1.Radiation exposure to the surgeon during femoral interlocking nailing under fluoroscopic imaging.
T S Tengku Muzaffar ; Y Imran ; M A Iskandar ; A Zakaria
The Medical journal of Malaysia 2005;60 Suppl C():26-9
Femoral interlocking nailing requires fluoroscopic assistance for insertion of the nail and distal screws. In this study, scattered radiation to the eye and hand of the operating surgeon was measured during the procedure. Thermo-luminescent dosimeter (TLD) was used to quantify the dose received by the surgeon. The mean radiation exposure time during the procedure was 3.89 minutes. The mean scattered radiation doses to the hand and eye were 0.27 mSv and 0.09 mSv per procedure respectively. These very low doses have made a surgeon very unlikely to receive more than the recommended annual dose limit set by the National Council on Radiological Protection.
Radiation
;
Procedures
;
Millisievert
;
Hand
;
Eye
2.Differences in Utilisation of the General and Paediatric Emergency Departments by Paediatric Patients.
Jacqueline C L TAN ; Peck Har ANG ; Shu Ling CHONG ; Khai Pin LEE ; Gene Y K ONG ; Nur Diana Binte ZAKARIA ; Jen Heng PEK
Annals of the Academy of Medicine, Singapore 2020;49(12):948-954
INTRODUCTION:
Paediatric patients presenting to the general emergency departments (EDs) differ from those presenting to paediatric EDs. General EDs vary in preparedness to manage paediatric patients, which may affect delivery of emergency care with varying clinical outcomes. We aimed to elucidate the differences in utilisation patterns of paediatric and general EDs by paediatric patients.
METHODS:
This study was conducted in a public healthcare cluster in Singapore consisting of 4 hospitals. A retrospective review of the medical records of paediatric patients, defined as age younger than 16 years old, who attended the EDs from 1 January 2015 to 31 December 2018, was performed. Data were collected using a standardised form and analysed.
RESULTS:
Of the 704,582 attendances, 686,546 (97.4%) were seen at the paediatric ED. General EDs saw greater number of paediatric patients in the emergent (P1) category (921 [5.1%] versus 14,829 [2.2%];
CONCLUSION
General EDs need to build their capabilities and enhance their preparedness according to the paediatric population they serve so that optimal paediatric emergency care can be delivered, especially for critically ill patients who are most in need of life-saving and timely treatment.
3.The acetone crude extract of Quercus infectoria (Olivier) galls alters pH of the digestive vacuole of the malaria parasite, Plasmodium falciparum
Nik Mat Zin, N.N.I. ; Ibrahim, N. ; Zakaria, Y. ; Abu-Bakar, N.
Tropical Biomedicine 2021;38(No.2):40-47
The reduced efficacy of the mainstay antimalarial drugs due to the widespread of drugresistant
Plasmodium falciparum has necessitated efforts to discover new antimalarial drugs
with new targets. Quercus infectoria (Olivier) has long been used to treat various ailments
including fever. The acetone extract of the plant galls has recently been reported to have a
promising antimalarial activity in vitro. This study was aimed to determine the effect of the
Q. infectoria gall acetone crude extract on pH of the digestive vacuole of Plasmodium falciparum.
A ratiometric fluorescent probe, fluorescein isothiocyanate-dextran (FITC-dextran) was used
to facilitate a quantitative measurement of the digestive vacuole pH by flow cytometry. Mid
trophozoite stage malaria parasites grown in resealed erythrocytes containing FITC-dextran
were treated with different concentrations of the acetone extract based on the 50% inhibitory
concentration (IC50). Saponin-permeabilized parasites were analyzed to obtain the ratio of
green/yellow fluorescence intensity (Rgy) plotted as a function of pH in a pH calibration
curve of FITC-dextran. Based on the pH calibration curve, the pH of the digestive vacuole of
the acetone extract-treated parasites was significantly altered (pH values ranged from 6.35-
6.71) in a concentration-dependent manner compared to the untreated parasites (pH = 5.32)
(p < 0.001). This study provides a valuable insight into the potential of the Q. infectoria galls
as a promising antimalarial candidate with a novel mechanism of action.