Objective To investigate the effects of different anesthesia methods on cerebral oxygen metabolism in patients with severe traumatic brain injury.Methods Forty-five patients with severe traumatic brain injury from March 2011 to March 2013 were divided into propofol intravenous anesthesia group(group A),sevoflurane inhalation anesthesia group(group B) and intravenous inhalational anesthesia group (group C) by random digits table method with 15 cases each.The mean artery pressure (MAP),heart rate (HR) before anesthesia,immediately after tracheal intubation,2 minutes after intubation,10 min and 30 min after operation set and operation end were observed.The oxygen content of jugular venous (SjvO2),jugular bulb venous oxygen content (Da-jvO2) and cerebral metabolic rate for oxygen (CERO2) before anesthesia induction,immediately finish anesthesia induction,30 min and 1 h after operation set and operatin end were calculated.Results The SjvO2 values in three groups were at 30 min,1 h after operation set and operation end was higher than that before anesthesia induction (group A:0.662 ±0.077,0.689 ±0.067,0.685 ±0.066 vs.0.623 ±0.083; group B:0.661 ±0.074,0.681 ±0.072,0.661 ±0.069 vs.0.598 ±0.092; group C:0.715 ± 0.072,0.743 ± 0.070,0.713 ± 0.075 vs.0.631 ± 0.078),and there was significant difference (P ＜ 0.05).The Da-jvO2 values,CERO2 at 30 min,1 h after operation set and operation end was lower than that before anesthesia induction in three groups [group A:Da-jvO2:(41.2 ± 6.3),(41.6 ± 8.1),(44.2 ± 6.3) ml/L vs.(49.2 ± 9.2) ml/L,CERO2:(33.0 ± 1.9)％,(32.7 ± 2.0)％,(32.3 ± 1.9)％ vs.(36.0 ±2.3)％; group B:Da-jvO2:(41.8 ± 5.6),(40.2 ± 6.9),(41.8 ± 5.6) ml/L vs.(51.3 ± 8.6) ml/L,CERO2:(33.2 ±2.1)％,(33.0 ±2.6)％,(32.8 ±2.1)％ vs.(34.7 ±3.1)％ ; group C:Da-jvO2:(39.5 ±6.8),(38.7 ±7.0),(40.2 ±6.8) ml/L vs.(48.8 ±9.7) ml/L,CERO2:(31.8 ±2.9)％,(31.5 ±3.1)％,(32.9 ±2.3)％ vs.(35.1 ± 2.9)％],and there was significant difference (P ＜ 0.05).And group C was decreased more significantly (P＜0.05).There was no significant difference in MAP,HR among three groups (P＞0.05).Conclusion Propofol intravenous anesthesia and sevoflurane inhalation anesthesia can effectively reduce perioperative cerebral metabolic rate of oxygen,and the balanced anesthesia has better cerebral protection with the stable hemodynamic.

Obesity is associated with numerous metabolic abnormalities, including insulin resistance and type 2 diabetes. Losing weight is an effective way of improving insulin sensitivity, thus decreasing the risk of obesityassociated diabetes and chronic cardiovascular disease. There is evidence that Liraglutide, as a human glucagon-like peptide-1 ( GLP-1 ) analogue, either using alone or combining with other glucose-lowering drugs, has effect on improving glycemic control, protecting β-cell function, and reducing body weight via inhibiting feeding behavior and delaying gastrointestinal motility. Therefore, liraglutide is a new option for treating type 2 diabetes patients.

Objective To investigate the clinical effect of early laparoscopic cholecystectomy in the treat -ment of elderly patients with acute cholecystitis .Methods 68 elderly patients with early acute cholecystitis were di-vided into the two groups according to the surgical procedures .33 cases in OC group were given traditional open sur-gery,while 35 cases in LC group received early laparoscopic cholecystectomy .The operative time,postoperative bowel recovery time and postoperative hospital stay time were compared between the two groups .Results The operative time,postoperative bowel recovery time ,postoperative hospital stay time in LC group were (43.7 ±5.8)min,(36.4 ± 3.9)h,(4.8 ±1.4)d,which were significantly shorter than (68.6 ±7.3)min,(65.2 ±4.5)h,(8.3 ±2.9)d in the OC group(t=3.317,3.862,3.029,all P<0.05).The incidence rate of postoperative complication of LC group was 14.29%,which of the OC group was 24.24%,the difference was not significant(P>0.05).Conclusion Early lap-aroscopic cholecystectomy in the treatment of elderly patients with acute cholecystitis can significantly shorten the operation time, promote postoperative recovery of gastrointestinal function and reduce postoperative hospital stay , reduce the burden of patients ,improve the quality of life and the incidence rate of complications is low .

