1.An Effect Analysis of Rehabilitation Treatment on Inpatients with Stroke
Chinese Journal of Rehabilitation Theory and Practice 1999;5(1):28-30
Using UEDASATO’s Evaluation and MAS (Motor Assessment Scale), We analysed the effect of hemiplegic patients following stroke who received three month rehabilitation treatment early after attacks. Results showed that the function recovery of effected limbs was worse than that of lower limbs, and the difference was statistically signicant (P<0.05); the whole motor function embodied in the trunk controlling and walking ability was improving after treatment, and there was obvious difference between pre and post treatment (P>0.05); there was little function recovery in effected upper limbs, no obvious difference was found (P<0.05). We concluded that the function recovery of the lower limbs in hemiplegic patients.
2.Study of the Influence on Hemipl egic Patients Treated with Rehabil itation Medicine Sooner or Later
Chinese Journal of Rehabilitation Theory and Practice 1996;2(2):66-69
hemiplegic patients following stroke were devided into two groups一一group A andgroup B for this study. Rehabilitation treatment started for the patients in group A in one month,yet forthose in group B in two or three months after onset of the stroke. Compared the conditions of the twogroups of patients before their rehabilitation treatment,there was no obvious difference(P<0.05)in thefour aspects of their motor ability(Ⅰ-activity in bed;Ⅱ-aclivity in wheel-chair;Ⅲ-in-ward;Ⅳ-outdoor activity).While the result of analysis on their post-treating shift of motor ability showed that thetrend,which the proportion of patients with ability Ⅰ andⅡ decreased but the proportion of patients withability Ⅲ and Ⅳ increased,was more significant in group A than in group B(P<0.05).Thereby it indicatesthat the early starting of rehabilitation treatment is favourable for improving motor ability of hemiplegic pa-tients following stroke.
3.The expression and clinical significance of mTOR/P70S6K signaling pathway in cervical cancer
Jing JI ; Tingting GU ; Pengsheng ZHENG
Journal of Xi'an Jiaotong University(Medical Sciences) 2010;31(1):10-13
Objective To evaluate the expression and function of mammalian target of rapamycin (mTOR) and its substrate kinase P70S6K in mTOR/P70S6K signal pathway in cervical carcinogenesis. Methods The expression of mTOR and P70S6K in normal cervix uteri or cervical cancer was detected by the immunohistochemistry and RT-PCR methods. Results Compared to those in normal cervix uteri, both mRNA and protein of mTOR/P70S6K in cervical carcinomas were significantly increased (P<0.05). There was a positive correlation between mTOR gene and P70S6K gene expression in cervical cancer (r=0.746, P<0.001). Conclusion High expression of mTOR and P7OS6K may play an important role in the pathogenesis and development of cervical cancer.
4.Clinical analysis of infective endocarditis complicated with intracranial hemorrhage
Lingling YU ; Tingting ZHENG ; Deping LIU
Chinese Journal of General Practitioners 2016;15(5):371-374
Objective To analyze the clinical characteristics of infective endoearditis complicated with intracranial hemorrhage.Methods The clinical characteristics,brain CT and MRI results and prognosis of 7 patients with infective endocarditis and intracranial hemorrhage admitted between January 1991 and May 2015 were retrospectively analyzed.Results All seven patients presented varying degrees of fever,cardiac murmur and neurological symptoms.The continuous fever lasted from 21 d to 227 d (average 91 d).Mitral valve (4 cases) and aortic valve (3 cases) were the most common affected ones.The brain CT or MRI scan presented intracranial hemorrhage in 6 cases.More than 2 hemorrhage locations were found in 5 patients and parietal lobe was most common one (4 cases).All patients were treated with antimicrobial agents and three patients underwent valve replacement surgery.Three patients were cured and another 2 died due to fatal hemorrhage.Conclusions Patients with long fever history and ineffective antimicrobial treatment are prone to intracranial hemorrhage.Brain CT or MRI scan need be performed in infective endocardits when neurological symptoms are present,and brain angiography should be also considered if necessary.
