1.Quetiapine-induced hypokalemic periodic paralysis in a pregnant woman: a case report
Muhammad Hafiz Mohamed PAUZI ; Azidah Abdul KADIR ; Syaheedatul Iman DINSUHAIMI ; Zainab Mat YUDIN ; Wan Nazirah Wan YUSUF
Korean Journal of Family Medicine 2025;46(2):115-119
Quetiapine-induced hypokalemic periodic paralysis (QIHPP) is a rare condition. Herein, we present the case of a 31-year-old pregnant Malay woman diagnosed with bipolar II disorder and QIHPP. She presented to the casualty department with a 2-day history of bilateral lower limb weakness and numbness. Her renal function tests showed moderate hypokalemia (2.5 mmol/L), whereas other investigations were normal. Quetiapine was suspected to be the cause, prompting a psychiatric referral to manage her acute condition. Balancing the risks of untreated QIHPP against the potential relapse of bipolar symptoms from quetiapine discontinuation or dosage reduction poses a significant treatment challenge for pregnant women with QIHPP. Finally, we reduced the quetiapine dosage after careful consideration, leading to the normalization of potassium levels and symptom resolution. Therefore, clinicians should be aware of this side effect when initiating or continuing quetiapine treatment in women of childbearing age or pregnant women with psychiatric disorders. It is crucial to monitor serum electrolytes, especially potassium, following quetiapine administration and warn patients about its potential side effects.
2.Quetiapine-induced hypokalemic periodic paralysis in a pregnant woman: a case report
Muhammad Hafiz Mohamed PAUZI ; Azidah Abdul KADIR ; Syaheedatul Iman DINSUHAIMI ; Zainab Mat YUDIN ; Wan Nazirah Wan YUSUF
Korean Journal of Family Medicine 2025;46(2):115-119
Quetiapine-induced hypokalemic periodic paralysis (QIHPP) is a rare condition. Herein, we present the case of a 31-year-old pregnant Malay woman diagnosed with bipolar II disorder and QIHPP. She presented to the casualty department with a 2-day history of bilateral lower limb weakness and numbness. Her renal function tests showed moderate hypokalemia (2.5 mmol/L), whereas other investigations were normal. Quetiapine was suspected to be the cause, prompting a psychiatric referral to manage her acute condition. Balancing the risks of untreated QIHPP against the potential relapse of bipolar symptoms from quetiapine discontinuation or dosage reduction poses a significant treatment challenge for pregnant women with QIHPP. Finally, we reduced the quetiapine dosage after careful consideration, leading to the normalization of potassium levels and symptom resolution. Therefore, clinicians should be aware of this side effect when initiating or continuing quetiapine treatment in women of childbearing age or pregnant women with psychiatric disorders. It is crucial to monitor serum electrolytes, especially potassium, following quetiapine administration and warn patients about its potential side effects.
3.Quetiapine-induced hypokalemic periodic paralysis in a pregnant woman: a case report
Muhammad Hafiz Mohamed PAUZI ; Azidah Abdul KADIR ; Syaheedatul Iman DINSUHAIMI ; Zainab Mat YUDIN ; Wan Nazirah Wan YUSUF
Korean Journal of Family Medicine 2025;46(2):115-119
Quetiapine-induced hypokalemic periodic paralysis (QIHPP) is a rare condition. Herein, we present the case of a 31-year-old pregnant Malay woman diagnosed with bipolar II disorder and QIHPP. She presented to the casualty department with a 2-day history of bilateral lower limb weakness and numbness. Her renal function tests showed moderate hypokalemia (2.5 mmol/L), whereas other investigations were normal. Quetiapine was suspected to be the cause, prompting a psychiatric referral to manage her acute condition. Balancing the risks of untreated QIHPP against the potential relapse of bipolar symptoms from quetiapine discontinuation or dosage reduction poses a significant treatment challenge for pregnant women with QIHPP. Finally, we reduced the quetiapine dosage after careful consideration, leading to the normalization of potassium levels and symptom resolution. Therefore, clinicians should be aware of this side effect when initiating or continuing quetiapine treatment in women of childbearing age or pregnant women with psychiatric disorders. It is crucial to monitor serum electrolytes, especially potassium, following quetiapine administration and warn patients about its potential side effects.
