Objective To discuss the influence of establishment of special nursing clinic on medical compliance behavior of diabetic patients. Methods We randomly selected outpatients from the endocrine department and special nursing clinic as the control group and the observation group with 100 cases in each group respectively. The condition of medical compliance behavior and blood glucose control was observed and compared in the two groups. Results The patients visiting special nursing clinic were better in medical compliance behavior and blood glucose control. Conclusions Establishment of special nursing clinic for diabetic outpatients can improve the medical compliance behavior, satisfying the requirement for disease knowledge, enhance the shaping of healthy behavior and facilitate the control of disease progress.