1.Ideas of TCM in treating viral myocarditis with arrhythmia
International Journal of Traditional Chinese Medicine 2011;33(6):527-529
Viral myocarditis involving the cardiac conduction system is easily associated with a variety of arrhythmias. Negative inotropic effect and the potentially induced arrhythmia of antiarrhythmic drugs limit their application. Non-drug treatment with the body injuries and high medical costs holds patients back and leads them to take a conservative treatment. Traditional medical treatment of this disease has a long history and rich experience. Clinical and experimental studies show that traditional Chinese medicine is effective and has few side effects. This article discusses the ideas of treatments of arrhythmia, from three aspects of differentiating diseases and syndrome type, dispelling wind-evil and dredging collaterals and using results of pharmacological researches reasonably.
2.Analysis on Study Hotspots of Clinical Pathway in China
Hao ZHANG ; Shichao XIN ; Fan LI
Journal of Medical Informatics 2017;38(2):57-61
Taking three Chinese databases (CNKI,WANFANG and VIP) as data sources,the paper retrieves documents about Clinical Pathway (CP) dated from 2000 to 2009 and dated from 2010 to 2015 as well as respectively performing the clustering analysis and strategic coordinate analysis of high-frequency keywords on dereplicated document set,summarizes the study hotspots of documents about CP in China.
3.Research on Treatment of Myocardial Fibrosis in Hypertension with Traditional Chinese Medicine
Shichao LYU ; Xiyan YANG ; Junping ZHANG
World Science and Technology-Modernization of Traditional Chinese Medicine 2015;(6):1295-1299
Myocardial fibrosis is the pathological basis of hypertensive heart disease, which is the key to control cardiovascular complications. Traditional Chinese medicine (TCM) has the advantage of targeting many components of a system and providing more integrated regulation than modern medicine. While, modern medicine tends to target a single pathological link. This study was aimed to investigate effects and mechanisms in the treatment of myocardial fibrosis in hypertension with TCM from a different perspective, which provided references for clinical treatment.
4.Hygienic Evaluation of Drinking Water Safety Project in Countryside of Ya'an in 2008
Shichao ZHANG ; Gaoyan WU ; Zhizhi ZHENG
Journal of Environment and Health 1992;0(04):-
Objective To know the basic hygienic condition of the drinking water safety project in the countryside of Ya'an. Methods The water samples were collected in 2008 and were analyzed complying with the standard protocol of drinking water quality test(GB/T 5750-2006),the basic condition of the water supply was investigated in the same time. Results The main water sources of the researched 133 water supply projects were brook and spring,accounted for 64.66%. The central water supply projects with complete water treatment accounted for 36.84% ,the projects with partial water treatment accounted for 56.39% ,the projects without water treatment accounted for 6.77%. In the projects with partial water treatment, 84% of them had no disinfection facilities. In low flow and ample flow period,the eligible rates of water quality were 26.32%(70/266)and 37.98%(98/258)respectively. The bacteriological indexes were the main influencing factors. Conclusion The centralized water supply projects in the countryside in Ya'an have a high eligible rate in the items,but the bacteria contamination is still a main influencing factor in the rural area drinking water safety.
6.Personal characteristics of paradoxical insomnia: A case-control study
Jingping LIAO ; Shichao ZHU ; Qi ZHANG ; Dingxi WANG ; Xiaolin LI
Journal of Central South University(Medical Sciences) 2017;42(8):958-965
Objective:To compare the personal characteristics between the patients with paradoxical insomnia and the patients with primary insomnia or the normal sleepers.Methods:A case-control study with the proportion at 1∶1∶1 was carried out.The patients with paradoxical insomnia were diagnosed in Sleep Medicine Center of West China Hospital of Sichuan University between March 2013 and December 2013.A case of paradoxical insomnia was matched with two controls:a primary insomnia patient and a normal sleeper.A total of 63 matched cases were collected.A face-to-face survey was conducted by using the following scales:General Data Scale and Eysenck Personality Questionnaire (EPQ).Results:The average scores of psychoticism,extraversion,and neuroticism for paradoxical insomnia cases were (52.1±10.2),(49.6±9.8),and (56.0±12.0),respectively.In general,31.7% of paradoxical insomnia patients had psychoticism or psychoticism tendency in their personality,which were more obvious than those in primary insomnia patients (7.9%) (x2=l 1.228,p<0.0125) and normal sleepers (0) (X2=23.774,P<0.0125).Moreover,19.0% of paradoxical insomnia patients had extroversion or extroversion tendency in their personality,which were more significant than those in primary insomnia patients (3.2%) (Z=-4.047,P<0.0125) but less obvious than those in normal sleepers (60.3%) (Z=-4.754,P<0.0125).Also,46.0% of paradoxical insomnia patients had neuroticism or neuroticism tendency in their personality,which were more significant than those in normal sleepers (0) (x2=37.670,P<0.0125) but similar to those in primary insomnia patients (52.4%) (x2=0.508,P>0.0125).Conclusion:The personal characteristics for paradoxical insomnia patients did not reached obviously abnormal level.However,their psychoticism tendency,extroversion tendency and neuroticism tendency needed to be paid attention.