4.Quetiapine-induced hypokalemic periodic paralysis in a pregnant woman: a case report
Muhammad Hafiz Mohamed PAUZI ; Azidah Abdul KADIR ; Syaheedatul Iman DINSUHAIMI ; Zainab Mat YUDIN ; Wan Nazirah Wan YUSUF
Korean Journal of Family Medicine 2025;46(2):115-119
Quetiapine-induced hypokalemic periodic paralysis (QIHPP) is a rare condition. Herein, we present the case of a 31-year-old pregnant Malay woman diagnosed with bipolar II disorder and QIHPP. She presented to the casualty department with a 2-day history of bilateral lower limb weakness and numbness. Her renal function tests showed moderate hypokalemia (2.5 mmol/L), whereas other investigations were normal. Quetiapine was suspected to be the cause, prompting a psychiatric referral to manage her acute condition. Balancing the risks of untreated QIHPP against the potential relapse of bipolar symptoms from quetiapine discontinuation or dosage reduction poses a significant treatment challenge for pregnant women with QIHPP. Finally, we reduced the quetiapine dosage after careful consideration, leading to the normalization of potassium levels and symptom resolution. Therefore, clinicians should be aware of this side effect when initiating or continuing quetiapine treatment in women of childbearing age or pregnant women with psychiatric disorders. It is crucial to monitor serum electrolytes, especially potassium, following quetiapine administration and warn patients about its potential side effects.
5.Leptospirosis Knowledge, Attitude, and Practice of Town Service Workers in Kuching, Malaysia
Thung Senk Chung ; Shaiful Bahari Ismail ; Nani Draman ; Zainab Mat Yudin
Malaysian Journal of Medicine and Health Sciences 2024;20(No.1):234-241
Introduction: This study aimed to evaluate town service personnel’s knowledge, attitudes, and practices (KAP) regarding leptospirosis prevention and the influencing factors to its practice. Methods: A cross-sectional study was
conducted in Kuching, Malaysia, involving town service workers using a self-administered validated questionnaire
comprising sociodemographic and KAP information. The eligibility criteria included 18 years old and above and
having worked for more than six months. The KAP was determined using descriptive analysis, and associations were
identified using logistic regression analysis. Results: About 189 town service workers responded, giving a response
rate of 87.5%, and a majority of them were Bumiputera Sarawak, with a mean age of 38.6 (±11.00) years old. The
mean duration of employment was 9.3 (±6.99) years. About 88.9% had good knowledge of leptospirosis. Meanwhile, 85.2% and 79.9% had satisfactory attitudes and good practices. The knowledge on the aetiology of leptospirosis ranged from 25% to 94%. No significant association was found between the knowledge score and income with
the practice score. The attitude score (AOR 1.161; 95% CI = 1.090, 1.238; p = 0.000) and working experience (AOR
1.174; 95% CI = 1.023, 1.346; p = 0.022) were found to be significantly associated with their practice score. Conclusion: Most town service workers have good knowledge and practice regarding leptospirosis prevention. Workers
with good attitudes demonstrate good practising habits toward leptospirosis prevention. Awareness and activities
related to disease prevention should be encouraged to ensure the continuity of a positive attitude.
6.Type 2 diabetes remission: How does it work?
Faridah binti Mohd Zin ; Mohd Shahriman bin Ahmad Fuat ; Zainab binti Mat Yudin
Malaysian Family Physician 2021;16(1):124-128
Type 2 diabetes mellitus (Type 2 DM) is a chronic disease which rise is closely linked to the obesity
epidemic and which requires long-term medical attention to limit the development of its wideranged complications. Many of these complications arise from the combination of resistance to
insulin action, inadequate insulin secretion, and excessive or inappropriate glucagon secretion. The
increasing evidence of its remission state has been discussed in the literature. Here we report on a
patient with metabolic syndrome who underwent a structured therapeutic lifestyle changes (TLC)
therapy which eventually led to remission of Type 2 DM.
