The objective of study was to investigate the influence of alcohol concentration and amount,soaking time on extraction rate from Rhizoma Atractylodis Macroephalae with the method of uniform design. We concluded that this method has potential as a good method for experiment design with many factors during the screening of optimum extraction process of Chinese medicine preparations.

Objective:To discuss the effect of optimum program on hypertensive cerebral hemorrhage in acute phase.Methods:380 patients with hypertensive cerebral hemorrhage were selected.They were randomly divided into test group by given two agents(Xuezhongxiao/Zhongfengfangzhiling)+comprehensive rehabilitation(rehabilitation of modern acupuncture)+ medicine-based treatment +microinvasive surgical therapy,and control group by given Chinese medicines(Xuekang /Naoan capsule) + modern rehabilitation+ medicine-based treatment + craniotomy treatment.The curative effects was observed and compared between the two groups.Results:The test group was evidently superior to the constrol one in haematoma clearance rate,nerve functions recovery,extremity rehabilitation and symptoms improvement(P

Objective To discuss the matching method of irregular device for radiological equipment. Method Related experiences were summed up. Result A set of interventional protective device matching DSA was developed through tripartite corporation. Conclusion The matching method is beneficial to equipment management.

Objective To optimize the adsorption and desorption conditions for total alkaloids from Cortex Phellodendri with AB-8 macroporous resin.Methods With the adsorption and desorption volume of total alkaloids as the observation indexes,the experiment of dynamic adsorption with AB-8 macroporous resin was carried out to observe the effect of the sample volume,flow rate,water volume for removing impurity,and the concentration and volume of eluant on the total alkaloids from Cortex Phellodendri.Results The optimal adsorption conditions were as follows:sample volume being 50mL for each milliliter of the resin,flow rate being 20mL/h(equal to 2 column volume),water for impurity eluent being 30 mL(equal to 3 column volume),and the eluent being 60 mL(equal to 6 column volume) of 40% ethanol.Under the above condition,the purity of the total alkaloids was 40.06%,which is 2.56 times as much as the total alkaloids before loading the column.Conclusion This methed is simple and shows good purifying effect.

After the advantages and disadvantages of appointment registration systems in different large hospitals of Beijing were compared, the problems in their appointment registration systems were analyzed and suggestions were put forward for establishing the public appointment registration systems with powerful systematization and compati-bility which are integrated into the EMR system of Beijing.

Lower limb ischemia is common and refractory diseases,in severe cases,it can impact on life quality even threat life.The traditional treatment contain medical and surgical,but cannot obtain satisfactory results.And therapeutic angiogenesis has achieve satisfactory results in animal experimnents and clinical study as its put forward.In recent years,Cell Therapy as one of the research hotspot,the micle aims to introduce the research of progress about therapeutic angiogenesis in detail.

The use of electronic medical records in Beijing hospitals was investigated and some feasible suggestions were put forward for the sharing of electronic medical records according to the problems in their use in order to pro-mote medical information sharing in Beijing hospitals.

Objective:To evaluate the efficacy of acarbose combined with metformin in the treatment of type 2 diabetes with hyper-lipidemia. Methods:A retrospective study was adopted. A total of 2000 patients with type 2 diabetes and hyperlipidemia from general practice in the center were enrolled, and among them, 1050 patients were treated with acarbose, and the other 950 ones were treated with acarbose combined with metformin. After 3-month treatment, the therapeutic effect and adverse drug reactions were compared be-tween the groups. The changes of blood glucose and blood lipid were observed before and after the treatment. Results:The total effec-tive rate was 94. 83% in the combined group, which was significantly higher than that in the control group (72. 38%, P<0. 05). Af-ter the treatment, the blood glucose levels of both groups significantly decreased (P<0. 05), and the decrease in the combined group was more significant than that in the control group (P<0. 05). After the treatment, the serum lipid levels of both groups were signifi-cantly improved (P<0. 05), and the improvement in the combined group was much better than that in the control group (P<0. 05). There was no statistically significant difference in the incidence of drug reactions between the groups (P>0. 05). Conclusion:Acar-bose combined with metformin in the treatment of type 2 diabetes with hyperlipidemia can significantly improve blood glucose levels and blood lipid levels, and the clinical efficacy should be affirmed.

OBJECTIVE:To explore the distribution and drug resistance of pathogens in patients with hospital-acquired pneumo-nia(HAP)from neurosurgery department of the First Affiliated Hospital of Xinjiang Medical University(called“our hospital”for short),so as to provide reference for clinical use of antibiotics in the clinic. METHODS:The pathogen culture and drug sensitivity test of 652 HAP patients were analyzed retrospectively in neurosurgery department of our hospital during May 2011 to May 2015. RESULTS:Of 652 cases,pathogens were detected in 608 cases,with positive rate of 93.3%. Among 608 strains of pathogen, there were 443 strains of Gram-negative bacteria(71.2%)as Klebsiella pneumonia,Pseudomonas aeruginosa and Escherichia co-li;108 strains of Gram-positive bacteria (17.8%) as Staphylococcus aureus and Streptococcus pneumoniae;67 strains of fungus (11.0%)as Candida albicans. There were 67 strains of ESBLs K. pneumonia,43 strains of ESBLs E. coli and 8 strains of methicil-lin-resistant coagulase negative Staphylococci. The drugs sensitive to Gram-negative bacteria included imipenem,piperacillin sodi-um and tazobactam sodium,cefepime,etc.;those sensitive to Gram-positive bacteria included vancomycin,etc. CONCLUSIONS:Main pathogen of HAP patients in neurosurgery department of our hospital are Gram-negative bacteria,and they were highly resis-tant to antibiotics;the highly sensitive drugs to HAP include imipenem and vancomycin,etc.;the antibiotics should be used ratio-nally according to etiological analysis.

Objective To explore the influence of epithelial mesenchymal transition(EMT)in radiosensi-tivity of EGFR-mutant NSCLC cell with acquired resistance to EGFR-TKI. Methods In this study,EGFR-mutant human lung adenocarcinoma cell line PC-9 and Gefitinib acquired resistance cell line PC-9/AB were used. Western blot was used to assess EMT. Wound healing migration assay was tested. CCK8,colony formation and flow cytome-try were used to evaluate survival fraction ,as the sensitivity to irradiation. Results PC-9/AB displayed radioresis-tance(P<0.05). When EMT was reversed with CDH1,its radiosensitivity was significantly higher than PC-9/AB (P < 0.05). PC-9/TGF also displayed radioresistance (P < 0.05),as well as EMT phenotype presented. Conclusion EMT enhanced the radioresistance of EGFR-mutant NSCLC cell with acquired resistance to EGFR-TKI, possibly through TGF-βpathway.