Health Personnel ; psychology ; Humans ; Love ; Rare Diseases ; therapy

Objective To evaluate the efficacy and toxicity of gimeracil and oteracil porassium capsules combined with nedaplatin in the treatment of the patients with distant metastatic nasopharyngeal carcinoma.Methods Fourty cases were randomly divided into the observation group and control group by random digital table.19 cases in the observation group were treated with oteracil potassium capsules combined with nedaplatin.21cases in the observation group were treated with gemcitabine combined with nedaplatin.The response rate,response rate(RR) and progression free survival(PFS),toxicity were evaluated according to response evaluation criteria in solid tumors (RECIST).Results The response rate were 52.6％,52.3％ respectively,the median progression-free survival were 5.5 and 5.2 months,respectively.Grade Ⅲ an Ⅳ platelet supression were 10.5％,38.0％ between the observation group and control group.It was statistically significant between the two group(x2 =4.89,P ＜ 0.05).Conclusion Oteracil porassium capsules combined with nedaplatin is similar with gemcitabine combined with nedaplatin in the distant metastatic nasopharyngeal carcinoma,the adverse reaction was lighter than that of the control group.

Objective:To explore the relationship between serum uric acid (SUA) level and restenosis after percutane-ous coronary intervention (PCI) in patients with acute coronary syndrome (ACS) .Methods:A total of 389 patients , who were diagnosed as ACS and received PCI in our hospital from Jan 2010 to Dec 2013 ,were selected .The 82 pa-tients with hyperuricemia were regarded as hyperuricemia group ,and the remaining patients with normal SUA level were treated as normal SUA group (n= 307) .Clinical condition and restenosis after PCI were observed and com-pared between two groups .Results:Compared with normal SUA group ,there were significant rise in percentages of hypertension (41.04% vs .58.54% ) ,Killip> class Ⅰ (16.61% vs .26.83% ) and multi-vessel coronary disease (50.16% vs .64.63% ) ,restenosis rate after PCI (9.12% vs .15.85% ) in hyperuricemia group ,P<0.05 all .Con-clusion:Serum uric acid level is closely related to restenosis rate after PCI in ACS patients ,which is worth attention .

Corneal graft melting after keratoplasty is rare to happen.However,once corneal graft melting had happened,it is difficult to manage.It would be precluded effectively by confirming the risk factors and pathogenesis for corneal graft melting.Progression of graft melting also can be well controlled using immune depressant,heparin,or collagenase inhibitor at the early stage.Those patients with melted graft can be treated with repeat keratoplasty

The involution of female Swiss mouse thymus induced by estradiol (Es_2) were studied by morphological methods.The involuting thymuses of 2-month-old mice increased greatly in weight after ovariectomy. Treated with Es_2, the thymuses of immature mice not only stopped growing, and also involuted apparently. The regeneration of thymuses was impeded in the mice whose thymuses had already involuted induced by hydrocortisone when treated with Es_2. These results proved the obvious inhibiting and involution-inducing effects of Es_2 on thymus. The pattern of the thymus involution induced by Es_2 was different from that by hydrocortisone. Es_2 had no lethal effect on thymocytes either in vivo or in vitro, but it reduced the proliferative rate of thymocytes slowly and caused the thymus involution gradually. Es_2 made no remarkable changes in weight and histology of adrenal glands. Thymus involution induced by Es_2 was also detected in adrenalectomized mice. These results indicated that thymus involution induced by Es_2 was adrenal independent. Accompanying the thymus involution, the number of type Ⅰ thymic epithelial cells decreased, which were considered to produce thymic hormones actively, and the structure of thymic epithelial cells denatured. These morphological degenerative alterations suggest that Es_2 can result in some changes or decline of the hormone secretory activity of thymic epithelial cells, and then the proliferation of thymocytes will reduce and thymus involution will take place.

[Objective] To study Yi Pian of Su Wenand its author. [Method] Using the method of documents index and collection and research to make comprehensive texual research onYi Pian of Su Wento prove the origin from the aspect of term and verb and rhetoric and so on. [Result]Yi Pian of Su Wenis the work after Tang Dynasty,quoting fromXuan Zhu Mi Yu.The rhetoric of it is not the usage before Han Dynasty,for example,black corps,green corps,red corps and so on.We can see the usage of Jia Ling in the work,which was begun fromShang Han Za Bing Lunrather than Nei Jing.The understanding of Yun Qi theory inherited from the theory of Wang Bing.Many therapeutic methods were created by LIU Wenshu instead of WANG Bing orNei Jing. LIU Wenshu wroteSu Wen Ru Shi Yun Qi Lun Aowhich was based on seven sheets of Yun Qi and the theory of WANG Bing,possessing the theory basis ofYi Pian of Su Wen.[Conclusion] Thus we regarded theYi Pian of Su Wenas the work of LIU Wenshu who had made a great contribution to the theory of Five Yun and Six Qi.Su Wen Ru Shi Yun Qi Lun Aoclarified the truth of Yun Qi by plotting,creating Gan Zhi Qi Yun and Si Tian Jue. LIU Wenshu made the theory of Tian Di Jia Zi ,which was founded inXuan Zhu Mi Yu,as the theoretical foundation of'transformation of plague in three years'.He developed the theory and put forward the treatment method.

