3.Diagnostic challenge of Burkitt’s lymphoma at early age
Nor Fauziah Handar ; Faizah Mohd Zaki ; Loh C-Khai
The Medical Journal of Malaysia 2017;72(5):324-326
A four-year-old Ibanese boy presented with subacute
abdominal distension for two months duration. Ultrasound
and computed tomography (CT) scan showed solid liver
masses as well as bowel and intraperitoneal lesions. Initial
diagnosis of intraperitoneal inflammatory process as in
tuberculosis with non-liquefied liver abscess with
differential diagnosis of neoplastic process was made. Liver
biopsy and peritoneal fluid analysis revealed Burkitt’s
lymphoma (BL). We aim to highlight the diagnostic
challenge of BL in this young age group emphasizing on the
ultrasound and CT features of intraabdominal BL. We would
also want to stress the importance of early diagnosis of BL
as it is known to be the most aggressive tumour within 24
hours yet to have good survival if early diagnosis was made.
Lymphoma
;
Child
4.Informed Consent in Clinical Trials with Reference to Information Disclosure to Patient-Subjects
Yuhanif Yusof ; Anisah Che Ngah ; Zaki Morad Mohamad Zaher
International Journal of Public Health Research 2014;4(1):384-390
The aim of this study was to examine the aspect of information disclosure by doctor-investigator during the process of obtaining informed consent in clinical trials. This research employed a mixed-method data collection that is library research and interview. A qualitative methodology and analysis were used in an open-ended, face-to-face interviews with 17 patient-subjects. The interview questions were based on information that needed to be disclosed to patient-subjects during the process of obtaining informed consent. Each interview took place in Kajang Hospital and National Heart Institute and lasted 25-30 minutes. Interviews were conducted in Bahasa Melayu and English. The interviews were tape-recorded, and the main points from the interviews were jotted down to ensure that all information was adequately gathered. Interviewed occurred in Kajang Hospital and National Heart Institute. The participants were patients who had been referred to the Kajang Hospital and National Heart Institute. They were recruited (8 from Kajang Hospital and 9 from National Heart Institute) by their own doctors to participate in a study to evaluate the safety and effectivenes of the investigational stent after been diagnosed with coronary artery disease and also in a study to investigate drug for antidepressant. respectively. The study revealed that doctor-investigators fail to disclose full information to patient-subjects. Instead, doctor-investigators only disclosed information which they thought were necessary for the patient-subjects to know. The study also showed that there were doctor-investigators who did not disclose information at all to the patient-subjects. This study implies that the aspect of information disclosure in the process of obtaining informed consent in clinical trials is rather poor and did not fulfill the criterion of good medical practice. A random monitoring task to be conducted by the research ethics commitees during the informed consent process is suggested.
5.Factors Influencing Pap Smear Practice Among Primary School Teachers In Diyala City, Iraq
Oras Zaki Saadoon ; Rahmah Mohd Amin ; Saad Ahmed Ali Jadoo
Malaysian Journal of Public Health Medicine 2014;14(1):19-28
Cervical cancer is the seventh most common cancer among women in Iraq. This study aimed to assess the factors influencing Pap smear practice among married primary school teachers in Diyala City, Iraq. A total of 222 teachers (aged 20 years to 63 years) residing in Diyala City were enrolled in a cross sectional study from 1st August till 30th September 2012. The sampling method was a self-administered survey using a multistage sampling technique. The prevalence of Pap smear practice was very low (12.6%). Relatives and friends were the main source of information about the Pap smear test for more than one third (41.9%) of the respondents. However, the medical doctor’s advice was the most important reason for undergoing a Pap smear test in more than two third (60.7%) of respondents. Only 32.4% of the teachers have good knowledge about cervical cancer and Pap smear test, but 76.1% of them showed a positive attitude toward learning about cervical cancer and Pap smear. Based on multiple logistic regression analysis results only the husband’s encouragement (p= 0.003, prevalence odds ratio [POR] = 0.256, 95%CI 0.10-0.63) was significantly associated with Pap smear practice. A more effective educational program is needed to educate Iraqi women about cervical cancer and screening tests, including Pap smear.
