Pekanbaru is one of the cities in Riau Province which is an endemic area for Dengue Hemorrhagic Fever (DHF) with the Incidence Rate exceeding the endemic limit of 148,80 per 100.000 population. The purpose of this research was to determine the influence of the distance between houses, water storage condition, the existence of garbage, the existence of larvae around the houses. To determine attitude, knowledge, eradication of mosquito nests, the morning and or afternoon sleep habits, the habit of hanging clothes, and the existence of ornamental plants on Dengue Hemorrhagic Fever (DHF) cases. The type of research was observational quantitative analytic with a Case-Control design. The sampling technique used was Non-Probability Sampling and multivariate analysis used is multiple logistic regression. The sample was 138 respondents and Primary data collection using questionnaires and observation sheets. Six variables affecting the DHF cases were the existence of larvae (OR=8.103), eradication of mosquito nests (OR=6.230), water storage conditions (OR=2.136), the sleep habits in the morning and or afternoon (OR=2.058), the existence of garbage (OR=0.233) dan knowledge (OR=0.165). This suggests that the community can do eradicate mosquito nets. . Eradicating mosquito nests can be carried out through 3M Plus activities, including regularly draining the bathtub at least once a week, changing the water in flower vases, bird drinking places, or other water reservoirs regularly every less than one week. Closing water reservoirs tightly. Utilizing / recycling used cans, plastics, used tires, and other items that can hold rainwater so that they do not become mosquito breeding grounds. Six variables that influence the DHF cases, were: the existence of larvae, the action of 3M Plus, the condition of the water reservoir, the habit of sleeping in the morning and afternoon, the existence of garbage, and knowledge. Four variables did not affect the DHF cases, they were: attitude, the distance among houses, the habit of hanging clothes, and the existence of yard/ornamental plants. The community is expected to be able to recycle waste (garbage that has the potential to hold water).