5.Efficacy and Safety of Different Doses of Canagliflozin in the Treatment of Type 2 Diabetes:A Meta-analysis
Shuai ZHANG ; Tingting ZHENG ; Guoying CAO
China Pharmacy 2016;27(3):358-361
OBJECTIVE:To systematically review the efficacy and safety of different doses of canagliflozin in the treatment of type 2 diabetes,and provide evidence-based reference for the clinical treatment. METHODS:Retrieved from PubMed,Cochrane Library,Clinical Trails.gov,CJFD,Wangfang Database and VIP,randomized controlled trials (RCT) about different doses of canagliflozin in the treatment of type 2 diabetes were collected. Meta-analysis was performed by using Rev Man 5.3 software after data extract and quality evaluation by Cachrane 5.10. RESULTS:Totally 11 RCTs were enrolled,involving 5 399 patients. Results of Meta-analysis showed,canagliflozin 300 mg/d were superior to 100 mg/d in reducing HbA1c[MD=0.14,95%CI(0.09,0.19), P<0.001],FPG[MD=0.40,95%CI(0.20,0.61),P<0.001] and reduction rate of body mass[MD=0.69,95%CI(0.42,0.96),P<0.001],the differences were statistically significant;and there were no significant differences in the incidence of total adverse reac-tions [RR=0.97,95%CI(0.94,1.01),P=0.10],hypoglycemia [RR=1.02,95%CI(0.94,1.10),P=0.67],urinary tract infection[RR=0.96,95%CI (0.78,1.18),P=0.69] in 2 groups;There was significantly different of genital mycotic infection in 2 groups[RR=0.84,95%CI(0.70,1.00),P=0.04]. CONCLUSIONS:Canagliflozin 300 mg/d is better than 100 mg/d in controlling HbA1c,fasting blood glucose and body mass of patients with type 2 diabetes,and the genital mycotic infection should be attentioned.
6.Thiazolidinediones combined with metformin in treatment of polycystic ovary syndrome:a systematic review
Tingting HAN ; Jun ZHENG ; Yaomin HU
Academic Journal of Second Military Medical University 1981;0(04):-
Objective To assess the efficacy and safety of thiazolidinediones combined with metformin in treatment of polycystic ovary syndrome.Methods Electronic database searching was performed on Medline,Cochrane Library,EMbase,EBSCO,ScienceDirect,OVID,Springer LINK,Wiley,Chinese biology and medicine(CBM),China National Knowledge Infrastructure(CNKI),and Chongqing VIP Database;meanwhile,unpubished literature,conference papers and dissertations were also searched manually.The data included those from the establishment to November 2009.Randomized or clinical controlled trials concerning the thiazolidinediones and metformin combination therapy for PCOS were selected and assessed for the methodological quality,and Meta-analysis was performed using statistical software Revman 5.0.Results Five randomized controlled trials met the inclusion criteria and were included.Compared to metformin group,thiazolidinediones combined with metformin significantly improved insulin resistance(P
7.Determination of Related Substances in Lumefantrine by Gradient Elution RP ̄HPLC
Tingting HE ; Jinqi ZHENG ; Qiaofeng TAO ; Guogang ZHENG ; Yuxin CEN
Herald of Medicine 2015;(11):1489-1492
Objective To establish a gradient RP ̄HPLC method for determining the related substances in lumefantrine. Methods The HPLC analysis was performed on an Agilent nucleosil 100 ̄5 C18(4.0 mm×125 mm,5 μm) column;the mobile phase was consisted of solution A,B and C,which included phosphate buffer solutions (consisting sodium hexane sulfonate,pH was adjusted to 2. 3 ) ̄water ̄acetonitrile ̄propanol with different proportion, with a gradient elution at the flow rate of 2.0 mL.min-1 , the detection wavelength was 265 nm, and the column temperature was 35 ℃ . Results An excellent separation achieved for lumefantrine from its related substances.Lumefantrine had a good linear relationship with the peak area within the range of 0.173 4-0.693 2 μg.mL-1(r= 0.999 6).The limit of determination was 0.06 μg.mL-1 . Conclusion The method is sensitive,reproducible and specific for the separation and determination of related substances in lumefantrine.