Objective To quantitatively detect CA125 with self-designed synthetic gold nanoparticle probes by the colorimetric immunoassay and to initially investigate the feasibility of clinical application .Methods The capture antibody of detective CA125 was conjugated to the gold nanoparticle surface for preparing the gold nanoparticle probes .The gold nanoparticle aggregation was formed by the antigen-antibody immunoreaction .CA125 was quantitatively detected by the colorimetric immunoassay .Results The gold nanoparticle probes was successfully prepared ,which could detect the serum CA125 content rapidly and conveniently ,the de-tection results were coincident with the pathological diagnosis .The lowest limit of quantitation was 0 .5 U/mL ,which was far lower than that in ELISA .Conclusion This gold nanoparticle probes are simple to be prepared ,rapid and easy to operate with low cost , and have the important application value in clinical early detection of ovarian cancer marker CA 125 ,especially in the primary hospi-tals .

Hyperoxia-induced lung injury in neonatal is a common complication after the clinical high oxygen therapy. There is not specific and effective prevention and treatment. Recent research suggests that many factor play an important role in the repair and protection of hyperoxia-induced lung injury in neonatal, such as growth factor, bone marrow mesenchymal stem cells,erythropoietin, anti-chemokine and anti-oxidation. The article reviews the molecular systems mechanisms in the pathologic process of hyperroxia-induced lung injury in neonatal.

1,25-dihydroxyvitamin D3 plays a role in the regulation of T cells, B cells, macrophages,dendritic cells,and keratinocytes. 1,25-dihydroxyvitamin D3 is linked to many autoimmune diseases, including rheumatoid arthritis,juvenile diabetes, Crohn's disease, multiple sclerosis. It may have potential as a treatment for autoimmune diseases, however, additional research will focus on better quantify dosage and course of treatment.

Retrospective analysis of 30 cases of penetrating keratoplasty in children followed- up 3 months to 3 years found that 46.7% of the grafts were clear and 53.3% were failures.The younger the children,the higher was the risk of failure,especially amo- ng cases of combined operations.

Spiritual motivation is the basic means of mental reconstruction and behavior improvement.Medical ethics education is a process that fully develop medical resources,mine the essence of western traditional thinking of medical ethics,teach the basic principles of medical ethics,and medical ethics norms,play the role of medical model,train the noble medical ethics emotion,and develop good medical ethical behaviors.Based on the present situation of medical ethics education,this article explores the features of spiritual motivation and its application.

OBJECTIVE:To provide reference for building harmonious pharmacist-patient relationship and standardizing the legal responsibility induced by drug injury events.METHODS:The related concepts such as the drug injury events and adverse drug reactions were compared and defined;the legal nature of the drug injury events was clarified and the legal responsibility arose from the drug injury events was analyzed.RESULTS & CONCLUSIONS:Drug injury events as a legal fact can result in the emergence,change and elimination of the civil legal relationship between pharmacists and patients.The legal responsibility arose from the drug injury events include tort liability,administrative liability and criminal liability.

OBJECTIVE:To discuss the irrational combined use of traditional Chinese with western medicines to provide basis for clinical safe medication. METHODS:Referring to the domestic pertinent literature together with our clinical experiences, some common and typical incompatibility between the traditional Chinese medicines and western medicines were analyzed, sorted and classified and summarized to derive the mechanism for the incompatibility. RESULTS & CONCLUSION:Irrational combined use between traditional Chinese medicines and western medicines can result in lower curative efficacy and higher toxic effect or even severe drug-induced diseases that may lead to serious consequences, therefore, great importance should be attached to this matter.