Papanicolaou Test
6.Noise exposure Among Maintenance Crews Of C130H Air-Craft Lead To The Hearing Impairment
Aziizur Rahman Abdul Aziz ; Saardin Abd Aziz ; Mohamad Zaki Hassan
Malaysian Journal of Public Health Medicine 2017;Special Volume(1):89-94
The objective
s
of the research are
t
o
identify
the
noise sources
and
noise level
exposure
inside C130H aircraft
’s
hangar
;
to
produce nois
e mapp
ing
;
to identify hearing status of C
130H aircraft
maintenance crews
(MC)
;
and suggesting the noise
control measure that can be applied.
A field
survey on noise level by using
a
digital s
ound
level m
eter
and producin
g noise
mapping
.
A
h
earing test
ing
among
63
MC
was
carried out in
Institute of Aviation Me
dicine
,
Royal Malaysian Air
Force (
RMAF
)
.
Reviewing the literature and
a
nalyzing some control measure
s
to be taken.
Hearing test result
shown 41.2% of the MC
are having hearing impairment. The highest
noise level
at the central of the hanga
r is 92.2 dB
A
(
day
-
time) and 94.2 dBA (night
-
time) when there is a C130H aircraft starting its engine
at
50 meter
s
from the centr
al of the
hanga
r, 95.3 dBA (day
-
time) and 97.3 dBA (night
-
time) when there is a C130H a
ircraft Engine Ground Run
at 150 meter
s
fr
om the centra
l
of the hanga
r. Besides,
Auxiliary Power Unit
is producing the highest nois
e level which is 125.7 dBA
(day
-
time) and 127.7 dBA (night
-
time)
.
The application of Personal Protective Equipment
(PPE)
is the very likely control
measure to be taken while engin
eering control is ve
ry costly but
can be considered.
Since
noise
is
recognized as
a
hazard,
hearing protection as
PPE
will not be the ultimate solution as a control measure. Hence, the Engineering Control must be
identified and studied to be implemented
as an ultimate solution
to
control the noise hazard in long term duration.
7.Developmental Dysplasia of Hip Screening Using Ortolani and Barlow Testing on Breech Delivered Neonates
AR Sulaiman ; Zakaria Yusof ; I Munajat ; NAA Lee ; Nik Zaki
Malaysian Orthopaedic Journal 2011;5(3):13-16
Introduction: We conducted this study to compare the
specificity and sensitivity of the Ortolani and Barlow tests performed by dedicated examiners, and to ascertain the incidence of developmental dysplasia of the hip (DDH) in breech babies. Methods: A dedicated examiner underwent
specific training and testing by a paediatric orthopaedic
surgeon. Routine examiners were medical officers who had
basic training in medical school and were briefly trained by their superiors. The dedicated examiner examined 170
babies. Thirty babies including 5 babies with positive tests (according to the dedicated examiner) were examined by a blinded routine examiner. Results of Ortolani and Barlow tests on 30 babies were compared with ultrasound
examination by blinded radiologist. Results: Five babies had positive Ortolani and Barlow tests. The routine examiner did not detect positive Ortolani and Barlow tests. Conclusion: The incidence of positive Ortolani and Barlow tests among breech babies was 2.8%. Result of Ortolani and Barlow tests by dedicated hip screener were better than results performed by routine examiner.
