Objective: To study therapeutic action of Chinese drugs on fibrosis of liver due to chronic hepatitis. Methods: The treatment group (n=40) were treated by Chinese drugs for removing pathogenic heat from the blood and toxic material from the body, and nourishing the kidney and liver, and the control group(n=30) were treated by Aotaile Infusing Powder and Dahuang Zhechong Bolus for 6 months. Changes of indexes of fibrosis of liver were investigated. Results: After treatment, serum hyaluronic acid (HA), laminin(LM), type Ⅳ collagen peptide, and type Ⅲ collagen peptide decreased in the treatment group as compared with those in the control group (P