OBJECTIVE： To survey an evaluate the current situation and trend of the use of digestive system drugs.METHODS： To make a survey of the use of the above-mentioned drugs in 51 hospitals of four provinces in southwest China during the period 1999～2000 in respect to the sum of money of sales， main kinds， DDDs etc.and to analyse the clinical application of these drugs.RESULTS： As the sum of money for sales of the digestive system drugs， it was increased 42.08％ in 2000 compared with that in 1999.As the DDDs of the digestive system drugs， it is increased 8.85％ in 2000 compared with that in 1999.The average cost of DDD was 2.76 yuan in 2000 and 2.60 yuan in 1999.CONCLUSION： The digestive system drugs is an important kind of drug which has prospects of fast increase.