Objective To evaluate the effect of endoscopic ultrasonography (EUS) in diagnosing pancreatic carcinoma. Methods To compare the results of EUS with those of intraductal ultrasonography (IDUS), abdominal ultrasonography ,CT/MRI and ERCP in 116 cases of pancreatic carcinoma . Results The sensitivity and accuracy of EUS including IDUS were the highest. The diagnostic accuracies of EUS,IDUS,CT,MRI,ERCP and sonography were 98. 2% ,100% ,85. 3%,87. 0% ,80. 6% and 73. 2% respectively. Conclusion EUS had significant value in the diagnosis of pancreatic carcinoma.