1. Astrodaucus persicus as a new source of bioinsectisides against malaria vector, Anopheles stephensi
Saied GOODARZI ; Abbas HADJIAKHOONDI ; Narguess YASSA ; Zahra TOFIGHI ; Hassan VATANDOOST ; Mohammad Reza ABAI ; Saeed TAVAKOLI ; Amir HATAMIAN ; Yousef AJANI ; Abbas HADJIAKHOONDI ; Narguess YASSA ; Zahra TOFIGHI
Asian Pacific Journal of Tropical Medicine 2017;10(9):896-899
Objective To determine the larvicidal activities of petroleum ether, chloroform, ethyl acetate and methanol fractions of roots and fruits extracts of Astrodaucus persicus from Apiaceae family against malaria vector, Anopheles stephensi (An. stephensi). Methods Twenty five third instar larvae of An. stephensi were exposed to various concentrations (10–160 g/L) of fractions and were assayed according to World Health Organization protocol. The larval mortality was calculated after 24 h treatment. Results Among tested fractions, the highest larvicidal efficacy was observed from ethyl acetate fraction of fruits extract with 50% and 90% mortality values (LC
2.Isoimperatorin alleviates acetic acid-induced colitis in rats
Saied Goodarzi ; Amir Hossein Abdolghaffari ; Behnaz Najafi ; Mostafa Pirali Hamedani ; Saeed Tavakoli ; Mahshad Marvi ; Maryam Baeeri ; Narguess Yassa ; Abbas Hadjiakhoondi ; Mohammad Abdollahi ; Zahra Tofighi
Asian Pacific Journal of Tropical Biomedicine 2024;14(4):147-153
Objective: To investigate the effect of isoimperatorin on histopathological and biochemical changes in acetic acid-induced colitis rats. Methods: Colitis was induced by intracolonic administration of acetic acid solution (4% v/v) in rats. Rats were divided into six groups including the sham group, the negative control group, the dexamethasone-treated group, and the groups treated with isoimperatorin (0.1, 1, and 10 mg/kg/d by gavage). The treatments were administered for three days and then colonic status was assessed by macroscopic, histopathological, and biochemical analyses. Results: Isoimperatorin significantly alleviated colonic damage in a dose-dependent manner and improved histological changes in rats with acetic acid-induced colitis. It also significantly reduced myeloperoxidase, TNF-α, IL-1β, and malodialdehyde levels. Conclusions: Isoimperatorin alleviates acetic acid-induced colitis in rats and may be a potential therapeutic agent for the treatment of colitis.