1.Cerebral magnetic resonance imaging characteristics of eclampsia:an analysis of 15 cases
En WANG ; Wei-Hai XU ; Qin HUANG ; Jing-Rong DING ; Xiao-Ping JIN ; Ze-Ying CHAI ; Ling SUN ; Sheng XU ;
Chinese Journal of Neurology 2000;0(05):-
Objective To investigate cerebral MRI characteristics of patients with eclampsia. Methods A retrospective study was conducted on 15 cases of eclampsia and items reviewed cover all data concerning clinical features,cerebral MRI findings and results of follow-up survey.Results All of these patients had clinical symptoms of.blurred vision,headache,seizure,hypertension,proteinuria and edema of lower extremity.As for the characteristics of imaging,13 cases had only abnormal symmetric signals in parieto-occipital lobes,frontal lobe and basal ganglia were involved in 2 cases,and temporal lobe was involved in 1 case.The signals of lesions in DWI were isointense or hypointense,however they were hyperintense in ADC map.Two cases had hyperintense signals in DWI.All the patients recovered well,and all brain lesions disappeared during follow up.Conclusion The most important imaging of eclampsia is vasogenic edema with a good prognosis.
2.Expression of inhibitor of differentiation -1 in cervical cancer tissues and its correlation with Ki-67
Li-Juan MA ; Jin-Cai HE ; Ze-Ying CHAI
The Chinese Journal of Clinical Pharmacology 2015;(8):627-630
Objective To investigate the expression of inhibitor of differentiafion-1 ( Id-1) in tissues of cervical cancer , cervical intrae-pithelial neoplasma ( CIN) and normal cervical tissue , and its correlation with Ki -67.Methods The expression of Id -1 were examined in cervical cancer (60 cases), CIN (37 cases of CIN I and 23 cases of CINⅡ-Ⅲ) , and normal cervical tissues by immunohistochemical SP method.The expression of Ki -67 in 60 cervical cancer tissue were detected and the correlation between the expression of Id-1 and Ki-67 protein in cervical carcinoma were analyzed .Results The positive rates of Id -1 were 6.67%, 10.81%, 56.52% and 76.67% in normal tissue, CIN I, CIN II -III and cervical cancer tissues , respectively (P<0.05), and 10.00%, 21.62%, 65.21%, 80.00% in terms of the positive rate of Ki-67.The expressions of Id -1 and Ki-67 were positively correlated with the degree of cancer differentiation , vascular invasion, lymph node metastasis, and International Federation of Gynecology and Obstetrics (FIGO) stage (P<0.05).Conclusion Up-regulation of Id-1 expression may have a certain relationship with the occurrence and development of cervical cancer , and the expression of Id -1 and Ki-67 has synergistic effect on the occurrence and development of cervical cancer .