8.Identification of masses in digital mammogram using gray level co-occurrence matrices
A Mohd. Khuzi ; R Besar ; WMD Wan Zaki ; NN Ahmad
Biomedical Imaging and Intervention Journal 2009;5(3):1-13
Digital mammogram has become the most effective technique for early breast cancer detection modality. Digital
mammogram takes an electronic image of the breast and stores it directly in a computer. The aim of this study is to develop an automated system for assisting the analysis of digital mammograms. Computer image processing techniques
will be applied to enhance images and this is followed by segmentation of the region of interest (ROI). Subsequently, the textural features will be extracted from the ROI. The texture features will be used to classify the ROIs as either masses or non-masses. In this study normal breast images and breast image with masses used as the standard input to the proposed system are taken from Mammographic Image Analysis Society (MIAS) digital mammogram database. In MIAS database, masses are grouped into either spiculated, circumscribed or ill-defined. Additional information includes
location of masses centres and radius of masses. The extraction of the textural features of ROIs is done by using gray level co-occurrence matrices (GLCM) which is constructed at four different directions for each ROI. The results show that the GLCM at 0º, 45º, 90º and 135º with a block size of 8X8 give significant texture information to identify between masses and non-masses tissues. Analysis of GLCM properties i.e. contrast, energy and homogeneity resulted in receiver operating characteristics (ROC) curve area of Az = 0.84 for Otsu’s method, 0.82 for thresholding method and Az = 0.7 for K-mean clustering. ROC curve area of 0.8-0.9 is rated as good results. The authors’ proposed method contains no complicated algorithm. The detection is based on a decision tree with five criterions to be analysed. This simplicity leads to less computational time. Thus, this approach is suitable for automated real-time breast cancer diagnosis system
9.Noise Exposure Among Maintenance Crews Of C130h Aircraft Lead To The Hearing Impairment
Aziizur Rahman Abdul Aziz ; Saardin Abd Aziz ; Mohamad Zaki Hassan
Malaysian Journal of Public Health Medicine 2017;2017(Special Volume (1)):89-94
The objectives of the research are to identify the noise sources and noise level exposure inside C130H aircraft’s hangar; to produce noise mapping; to identify hearing status of C130H aircraft maintenance crews (MC); and suggesting the noise control measure that can be applied. A field survey on noise level by using a digital sound level meter and producing noise mapping. A hearing testing among 63 MC was carried out in Institute of Aviation Medicine, Royal Malaysian Air Force (RMAF). Reviewing the literature and analyzing some control measures to be taken. Hearing test result shown 41.2% of the MC are having hearing impairment. The highest noise level at the central of the hangar is 92.2 dBA (day-time) and 94.2 dBA (night-time) when there is a C130H aircraft starting its engine at 50 meters from the central of the hangar, 95.3 dBA (day-time) and 97.3 dBA (night-time) when there is a C130H aircraft Engine Ground Run at 150 meters from the central of the hangar. Besides, Auxiliary Power Unit is producing the highest noise level which is 125.7 dBA (day-time) and 127.7 dBA (night-time). The application of Personal Protective Equipment (PPE) is the very likely control measure to be taken while engineering control is very costly but can be considered. Since noise is recognized as a hazard, hearing protection as PPE will not be the ultimate solution as a control measure. Hence, the Engineering Control must be identified and studied to be implemented as an ultimate solution to control the noise hazard in long term duration.
C130H aircraft
;
maintenance crew
;
noise exposure
10.Purslane protects against the reproductive toxicity of carbamazepine treatment in pilocarpine-induced epilepsy model
Al-Bishri Makhdour Widad ; Abdel-Reheim Salah Eman ; Zaki Reda Amr
Asian Pacific Journal of Tropical Biomedicine 2017;7(4):339-346
Objective:To investigate the protective effect of purslane with carbamazepine treatment.Methods:Male albino rats were modulated by pilocarpine to be epileptic.Both the normal and epileptic rats were treated with carbamazepine,purslane or carbamazepine plus purslane,with separate non-treated control groups for both normal and epileptic rats.Results:The data from the current study showed amelioration in amino acids and electrolytes in the epileptic rats treated with purslane and carbamazepine,with this amelioration occurring without decreasing the fertility hormones (testosterone,dehydroepiandrosterone,luteinizing hormone and follicle stimulating hormone).Purslane treatments also prevented the increase in estradiol.The decreased epileptic hyperexcitability with purslane was evidenced by decreased glial fibrillary acidic protein and lipid peroxidation.Conclusions:Natural products like purslane could be used with the highly repetitive drugs like carbamazepine to reduce or prevent its side-effects.