7.Expressions of Slug, BRAF V600E and STIP1 proteins and their correlation with capsular invasion and regional lymph node metastasis in papillary thyroid carcinoma
Xuedong ZHANG ; Shichao CHEN ; De JIAO ; Wenjuan WEN
Cancer Research and Clinic 2017;29(2):104-107,111
Objective To observe the expressions of Slug, BRAF V600E and STIP1 proteins in papillary thyroid carcinoma (PTC), and to explore their correlation with capsular invasion and regional lymph node metastasis. Methods Slug, BRAF V600E and STIP1 expressions in 107 cases of differentiated PTC were examined by immunohistochemical staining. The expressions of three proteins and clinicopathological data were statistically analyzed. Results Positive rates of Slug, BRAF V600E and STIP1 in PTC were 65.4 % (70/107), 61.7 % (66/107) and 66.4 % (71/107), respectively, and overexpression of Slug, BRAF V600E and STIP1 was significantly associated with capsular invasion and regional lymph node metastasis in PTC (P< 0.05). There are a significant correlation between expression of Slug and BRAF V600E in PTC (r= 0.235, P< 0.05). Conclusion Overexpression of Slug, BRAF V600E and STIP1 proteins is associated with capsular invasion and regional lymph node metastasis in PTC, which maybe useful for predicting regional lymph node metastasis and prognostic evaluation.
8.Value of fine needle aspiration biopsies in the diagnosis of medullary thyroid carcinoma:Analysis of 17 cases
Xuedong ZHANG ; Shichao CHEN ; Ying DU ; Yubo REN
Chinese Journal of Endocrinology and Metabolism 2016;32(8):677-679
[Summary] The cytomorphological features of 17 cases of confirmed MTC were analyzed. cytomorphological features were moderate to marked cellularity, isolated cells alternate with clusters in variable proportions, plasmacytoid, polygonal, round, and(or) spindle-shaped cells, mild to moderate pleomorphism, finely or salt and pepper-like chromatin, frequent binucleation/ multinuleation, rare bizarre giant cells may be seen, nuclear pseudoinclusions are occasionally noted, unremarkable nucleoli, cytoplasm is granular and variable. Amyloid is often present. MTC could be adequately diagnosed by FNA, According to the clinical characteristics and cellblock immunochemical staining can be helpful in diagnosis of MTC.
9.Clinical features of gout in female residents in coastal regions of Shandong province
Wenwen YANG ; Shichao XING ; Xiaoyu CHENG ; Lingling CUI ; Xiaokun ZHANG ; Changgui LI
Chinese Journal of Endocrinology and Metabolism 2011;27(11):925-927
The clinical features of 172 female and 1 067 male residents with gout in the coastal regions of Shandong province were analyzed.The results showed that as compared with male patients the onset of gout occurred at an older age in the female patients,and there were less obesity and tophi as well as less alcohol consumption and medication needed in the female patients.However,comorbidity with diabetes mellitus and coronary heart disease,as well as involvement of upper limb and other metatarsophalangeal joints were more prevalent in the female patients.
10.Vitamin C treatment promotes cell proliferation of human adipose-derived stem cells under high glucose conditions
Jiangfeng LI ; Shichao DING ; Yawei QI ; Jin LI ; Guofang ZENG ; Qiao LAI ; Li LIU ; Peihua ZHANG
Chinese Journal of Tissue Engineering Research 2017;21(13):1992-1997
BACKGROUND:Although vitamin C has an anti-oxidation role and can promote cell proliferation, there is a lack of research about the promoting effect of vitamin C on the proliferation of adipose-derived stem cells under high glucose conditions and the related molecular mechanisms.OBJECTIVE:To explore the promoting effect of vitamin C on the proliferation adipose-derived stem cells treated by the high glucose and the related molecular mechanisms.METHODS:Passage 3 human adipose-derived stem cells were cultured under high glucose conditions and then treated with different concentrations of vitamin C (0, 100, 150, 200, 250, 300 μmol/L). Cells cultured under low glucose conditions acted as controls. The expression levels of p-ERK and p-AKT proteins were detected by western blot. MTT method was used to choose the optimal concentration and time of vitamin C for all the subsequent tests. Human adipose-derived stem cells cultured under high glucose conditions were divided into four groups, and cells in blank control group had no treatment. Cells in the other three groups were treated with the optimal concentration of vitamin C (vitamin C group), LY294002+the optimal concentration of vitamin C (LY294002 group), or U0126+the optimal concentration of vitamin C (U0126 group) for 48 hours.EdU staining assay was used to detect the cell proliferation of human adipose-derived stem cells.RESULTS AND CONCLUSION:(1) Cell counting kit detection:We found that high glucose reduced the proliferation of human adipose-derived stem cells, and vitamin C promoted the proliferation of these cells. The best concentration of vitamin C was 200 μmol/L and the optimal effect time was 48 hours. (2) Western blot detection:Compared with the 0 μmol/L vitamin C group, the level of p-ERK in the 200 μmol/L vitamin C group was upregulated significantly (P < 0.01),while no significant expression change in p-AKT protein was found in control, 0 and 200 μmol/L vitamin C groups.(3) EdU test:the number of EdU positive cells was significantly higher in the vitamin C, LY294002, and control groups compared with the blank control group (P < 0.01). Moreover, compared with the vitamin C group, the EdU positive cells in the U0126 group were decreased significantly in number (P < 0.01). In conclusion, the ERK/MAPK signaling pathway is involved in the promotion effect of vitamin C on the proliferation of human adipose-derived stem cells under high glucose conditions.