8.Three-dimensional finite element simulation and biomechanical analysis of mandible chin blast injury
Tao LEI ; Jiajun ZHENG ; Tingting WANG ; Ying LI ; Liangxian XIE
Chinese Journal of Trauma 2015;31(11):1050-1055
Objective To simulate a finite element model for biomechanical analysis of mandible chin blast injury and analyze the mechanism of maxillofacial blast injury.Methods The three-dimensional element model of human mandible blast injury was established to simulate the dynamic process of injury to the mandible chin.Von Mises stress and effective strain were evaluated in biomechanical study of the simulation results.Results The dynamic damage process of human mandible chin blast injury was simulated successfully.In the condition of 1 000 mg and 3 cm,the Von Mises stress and effective were maximum at condylar neck region (9.1 × 106 Pa,0.62 × 10-3ε),were second at mandibular angle region (6.1 × 106 Pa,0.42 × 10-3ε),and minimum at mental foramen region (6.1 × 106 Pa,0.39 × 10-3ε).Blast distance rather than blast equivalent produced more effect on the mechanical parameters and damage degree.Conclusions Von Mises stress and effective strain can be applied to the evaluation of bone tissue damage.The finite element method is effective in simulating mandible blast injury and can provide a new thought and approach to clinical treatment of oral and maxillofacial blast injury.
9.Establishment and simulation validation of a three-dimensional finite element model of pig mandible impact injury
Tao LEI ; Ying LI ; Jiajun ZHENG ; Tingting WANG ; Liangxian XIE
Chinese Journal of Trauma 2015;31(8):743-747
Objective To develop a three-dimensional element model of pig mandible impact injury and test the simulation results in an attempt to determine the feasibility and reliability of finite element numerical simulation method used in the maxillofacial impact injury.Methods CT data was used to develop a three-dimensional finite element model of pig mandible impact injury,and the dynamic process of impact injury was simulated.The simulation results were compared with the animal experiment and had energy check to validate the reliability and feasibility of the modeling and simulation methods.Results The three-dimensional finite element model was established successfully,containing 61,512 hexahedrons,5,450 tetrahedrons,4,030 trihedrons,and 67,159 nodes.The simulation process was realistic,and the simulation results showed no statistical difference with the animal experiment with regard to strain,acceleration,and other biomechanical properties (P > 0.05).The simulated damage shape had a high similarity with animal specimens,and the result of energy check also complied with energy conservation law.Conclusion Finite element method is effective to simulate the dynamic process of mandible impact which ensures a correct and reliable model and simulation,and thus can be used to analyze the mechanism of maxillofacial impact injury.
10.Clinical Significance of Serum TSAb and TSBAb in Children with Autoimmune Thyroid Disease
Juan HE ; Geli LIU ; Tingting LIU ; Qingyan YANG ; Rongxiu ZHENG
Tianjin Medical Journal 2014;(11):1100-1102
Objective To study clinical value and significance of thyroid receptor stimulating antibody (TSAb) and thyroid stimulating-blocking antibody (TSBAb) on diagnosis and treatment for children with Graves’disease (GD) and Hashimoto’s thyroiditis (HT). Methods Eighty-eight children with autoimmune thyroid disease (AITD) and treatment time less six months were divided into GD group (n=55) and HT group (n=33). Thirty-eight healthy children were used as control (Normal group). Human serum TSAb ELISA kit and human TSBAb ELISA kit were used to detect the serum TSAb and serum TSBAb in three groups. The serum levels of TSAb and TSBAb were compared between three groups. The correla? tion between TSAb and TSBAb, TSAb/TSBAb and free triiodothyronine three (FT3), free thyroxine (FT4), ultra sensitive thy?roid stimulating hormone (TSH) were analyzed. Results The serum level of TSAb was significantly higher in GD group than that of HT group and Normal group (P<0.05). The serum level of TSBAb was significantly higher in HT group than that of Normal group (P<0.05). There was no significant correlation between serum TSAb and serum TSBAb (P>0.05). There were no significant correlation between serum TSAb, TSBAb and FT3, FT4, TSH (P>0.05). Conclusion TSAb and TSBAb are related to the pathogenesis of GD and HT in children. TSAb and TSBAb have an important clinical value in the diagnosis and treatment for children with GD and HT.