7.Oral Health Knowledge Among Family Physicians In Public Primary Healthcare Facilities In Malaysia
Khuzaimah Kamarazaman ; Norkhafizah Saddki ; Zainab Mat Yudin@Badrin ; Noraini Mohamad ; Zuliani Mahmood ; Norsiah Ali
Malaysian Journal of Public Health Medicine 2021;21(3):85-95
Integration of oral healthcare into primary care is recommended to improve the oral health of patients. This study assessed oral health knowledge among family physicians in Malaysia. A postal survey was done on family physicians working at the Ministry of Health primary healthcare facilities. Structured questionnaires containing 85 items assessing 5 sub-domains were delivered to 350 family physicians. A total of 138 responses were analysed. Most family physicians were able to identify the risk factors as well as signs and symptoms of dental caries, periodontal disease, and oral cancer, and recognize the link between oral diseases and general health, the oral side effects of medications, and the correct oral hygiene practices. However, misunderstandings were also common such as not knowing that dental caries is an infectious disease (56.5%) and a poorly fitting denture is a risk of oral cancer (60.1%) and having the misconception that the developing foetus draws calcium from the mothers’ teeth (60.0%). The mean knowledge score was significantly higher in physicians who had attended an in-service training program on oral health than those who had not. In conclusion, most family physicians in this study had adequate basic knowledge about oral health although some common misunderstandings in several issues. A significant relationship was found between oral health knowledge and experience of attending in-service oral health education programs. A structured continuous professional development program to improve oral health knowledge of family physicians and other primary healthcare providers is recommended.
8.A child with elbow pain
Zainab Mat Yudin@Badrin ; Wan Aireene Wan Ahmed ; Siti Balqis Chanmekun
Malaysian Family Physician 2019;14(2):44-45
Elbow injuries are common in children. Supracondylar fractures occurred in 16% of all pediatric
fractures. Supracondylar fractures can be classified into 4 types according to the Gartland
classification, depending on the degree of the fracture present in the lateral radiograph. This case
highlights the case of a child with a Gartland Type I fracture. A misdiagnosis of this fracture will
compromise the management of the injury with regards to immobilization and subsequent care. As
this injury can be managed on an outpatient basis, primary care frontliners need to be aware of the
condition.
9.Achievement of LDL Cholesterol Goal and Adherence to Statin by Diabetes Patients in Kelantan
Zainab Mat Yudin ; Lili Husniati Yaacob ; Norul Badriah Hassan ; Saiful Bahari Ismail ; Nani Draman ; Siti Suhaila Mohd Yusoff
Malaysian Journal of Medical Sciences 2017;24(3):44-50
Background: Statins are a class of potent drugs that can be used to reduce cholesterol,
especially low-density lipoprotein cholesterol (LDL-C). However, their effectiveness is limited
if adherence to treatment is poor. The objectives of the study are to estimate the proportion
of diabetic patient who has achieved LDL-C goal and to determine the association of LDL-C
achievement with socio demographic factors and statin therapy adherence
Methods: This is a cross-sectional study involving 234 patients with type 2 diabetes
mellitus (T2DM) and dyslipidaemia attending an outpatient clinic in a hospital in Kelantan.
Interviews and self-administered questionnaires were used to determine their sociodemographic
and clinical characteristics. Adherence to therapy was assessed using the Medication
Compliance Questionnaire (MCQ). The associations between the achievement of LDL targets
and sociodemographic/clinical factors, including adherence, were analysed with simple logistic
regression.
Results: About 37.6% of patients achieved their LDL-C target. The percentage of patients
who adhered to statin use was 98.3%, and 20.5% of these patients reported full adherence. There
was no significant association between achievement of LDL-C targets with adherence or any other
sociodemographic factors, such as age, gender and educational or economic status (all P-value <
0.05).
Conclusion: Despite a high level of adherence, the majority of patients failed to achieve
LDL-C targets. More concerted efforts are needed to improve this.


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