1.Preparation and Quality Control of Compound Lincomycin Nasal Drops for Children
Chenmei MAO ; Yun JIANG ; Zengyan ZHU ; Xunwu DOU
China Pharmacy 2007;0(31):-
OBJECTIVE: To prepare compound lincomycin nasal drops for children and establish a quality control method for this preparation. METHODS: Compound lincomycin nasal drops for children were prepared using lincomycin hydrochloride as main component with its content determined by polarimetry. The content and stability of the preparation within 12mon under room temperature were investigated. Meanwhile irritating test of rabbits' nasal mucosa was conducted. RESULTS: The prepared eye drops were limpid colorless liquid and it met the related standards stated in China Pharmacopeia(2005 edition) in identification as well as tests etc. Lincomycin hydrochloride showed a good linear relation in the range of 3.2~20.0mg?mL-1(r=0.999 9), with average recovery at 100.6%(RSD=0.69%). This preparation showed a little irritation on nasal mucosa, and it was stable within 12mon under room temperature. CONCLUSIONS: This preparation is simple and feasible in preparation technology and controllable in quality.
2.Difference analysis of ADE signal for irinotecan in adults and children
Fang LI ; Xiaohuan DU ; Xiang SHANG ; Wenjuan WANG ; Mi ZHOU ; Zengyan ZHU
China Pharmacy 2024;35(11):1369-1373
OBJECTIVE To mine and analyze the post-marketing adverse drug event (ADE) signals of irinotecan in adults and children populations, and to provide a reference for clinical safe medication. METHODS ADE reports of irinotecan from the first quarter of 2004 to the first quarter of 2023 in the US FDA adverse event reporting system database were extracted and the risk signals of irinotecan were detected through the reporting odds ratio and proportional reporting ratio. Statistical analysis was performed for ADE reports and signals of patients aged<18 years (children) and ≥18 years (adults). RESULTS A total of 8 013 ADE reports with irinotecan as the primary suspect drug were identified, including 7 656 and 357 ADE reports in adults and children, respectively. A total of 518 and 75 ADE signals were detected in the adults and children, and the mainly involved systems and organs including gastrointestinal disorders, blood and lymphatic system disorders, systemic disorders and various reactions at the administration site, etc. Most of the top 20 ADE signals in terms of frequency were documented in the drug instructions of irinotecan. New ADE signals in adults included peripheral neuropathy, oral mucosal inflammation, pulmonary embolism, epidermal nevus syndrome and reproductive toxicity, while hypertension, progressive neoplasms, tumor lysis syndromes, and embolism were new ADE signals in children. CONCLUSIONS The above new suspected high-risk signals not mentioned in the instructions should raise a high level of alertness in clinical practice of irinotecan.
3.Difference analysis of ADE signal for irinotecan in adults and children
Fang LI ; Xiaohuan DU ; Xiang SHANG ; Wenjuan WANG ; Mi ZHOU ; Zengyan ZHU
China Pharmacy 2024;35(11):1369-1373
OBJECTIVE To mine and analyze the post-marketing adverse drug event (ADE) signals of irinotecan in adults and children populations, and to provide a reference for clinical safe medication. METHODS ADE reports of irinotecan from the first quarter of 2004 to the first quarter of 2023 in the US FDA adverse event reporting system database were extracted and the risk signals of irinotecan were detected through the reporting odds ratio and proportional reporting ratio. Statistical analysis was performed for ADE reports and signals of patients aged<18 years (children) and ≥18 years (adults). RESULTS A total of 8 013 ADE reports with irinotecan as the primary suspect drug were identified, including 7 656 and 357 ADE reports in adults and children, respectively. A total of 518 and 75 ADE signals were detected in the adults and children, and the mainly involved systems and organs including gastrointestinal disorders, blood and lymphatic system disorders, systemic disorders and various reactions at the administration site, etc. Most of the top 20 ADE signals in terms of frequency were documented in the drug instructions of irinotecan. New ADE signals in adults included peripheral neuropathy, oral mucosal inflammation, pulmonary embolism, epidermal nevus syndrome and reproductive toxicity, while hypertension, progressive neoplasms, tumor lysis syndromes, and embolism were new ADE signals in children. CONCLUSIONS The above new suspected high-risk signals not mentioned in the instructions should raise a high level of alertness in clinical practice of irinotecan.
4.Progress in the spectral library based protein identification strategy.
Derui YU ; Jie MA ; Zengyan XIE ; Mingze BAI ; Yunping ZHU ; Kunxian SHU
Chinese Journal of Biotechnology 2018;34(4):525-536
Exponential growth of the mass spectrometry (MS) data is exhibited when the mass spectrometry-based proteomics has been developing rapidly. It is a great challenge to develop some quick, accurate and repeatable methods to identify peptides and proteins. Nowadays, the spectral library searching has become a mature strategy for tandem mass spectra based proteins identification in proteomics, which searches the experiment spectra against a collection of confidently identified MS/MS spectra that have been observed previously, and fully utilizes the abundance in the spectrum, peaks from non-canonical fragment ions, and other features. This review provides an overview of the implement of spectral library search strategy, and two key steps, spectral library construction and spectral library searching comprehensively, and discusses the progress and challenge of the library search strategy.
5.Recommendations for prescription review of antipyretic-analgesics in symptomatic treatment of children with fever
Xiaohui LIU ; Xing JI ; Lihua HU ; Yuntao JIA ; Huajun SUN ; Qinghong LU ; Shengnan ZHANG ; Ruiling ZHAO ; Shunguo ZHANG ; Yanyan SUN ; Meixing YAN ; Lina HAO ; Heping CAI ; Jing XU ; Zengyan ZHU ; Hua XU ; Jing MIAO ; Xiaotong LU ; Zebin CHEN ; Hua CHENG ; Yunzhu LIN ; Ruijie CHEN ; Xin ZHAO ; Zhenguo LIU ; Junli ZHANG ; Yuwu JIANG ; Chaomin WAN ; Gen LU ; Hengmiao GAO ; Ju YIN ; Kunling SHEN ; Baoping XU ; Xiaoling WANG
Chinese Journal of Applied Clinical Pediatrics 2022;37(9):653-659
Antipyretic-analgesics are currently one of the most prescribed drugs in children.The clinical application of antipyretic-analgesics for children in our country still have irrational phenomenon, which affects the therapeutic effect and even poses hidden dangers to the safety of children.In this paper, suggestions were put forward from the indications, dosage form/route, dosage suitability, pathophysiological characteristics of children with individual differences and drug interactions in the symptomatic treatment of febrile children, so as to provide reference for the general pharmacists when conducting prescription review.