosis.To date,there is no standardized treatment.The aim of this study is to better understand and accumulate more clini-cal experience of the disease by summarizing the clinicopathological features,diagnosis methods,therapeutic regimen and prognostic factors of PSC.Methods A total of 39 patients with PSC who diagnosed and received treatment in Beijing Chest Hospital from December 2013 to December 2023 were retrospectively recruited,and information including demographic char-acteristics,clinicopathological features,tumor-node-metastasis(TNM)stage,diagnosis method and therapeutic regimen were carefully collected.Meanwhile,follow-up was conducted.Kaplan-Meier method was used to analyze the prognostic factors of the disease.Results The PSC patients in this study ranged in age from 45 to 76 years old,including 35 males and 4 females.There were no specific clinical manifestations of PSC at initial diagnosis.Among the 39 patients,20 underwent surgical resec-tion and 19 received palliative chemoradiation or symptomatic supportive treatment.The 1-year and 5-year survival rates were 61.90%and 35.20%respectively.Univariate analysis indicated that family history of carcinoma,primary tumor site,TNM stage,lymph node metastasis,distant metastasis,whether or not received surgical resection,surgical method,treatment regimens,tumor tissue programmed cell death ligand 1(PD-L1)expression>1%and mesenchymal-epithelial transition factor(MET)pathway abnormalities were correlated with the overall survival(OS)of patients(P<0.05).In the subsequent multivariate analysis,lymph node metastasis emerged as the only independent prognosticator in predicting inferior OS(P=0.037).Conclu-sion PSC is rarely seen in clinical practice and commonly occurs in elder men with smoking history.Tumor tissue PD-L1 ex-pression>1%and MET abnormalities may predict inferior prognosis of PSC and lymph node metastasis was determined as the independent prognosticator of PSC.Surgical resection along with adjuvant medical treatment is the cornerstone for early and locally advanced patients,and the clinical utility of molecular targeting therapy and immunotherapy in PSC needs to be further investigated.