Objective To explore the relationship between the expression of XRCC1 and glioma. Methods Total of 26 samples of glioma were divided into 4 groups:gradeⅠ,gradeⅡ,gradeⅢand gradeⅣ. The expression of XRCC1 in 26 Gliomas tissues were examined using SP immunohistochemical staining.Results The positive staining of XRCC1 protein was localized in nucleus of tumor cells in Glioma. There was no correlation among them. The difference of XRCC1 expression among gradeⅠ~Ⅳ was not significant ( >0.05) .Conclusion The difference of XRCC1 expression among gradeⅠ~Ⅳ was not significant. The expression of XRCC1 was closely correlated with the effect of radiotherapy.

Background and objective Pulmonary ifbrosis is a common pathological phenomenon in lung cancer patients atfer chemotherapy or radiotherapy. It is also a key hindrance to the transport of drugs to lung tissue. Peptide trans-porters have become a target of the rational design of peptides and peptide drugs. hTe aim of this study is to investigates the expression of peptide transporter 2 (PEPT2) mRNA in the lungs of rats with bleomycin (BLM)-induced pulmonary ifbrosis. Methods Fitfy healthy adult Sprague-Dawley rats were randomly divided into ifve groups. One group was untreated (control), the second group was injected with normal saline solution (NS), and the three remaining groups were treated with a single dose of bleomycin to induce pulmonary ifbrosis (BLM). Rats from the NS group were killed by exsanguination on day 14. Rats from the BLM group were killed by exsanguination on days 7, 14, and 28. hTe lung samples were observed under light microscopy and the hydroxyproline concentration was determined. hTe expression levels of PEPT2 mRNA were measured by RT-PCR. Results hTe morphological study showed that collagenous ifber proliferated in the lungs of rats injected with BLM, indicating pulmonary ifbrosis. hTis proliferation was apparent at 14 d post-injection and especially at 28 d post-injection. Hydroxyproline levels increased seven days post-injection compared with the control group and NS group, but there was no signiifcant statisti-cal difference (P>0.05). Hydroxyproline levels signiifcantly increased (P<0.05) 14 d and 28 d post-infection. hTe change in the lung tissue pathology coincided with the change in hydroxyproline levels. hTere were no signiifcant changes of pulmonary PEPT2 mRNA expression levels among the different groups (P>0.05). Conclusion PEPT2 is a potential peptide drug target in the treatment of pulmonary ifbrosis, although there were no signiifcant changes of PEPT2 mRNA expression in the lungs of rats with bleomycin-induced pulmonary ifbrosis.