OBJECTIVE To explore the reason,hazard and preventive method of sharp injuries by analyzing nursing students who had sharp injuries.METHODS A retrospective study of hospital medical sharp injuries were taken among nursing students from Aug 2007 to May 2008.RESULTS There were 30 cases sharp injuries occurred in past year.Needles injuries accounted for 76.7%,and the others for 23.3%.Fifteen cases occurred in operation,and 15 cases occurred after operation.Twenty-three cases worked without gloves;86.7%injuris were on fingers.Hepatitis Bvaccine inoculation rate was 63.3% in 30 cases.CONCLUSIONS Enhancing occupational security education,improving nursing students′ sense of occupational security prevention and standardizing operation progress,can decrease sharp injuries among nursing students.

Objective To design a neonatal nasogastric fixation mount to decrease the complications during nasogastric feeding and facilitate the nurse's operation.Methods The mount was composed of a base,a hose rack,a clamp,a freelyrotating roll ball and a fixation knob.Totally 90 preterm infants hospitalized from January to September 2016 were equally and randomly divided into a fixation mount group,a gravity feeding group and a control group using conventional nasogastric feeding.The incidences of the complications during feeding were recorded including emesis,abdominal distension and apnea,and questionnaire survey was carried out on the nurse's satisfaction for the fixation mount.Results The mount reduced the complications related to nasal feeding,increased the nurse's satisfaction.The fixation mount group had the complications incidence rate (30.0％) significantly lower than those of the gravity feeding group (43.3％) and the control group (53.3％).The nurse's satisfaction in the fixation mount group (93.3％) was higher than those in the gravity feeding group (80.0％) and control group (52.0％).Conclusion The nasograstric fixation mount is applicable for the preterm infants in far-infrared radiation table,warmer and infanette,and thus is worthy promoting clinically.

Objective To investigate the therapeutic effect of traditional Chinese medicine,Songling Xuemaikang Capsule on the individual with cerebral infarction reconvalescent and its mechanism.Methods Patients in control group( n =54) received regularly therapy and treatment group( n =55) was treated with regularly therapy and Songling Xuemaikang Capsule for eight weeks respectively.The clinical therapeutic effeets,Barthel index,hemorheology indexes,serum lipid and C-reactive protein (CRP) were determined.Results The total clinical effective rate in treatment group and control group was 70.9％ and 55.6％ (P ＜ 0.01 ).After eight weeks treatment,the scores of Barthel Index,hemorheology indexes,the amounts of serum lipid and CRP in treatment group were improved significantly as compared to the control group ( P ＜ 0.05 or P ＜ 0.01 ).There was no severely side effect found in this trial.Conclusion Songling Xuemaikang Capsule could partly improve patients clinical outcome and life quality.The clinical efficacy of Songling Xuemaikang Capsule on the individual with cerebral infarction reconvalescent should be related to its functioning to promote the recovery of patients' blood hemorheology,and regulate serum lipid and decrease CRP level.

Objective To analyze the clinical distribution and antimicrobial resistance of Acinetobacter baumannii (A.baumannii)from a hospital,so as to guide the rational use of antimicrobial agents and provide scientific basis for the prevention and control of healthcare-associated infection(HAI).Methods Distribution and antimicrobial susceptibility testing results of A.baumannii isolated from patients between January 2011 and December 2013 were analyzed retrospectively.Results A total of 339 A.baumannii isolates were isolated within three years,291 iso-lates (85.84%)were from sputum,followed by urine (n=29,8.55%),secretion(n=12,3.54%)and blood (n=3,0.89%).The main distribution departments were intensive care unit(ICU,n=149,43.95%),department of re-spiratory medicine (n=46,13.57%),department of pediatrics (n =32,9.44%)and oncology (n =22,6.49%). The resistant rate of A.baumannii to tobramycin and imipenem were 11 .11 %-49.47%,the resistant rates to the other antimicrobial agents were relatively high;antimicrobial resistant rate of 2012 and 2013 were obviously lower than 2011 .Conclusion A.baumannii from this hospital are mainly from sputum specimens,and mainly distribute in ICU and department of respiratory medicine,antimicrobial resistant rate is high,but there is a decreasing tenden-cy in recent years.

Objective To investigate the effect of batroxobin on the plasma levels of endothelin (ET) and calcitonin gene-related peptide(CGRP) in patients with acute cerebral infarction(ACI). Methods 60 patients with ACI were randomly divided into therapy group(n = 30) and control group(n = 30),500 ml of 5% GS plus 1.0g ramme of Troxerutin was intravenously dripped par day and ticlopidine 250mg/day in the control group. Based on the control group therapy,Batroxobin was intravenously dripped with 10U on the 1st day and 5U on the 3rd and 5th day for seven days. The plasma levels of ET and CGRP were detected pre and post treatment by radioimmunoassay. Results Plasma levels of ET and CGRP in batroxobin therapy group post treatment ( 81.25±27.38 ) ; ( 44. 13±13.30) ng/L were significantly different from those pre treatment(109. 83±38.24) ; (24. 73±13.59) ng/L (all P＜0. 01 ) ,and were also significantly different from those post treatment in the control group(98.07±30. 39) ; (37.02±12. 41 )ng/L (all P＜0. 01 ). Conclusion Batroxobin can accommodate the equilibration between ET and CGRP, and protect brain cell and blood vessel endothelial cell.

