Human ; Male ; Adult ; Young Adult ; Hemophilia A ; Neoplasms ; Thigh ; Lower Extremity

Introduction: Syphilis is a chronic systemic infection caused by Treponema pallidum sub-species pallidum. Syphilis, by itself, already has a varied clinical presentation depending on the stage, earning its moniker as “the great imitator”. In a patient without HIV infection, untreated syphilis presents as a chronic infection with primary, secondary, latent, and tertiary stages. With the emergence of the AIDS pandemic, HIV co infection may significantly alter the clinical presentation of syphilis. This is a case of a patient with neurosyphilis with overlapping primary and secondary syphilis. Case Presentation: This is a case of a 34-year-old Filipino male who came in due to blurring of vision. The patient’s illness started six months prior to admission, when he noted the appearance of a painless, non-pruritic, solitary ulcer with erosions on his penis. A month after, he started to have progressive blurring of vision. In the interim, erythematous, scaly plaques appeared on the dorsal aspect of both hands and feet, and on the tip of the nose, with associated thinning of hair on the scalp and eyebrows. The skin and penile lesions eventually increased in size and number. The examination of the pupils showed a 6 mm right pupil, non-reactive to light, and a 2 mm left pupil which was minimally reactive to light and constricts upon accommodation. The diagnosis of syphilis was confirmed by a reactive serum Rapid Plasma Reagin at 1:64 dilution, and a reactive serum Treponemal Enzyme Immunoassay. HIV screening was also reactive, with a CD4+ cell count of 15 cells/μL. Ophthalmologic findings were consistent with panuveitis. Skin punch biopsy revealed lichenoid and interstitial dermatitis with which syphilis was highly considered. Cranial CT imaging showed mild cerebral atrophy. Lumbar tap revealed a colorless, clear cerebrospinal fluid, with lymphocytic pleocytosis, normal protein, decreased glucose, and a reactive CSF RPR. The patient was given intravenous penicillin G 3 million units every 4 hours for 14 days, together with ophthalmic medications (prednisolone, levofloxacin, and atropine ophthalmic drops). He was also started on antiretroviral therapy. Prior to discharge, the patient was noted to have improved vision, skin lesions were significantly improved, and he was advised for close monitoring as outpatient. Conclusion Through this case, it was elaborated that with HIV co-infection, syphilis may present atypically—with multiple, persistent, primary lesions; with overlapping of the stages, and increased frequency of neurosyphilis presenting early into the infection.
Syphilis ; Neurosyphilis ; HIV