Object To study the regularity of changes on quality and yield of Coptis chinensis Franch. with its different age and month at different altitude. Methods Weighting by stoving and colorimetric analysis were used to determine the content of berberine and the weight of C. chinensis in different age and month at different altitude. Results The yield and quality of C. chinensis grown in low altitude region are better than that in high altitude region; the wight of C. chinensis in five years old is the biggest. The content of berberine of C. chinensis in six years old is the highest. And the weight and berberine content of C. chinensis in July is the highest in one year. Conclusion Results of the study may provide references for C. chinensis production and the selection of the best harvest period.