OBJECTIVE:To discuss the drug resistance situation and influential factors of sputum culture positive tuberculosis patients in a specialized subject hospital. METHODS:The information of sputum culture positive tuberculosis inpatients were col-lected from Heze infectious disease hospital during Jan. 1st 2014 to Apr. 30th 2015;the results of drug sensitive test were analyzed retrospectively by using absolute concentration method. RESULTS:Among 259 patients,137 cases were drug-resistant(52.90%), among including 69(26.64%) mono-drug resistant cases,52(20.08%) poly-drug resistant cases,15(5.79%)multi-drug resistant cases and 1(0.39%)extensively drug resistant case;streptomycin (31.66%) and amikacin (15.44%) were drugs with the highest drug-resistant rate;there was no statistical significance in resistant rate between different genders and ages(P>0.05),the rate of drug resistance in first-treatment patients was 47.21%,and that of the re-treatment patients was 70.97%,the difference was statisti-cal significant(P<0.05). In addition to ethambutol and kanamycin,other all had mono-drug resistance,there were 27 combinations of poly-drug resistance and 9 combinations of multi-drug resistance. Logistic regression analysis showed that treatment history was a risk factor for drug-resistance,the risk of re-treatment patient was 2.734 times of first-treatment patients. CONCLUSIONS:Sputum culture positive tuberculosis inpatients patients have high drug resistance and complex spectrum in the hospital;we should pay great attention to the risk of drug resistance in senile patients and re-treatment patients,and rational use of streptomycin,amikacin,isoni-azid and capreomycin.

OBJECTIVE:To investigate the protective effect of Guishu blood-activating capsule on cerebral ischemical reperfusion injury of rats.METHODS:The cerebral embolism model rats were established,the rats were randomly divided into model group,nimodipine positive control group,Guishu blood-activating capsule(high,medium and low dosage groups,re?spectively)group and with another sham operation group established.Each group was administered intragastrically with water or the corresponding drugs,the cortexes and hippocampus tissues of the rats were divided into the injured side and the control side,the contents of aspartate(Asp),glutamate(Glu),malonaldehyde(MDA),lactate dehydrogenase(LD),the tumor necrosis factor?(TNF-?)and the activity of glutathione peroxidase(GSH-Px)were determined,the cerebral infarct size was determined by red tetrazoline staining method and the cerebral water content was determined by oven dry process.RE?SULTS:Compared with the model group,in one or several sub-groups of Guishu group,no marked change was noted in the content of Asp while that of the Glu in the injured side of the hippocampus tissues decreased significantly(P