Objective To verify whether there is any difference between early-onset and late onset subtypes of psoriasis and the rationality of this classification. Methods A total of 1 632 patients with psoriasis vulgaris were included in this study. The distribution of age at onset was calculated. The disease severity at first visit and follow up, and the family history were assessed according to different ages at onset. The results were evaluated in the light of the data from a national psoriasis survey in 1984. Results There was only one peak regarding to the age at onset in psoriasis vulgaris, rather than two peaks according to our study, it was consistent with the results of the national large scale survey reported in 1984. It was found that the earlier the age at onset, the more frequently the patient had positive family history. There was some relationship between the disease severity and the age at onset, however, a clear cut age at onset by which the disease serverity could be determined was not identified in this study. Conclusion It is suggested that the early age at onset be related only to the increased possibility of family history. Its value in clinical management is not significant.

Objective In order to explore the relationship between the annual incidence rate of psoriasis and meteorological factors. Methods An investigation was carried out using single factor correlation analysis, multiple factor regression analysis and correlation analysis among meteorological factors. Results Single factor analysis revealed that the annual incidence of psoriasis showed a significant negative correlation with the mean annual air temperature, atmospheric pressure, relative humidity and whole year rainfall, but a positive correlation with the whole year sunshine time(P

Objective To characterize the natural history of psoriasis vulgaris.Methods A retrospective study was carried out.Totally,245 patients admitted to hospitals within three months after the first episode of psoriasis vulgaris were selected from 1136 patients with psoriasis vulgaris who had been followed up for more than 20 years.Changes in disease severity during the long-term follow-up were traced,and information on the shape and distribution of skin lesions,family history,use of anticancer drugs,vitamins and traditional Chinese medicines was collected and analyzed.SPSS13.0 software package was utilized to assess factors associated with the evolution of psoriasis vulgaris.Results The natural course of psoriasis vulgaris could be classified into six types:immediate healing,slow healing,intermittent relapse,frequent mild relapse,frequent moderate relapse,and frequent severe relapse.The immediate healing type and slow healing type amounted to 30％ of these patients,and the frequent severe relapse type to less than 10％.Statistical analysis revealed that the clinical severity of psoriasis was associated with the age of onset and family history,and was negatively correlated with the use of anticancer drugs.Conclusions The long-term follow-up study reveals the natural course of psoriasis vulgaris,which may be helpful in guiding the prediction of prognosis,prevention of recurrence and selection of treatment.

As a safe,cheap and effective diabetes drug,metformin has been used for many years.Diabetes increases the risk of liver cancer and affects its prognosis.In recent years,it is found that metformin reduces the pancreatic cancer risk in the treatment of diabetic patients,a large of experiments also prove that it has anti-cancer and synergistic anticancer effect.This paper focused on the effects of metformin on treatment of Ⅱ type diabetes,discussed the curative effect on liver cancer,suggested the molecular biology mechanism of inhibiting tumor,listed the latest experiment researches,analyzed the existed clinical data,proposed the further study of anticancer mechanism and clinical treatment.Metformin for a future role in prevention of hepatocellular carcinoma in patients with type Ⅱ diabetes are briefly summarized and future prospects,which in type Ⅱ diabetic patients with liver cancer in a prospective study of the effect of treatment.Mefformin for application in other cancer prevention also raises possibilities.