The effects of polysaccharidical peptides (PSP) on the functions of tumour infiltrating lymphocytes (TILs) in vitro was explored. The results showed that PSP, at the concentration of 37-1200?g/ml, promoted the proliferation of TILs in dose-related manner. Combination of PSP with interleukin-2 (IL-2) enhanced the cytotoxicity of TILs and reduced the dose of IL-2 used for activating TILs. The results suggested that PSP could augment the proliferation and cytotoxicity of TILs in vitro.

[ ABSTRACT] AIM:To investigate the effects of everolimus on the experimental IgA nephropathy in rats and its possible mechanisms .METHODS:The rat model of experimental IgA nephropathy was established .The rats were ran-domly divided into control group , IgA group and everolimus treatment group .After the corresponding treatments were gi-ven, urinary red blood cells , protein and N-acetyl-β-D-glucosaminidase ( NAG) were examined .Immunofluorescence stai-ning was used to analyze the level of IgA precipitation in the renal tissues .Additionally, the protein expression of myeloid differentiation factor 88 (MyD88), TLR4, NF-κB, IL-4 and IL-13 was determined by Western blot.The mRNA levels of IL-4 and IL-13 were detected by qPCR .RESULTS:Everolimus significantly inhibited the increases in the urinary levels of red blood cells, protein and NAG in experimental IgA nephropathy rats .Furthermore, IgA nephropathy-induced increases in the protein expression of MyD88, TLR4, NF-κB, IL-4 and IL-13 were attenuated after everolimus treatment .Similar re-sults were obtained in the mRNA levels of IL-4 and IL-13 by qPCR detection .CONCLUSION: Everolimus improves the impairments of renal function in experimental IgA nephropathy rats as evidenced by decreasing urinary red blood cells , pro-tein and NAG, which may be related to the inhibition of MyD 88, TLR4, NF-κB, IL-4 and IL-13 expression.

Background and purpose:Internal mammary sentinel nodes (IMSNs) lymphoscintigraphy could guide in ?-detecting and removing the IMSNs for the purpose of biopsy during the operation,which is helpful to determine the necessity of postoperative radiotherapy. However,IMSNs imaging rate remains low if using axillary lymph nodes (ALNs) lymphoscintigraphy. This study was to investigate the tracer’s properties and try to improve the IMSNs imaging rate through changing the label procedure. Methods:The boiling time of 99mTC-sulphur colloidal particles was shortened from 3~5 minutes to 2 minutes during the label procedure, then the colloidal particles’ diameter, distribution and stability were observed by Transmission Electron Microscope (TEM), then the IMSNs lymphoscintigraphy was performed. Results:This colloidal tracer’s shape and distribution remained stable for 3 hours, and 90% of the particles had a diameter of 10 nm, the particles tended to aggregate afterwards. 4 hours after labeling, the diameter of particles exceeded 100 nm. IMSNs could be clearly imaged if the tracer was freshly used (within 3 hours after labeling). Conclusion:Within 3 hours after the labeling the unfiltered colloidal tracer with modified procedure, the particle could be used and internal mammary lymph nodes could be imaged more clearly.

Objective: To explore the attitude and its influencing factors of patients with cancer towards information disclosure.Methods: 302 patients with cancer were investigated with self-designed questionnaires.Results: The patients' attitudes towards Information Disclosure were significantly affected by the gender,marriage status,personality,duration of cancer information,hospitalization experience and funeral experience,with significant statistical differences﹝P

Objective To explore the relationship between β2-microglobulin and D-Dimer concentration in the pregnancy-induced hypertension patients with kidney injury.Methods The 120 cases of kidney injury pregnancy-induced hypertension patients were enrolled in our hospital from Nov 2010 to Nov 2015 (served as observation group).The levels of BUN,Scr,UA,β2-microglobulin and D-Dimer were detected.The 100 cases of healthy subjects and 120 cases of normal pregnancy women were taken as controls,respectively.Results Compared with healthy control and normal pregnancy women,the levels of BUN,Scr,UA were increased significantly in the observation group (P<0.05).The results also showed that the expression of NGAL,NLRP3,NADPH oxidase subunits,TGFβ,Smad2,Smad3,β2-microglobulin and D-Dimer were sharply increased as compared with the other two group (P<0.05).Conclusion β2-microglobulin and D-Dimer are significantly related with pregnancy-induced hypertension patients with kidney injury and they would be taken as clinical indicators for the diagnosis of this disease.