1.Clinical Efficacy of Salvia Miltiorrhiza Ligustrazine Combined with Alprostadil Injection in the Treatment of Diabetic Nephropathy
China Pharmacist 2016;19(2):303-305
Objective:To observe the curative effect and safety of salvia miltiorrhiza ligustrazine combined with alprostadil injec-tion in the treatment of diabetic nephropathy. Methods: Totally 84 patients with diabetic nephropathy admitted in our hospital from January 2012 to December 2013 were randomly divided into the observation group and the control group with 42 cases in each. Alpros-tadil injection was applied in the control group, and salvia miltiorrhiza ligustrazine combined with alprostadil injection was used in the observation group. The clinical efficacy of the two groups was compared. Results:The total effective rate was 95. 2% in the observa-tion group, which was significantly higher than that (83. 3%) in the control group (P<0. 05). BUN, Scr and urine former protein levels after the treatment were significantly lower than those before the treatment (P<0. 05), and the renal function in the observation group was significantly better than that in the control group (P<0. 05). Conclusion:Salvia miltiorrhiza ligustrazine combined with al-prostadil injection in the treatment of kidney disease is effective to promote the discovery of renal function, which is worthy of promoted application in clinical practice.
2.Risk factors for pancreatic fistula after distal pancreatectomy
Gaoqing WANG ; Caide LU ; Weiming YU ; Zesheng WANG ; Yongfei HUA ; Tao PENG
Chinese Journal of General Surgery 2015;30(5):344-347
Objective To find the potential risk factors for pancreatic fistula after distal pancreatectomy.Methods Clinical data of 125 cases of consecutive distal pancreatectomy in Ningbo Lihuili Hospital from January 2006 to June 2013 were retrospectively analyzed.Results In all the 125 patients with distal pancreatectomy,pancreatic fistula was the most common surgical complication (43/125,34.4%),including 27 cases of grade A fistula,16 cases of grade B pancreatic fistula.Multivariate analysis showed that the texture of the pancreas and main pancreatic duct ligation were the independent risk factors for pancreatic fistula (all P < 0.05).Conclusions Pancreatic fistula was the most common surgical complication of distal pancreatectomy.The texture of the pancreas and main pancreatic duct ligation effect the occurrence of postoperative pancreatic fistula.
3.Combined prognostic utility of NT-proBNP and hs-CTNI in NSTE-ACS risk stratification and its therapy
Ya LI ; Tao GENG ; Yongxin LIU ; Bingxun WANG ; Shipeng DAI ; Jiangang ZHANG ; Wanzhong PENG ; Zesheng XU
Chongqing Medicine 2013;(28):3377-3378,3381
Objective To research the combined prognostic utility of NT-proBNP and hs-CTNI in NSTE-ACS risk stratification and early intervention therapy .Methods A total of 245 NSTE-ACS patients were divided to 4 groups(Aa ,Ab ,Ba ,Bb groups) ac-cording to immediate admission NT-proBNP and hs-CTNI .Patients were accepted percutaneous coronary intervention (PCI) ,coro-nary artery bypass grafting and conservative treatment were taken 6 months follow-up .Results The heart failure incidence of Aa group was significantly higher than Ba group(P<0 .05) .6 patients happened left main lesion or multivessel lesion in Aa group were obviously higher than other groups .The incidence of Bb group accepted PCI was obviously higher than Aa group (P<0 .05) .Bb group patients were accepted PCI earlier than other groups ,there was no significance(P>0 .05) .In 6 months follow-up ,5 patients died and 10 patients accepted revascularization again because of severe angina and AMI .Conclusion In NSTE-ACS patient ,NT-proBNP and hs-CTNI elevation was closely related with severe coronary lesions and worse prediction ,which could undergo early in-tervention therapy .
4.A case of guidewire-induced distal coronary perforation treated with microcatheter delivery of intracoronary thrombin.
Shipeng DAI ; Zesheng XU ; Jiangang ZHANG ; Bingxun WANG ; Yongxing LIU ; Ya LI ; Tao GENG ; Yonggang YUAN ; Zengcai MA ; Zhiyuan SONG ; Wanzhong PENG
Chinese Journal of Cardiology 2015;43(1):76-77
5.The correlation between the clinical characteristics of HCC patients with different phenotype circulating tumor cells in the peripheral blood
Lei LUO ; Bangjian PENG ; Zesheng JIANG ; Guolin HE ; Yuan CHENG ; Yi GAO ; Mingxin PAN
Chinese Journal of Hepatobiliary Surgery 2018;24(1):13-17
Objective To study the correlation between the clinical characteristics of HCC patients with different phenotype circulating tumor cells in the peripheral blood.Methods 77 patients with HCC and 21 patients with benign liver diseases treated at Zhujiang Hospital of Southern Medical University from April 2015 to December 2016 were retrospectively studied.The CanPatrolTM System was adoptedto detect epithelial-mesenchymal phenotype CTCs in the peripheral blood.This study aimed to clarify whether the epithelial-mesenchymal phenotype CTCs were specifically originated from the tumorand to investigate the correlation between CTCs and the clinical features of the patients.Results Using epithelial and mesenchymal markers,the CTCs were divided into three subtypes:epithelial,mesenchymal and mixed CTCs.No epithelial-mesenchymal phenotype CTCs were detected in patients with benign liver diseases.The positivity rates of epithelial,mixed and mesenchymal CTCs in the peripheral blood of 77 patients with HCC were 37.7% (29/77),74.0% (57/77) and 50.6% (39/77),respectively.The positivity rates of epithelial-mesenchymal phenotype CTCs in patients with HCC were significantly higher than the group of patients with benign liver diseases (P < 0.05).The positivity rates of epithelial CTCs were significantly correlated with AFP,number of tumor and portal vein tumor thrombus (P < 0.05).The positivity rates of mixed CTCs were significantly correlated with portal vein tumor thrombus,tumor differentiation and BCLC stage (P < 0.05).The positivity rates of mesenchymal CTCs were significantly correlated with tumor size,portal vein tumor thrombus,tumor differentiation and BCLC stage (P < 0.05).Conclusions The positivity rates of epithelial,mixed and mesenchymal CTCs were closely related to different aspects of clinical characteristics of patients with HCC.These CTCs may serve as indicatorsto evaluatethe progress of HCC.
6.Research progress of the mechanism for PD-1 molecule regulating pulmonary fibrosis and its research prospects in silicosis
Zesheng CHEN ; Yiming WU ; Ting ZHOU ; Zhe PENG ; Tingming SHI ; Xiuqing CUI
Journal of Public Health and Preventive Medicine 2022;33(4):118-123
Programmed death factor-1 (PD-1) is a promising target molecule for clinical tumor immunotherapy in recent years. Recent studies suggest that PD-1 and related signaling pathways (PI3K/AKT, JAK/STAT3, p38MAPK, ERK, etc.) played a key regulatory role in the process of pulmonary fibrosis. Silicosis is a systemic disease caused by inhalation of free silicon dioxide dust, which is mainly characterized by extensive pulmonary nodular fibrosis and seriously endangers the health of patients. Dissecting the role of PD-1 in the pathogenesis of silicosis may be of great significance in the mechanism research and clinical diagnosis and treatment of silicosis. This paper reviews the regulation of PD-1 molecule on related signaling pathways and its role in pulmonary fibrosis, and looks forward to the potential application of these mechanistic studies in silicosis research.