OBJECTIVE To investigate status of nosocomial infection in pancreas surgery of our hospital.METHODS The inpatient cases of pancreas surgery from Jan to Dec 2005 were prospectively and retrospectively surveyed.RESULTS Of the nosocomial infections,surgical site infection and the pulmonary infection were very prominent(78.2%),of the isolated strains the rate of bacterial pathogens was 85.90% and the rate of fungi was 14.10%,all strains were human normal intestinal bacterial species,the highest rate of infection was from patients with severe pancreatitis(29.41%),the pancreas surgery had higher multiple infection proportion(38.78%).CONCLUSIONS Rational application of antibiotic,intraoperative aseptic manipulation,short time operation,unobstructed drainage,prevention and timely treatment of pancreatic fistula and intraperitoneal hemorrhage,are the effective measures for the patients with pancreas surgery.

A retrieve of Pubmed database and China Journal Full-text Database was conducted to summarize the studies concerning the application of patch biomaterials in the inguinal herniorrhaphy. According to the chemical components and biological characteristics, the materials for the repair comprise unabsorbable materials, absorbable materials, composite materials and biological materials. Present research of patch materials focuses on the polypropylene polyester and expandable polytetrafluoroethylene. Patch implant is a kind of long-term chronic stimulation to the host. Local inflammation and continuous reaction severity can be affected by the type, quantity and surface area of the implants, together with the patch structure. Herniorrhaphy materials are doomed to develop towards a biomaterials with minimal invasion, light weight, absorption, easy operation, comfort and few complications. The patching method and material should be varying according to the disease type.

The scaffold material is one of the most key topics about the study of bone tissue engineering. The scaffold material of bone tissue engineering is divided into natural biomaterials and artificial synthesized biomaterials. Each kind of the materials includes organic materials and inorganic materials. Each scaffold material has its virtues and shortages. Although the existing scaffold materials merely carry some effects of the ideal materials require, the optimal scaffold may be designed using the necessary evidences provided by analyzing their virtues and shortages. This article summarized the study about the tissue engineering scaffold materials, such as porcelain and ceramics material, polymers material, natural organism-derived material and composite material.

BACKGROUND: There was degeneration in the dermis only,but not necrosis completely after deep burn or mixed Degree Burns. After treatment with auto-skin grafting,the denatured dermis will recover to normal or close to normal morphology and structure. OBJECTIVE: To comparatively analyze the long-term effect of repair of deeply burned in function regions with large sheet of split-thickness auto-skin grafting with the preservation of denatured dermis or not during eschar shaving. DESIGN,TIME AND SETTING: A case analysis was performed in Department of Burnt Surgery of Dongguan Qingxi Hospital from March 2006 to June 2008. PATICIPANTS: Fifty-eight patients with deep burn in function regions were randomly divided into three groups according to different therapy ways. METHODS: The denatured dermis of patients in derma excised group was cut completely during eschar shaving and large sheet of split-thickness auto-skin was transplanted. The necrotic crust was cleared away with pare scab or scrape scabby method and reserved the denatured derma in derma reserved group. The patients who did not agree to operating skin transplanted on clinic served as control group,and they were treated with dressing change means till wound healing. MAIN OUTCOME MEASURES: Comparison of the bleeding volume in operation and scar proliferation after operating among the three groups,and evaluation the grade of the function. RESULTS: The bleeding volume in derma reserved group was less than that in dermis excised group during the operation. The survival rate of grafting skin in derma reserved group was lower than that in derma excised group. The shrinkage of grafting skin in derma excised group was more obvious than that in derma reserved group,and the long-term function would be worse than that in derma reserved group. The scar proliferation in control group was most obvious and the recovery of function was worst among the three groups. CONCLUSION: The good show and function was obtained to recovery of deep burn in function regions with large sheet of split-thickness auto-skin grafting and the preservation of denatured dermis during eschar shaving.