BACKGROUND: Mild hypothermia can protect cerebral cell from injury induced by ischemia, however, whether it can protect cerebral function after cerebral resuscitation or not?OBJECTIVE: To investigate the differences between neural functional outcome and living self-care ability of patients after 3-month cerebral resuscitation with mild hypothermia technique compared with normal temperature technique.DESIGN: Randomized control study.SETTING: Emergency Center of Gulou Hospital Affiliated to Medical College of Nanjing University.PARTICIPANTS: Totally 16 patients rescued with cardiopulmonary resuscitation were selected from Gulou Hospital of Nanjing between February and October 2002. All patients had systemic lesion and intoxication, and were treated with cardiopulmonary resuscitation because of heartbeat and respiratory arrest. There were 10 males and 6 females aged 27-57 years.According to the application of mild hypothermia or not, 16 cases were divided randomly into normal temperature group and mild hypothermia group with 8 in each group.METHODS: After cardio-pulmonary resuscitation, patients in mild hypothermia group were treated with medicine + caput ice cap + electronic ice blanket method to reduce the temperature. The temperature of brain was kept at 32 to 34 ℃ for 72 hours. Patients in normal temperature group were treated at the room temperature.MAIN OUTCOME MEASURES: ① Blood-oxygen saturation, blood pH value, intracranial pressure, mean arterial pressure and Glascow Coma Scale of patients were measured on the third and seventh day after resuscitation. ② After 3-month resuscitation, Glascow Coma Scale was followed:85-100 points as functional independency, 74-84 as moderate disability,10-50 as severe disability and ＜ 10 as vegetative slate; meanwhile, living self-care ability was measured with Bathel index of 10 items in total. Every item was scored from 0 to 15 points with 100 in total, and ＜ 60 was determined as unable self-care.RESULTS: Totally 16 patients entered the final analysis. ① On the third day, mean cerebral temperature and intracranial pressure in the mild hypothermia group were lower than those in the normal temperature group [(33.1±0.26)℃, (37.4±18)℃; 15.7 mm Hg, 19.1 mm Hg, P=0.027, 0.043]. The two groups were similar in the Score of blood-oxygen saturation, blood pH value, mean arterial pressure and Glascow Coma Scale (P ＞ 0.05). ② On the seventh day, Glascow Coma Scale in the mild hypothermia group was higher than that in the normal temperature group [(9.1±1.4), (11.2±1.6) points,P=0.032]. ③ After 3 months, Glascow Coma Scale and Barthel index in the mild hypothermia group were higher than those in the normal temperature group [(12.9±1.75), (9.9±1.9) points; (86±6), (52±12) points, P ＜ 0.05-0.01].CONCLUSION: Mild hypothermia can decrease intracranial pressure during the early cerebral resuscitation, is especially effective in the recovery of long-term neural function and activity of daily living, and has remarkable protecting effect on cerebral function.

Ech1 is the key enzyme of fatty acid β-oxidation metabolism,and mainly locates in peroxisome and mitochondria.Recent studies indicate that abnormal expression of Ech1 is related with liver carcinoma,stomach carcinoma and chronic lymphoid leukemia,but the mechanism is not very clear.Other members of Echfamily are also closely related to many diseases.

Diagnosis, Differential ; Humans ; Pneumoconiosis ; diagnosis

Chronic Disease ; Humans ; Male ; Middle Aged ; Mineral Oil ; adverse effects ; Occupational Exposure ; adverse effects ; Pigmentation Disorders ; chemically induced

Objective:To study the expression and significance of c-myc in pediatric lymph node swollen diseases.Methods:Expression of c-myc gene in swollen lymph node specimens of 84 children with lymph node swollen diseases were determined with SP immunohistochemistry technique.Results:(1)The positivity rates of the c-myc gene of lymphadenitis,reactive hyperplasia (RH) and lymphoma were 15.62%,40.48%,and 80.00%,respectively,and the difference was significant( ? 2=14.59, P

Objective:To establish a ?B2 crystallin gene knockout mice model.Methods: The gene-targeting vector was established by the technique of American inGenious Targeting Laboratory.PCR technique was used to identify the genotype of the model mice and expression of ?B2 crystallin protein was detected by Western blot.Results: Three genotypes were successfully(identified) and expression of ?B2 crystallin protein was not detected in gene knockout mice.Conclusion: The ?B2 crystallin gene knockout mice model has been successfully established.

The activity of interleukin-2 (IL-2) and expression of interleukin-2 receptor (IL-2 R) were measured in children with acute glomerulonephritis (AGN) in order to detemine the mechanism of the disease Our results showed that the activity of IL-2 in peripheral blood lymphocytes (PBL) of children with AGN was lower than that tof the control group (P

Objective To explore the real burden experience and feelings of the caregivers of patients with advanced pancreatic cancer in the process of care. Methods Totally 9 caregivers of patients with advanced pancreatic cancer were selected and investigated by in-depth interviews. Results Five major themes were found:Psychological burden,Physiological burden,Lack of knowledge, emotion, and economic support system,Challenges to personal life. Conclusions The caregivers of patients with advanced pancreatic bear the burden in Psychology, Physiology and personal life,and lack of emotional, economic and social support to different degrees at the same time. Doctors and nurses should pay attention to the caregivers, help them solve the difficulties, and provide scientific and effective nursing intervention.

OBJECTIVE:To discuss the role of clinical pharmacists in providing pharmaceutical care in respiratory department.METHODS:The clinical pharmaceutical care provided by clinical pharmacists in respiratory department was analyzed and summarized.RESULTS & CONCLUSION:The pharmaceutical care carried out in respiratory department can help reduce the incidence of medication errors.

OBJECTIVE:To discuss the position and role of hospital in pharmacovigilance.METHODS:The knowledge related to pharmacovigilance was introduced and the status quo and the responsibility assumed by hospital and its stuff in the pharmacovigilance work were analyzed.RESULTS & CONCLUSION:Hospital ought to be one of the main part in the pharmacovigilance,and through training to enhance the knowledge of the doctors,pharmacists and nurses about the pharmacovigilance,so that could build good system for the safety monitoring of drugs,and also could establish rules of pharmacovigilance to reduce ADR,improve rational use of medicine.