Abscopal effect is for tumor therapy and control of tumor metastasis.it will produce consider-able eignifieance in clinical tumor therapy.The exactly mechanisms of this effect have not been recognized com-pletely so far,and researchers find this effect is associatod with immune system response,espeeiaHy the cell-me-diated immunity.The response of abscopal effect can activate antitumor immunologic response in vivo possibly through antigen releasing and presentation,activation of T cell and natural killer cell,the role of cytokine,in-flammatory reaction,apoptosis,and etc.

The first-line chemotherapy with platinum-based regimens for 4 to 6 cycles is a standard care in advanced non-small cell lung cancer (NSCLC). However, for patients who got disease stabilization or maximal response after first line chemotherapy, how to choose safe and efficacy anticancer agents to extend first-line treatment and provide a better clinical benefit is deserving of more concerns currently. In this article,the clinical progress of the chemotherapy and molecular targeted agents as maintenance therapy for patients with advanced NSCLC is reviewed.

Atrioventricular septal defect (AVSD)is a frequently diagnosed congenital heart malformation affecting the atrioventricular valves and septa. Heart transcription factors play fundamental roles in atrioventricular valves development and atrioventricular septa formation. Now cardiac transcription factors ( GATA4, NKX2. 5,TBX5 ,ZIC3)have been identified to involve in the pathogenesis of AVSD in humans. Their abnormal expression or function change may cause atrioventricular valve and septa developmental anomalies. Here we review advances in the understanding of the relationship between these transcription factors and AVSD.

By analyzing the current situation of TCM science popularization, We found that internet is serving as the most influential and rapid developing media at present. Therefore, a through excavation and utilization of internet as a tool for TCM science popularization will not only expand TCM science popularization platform, enhance mass foundation, promote mass understanding and recognition of TCM, but also meet the need of TCM self-development.

Object A method for the determination of daidzein, genistein, daidzin and genistin in soybean extract by RP HPLC was established Methods Zorbax SB C 18 column (4 6?15 mm, 5 ?m) was used Daidzein and genistein were separated with mobile phase Ⅰ∶methanol acetonitrile 0 1% phosphoric acid solution (30∶8∶62) Daidzin and genistin were separated with mobile phase Ⅱ∶methanol acetonitrie 0 1% phosphoric acid solution (16∶24∶60) The UV detection wavelength was 254 nm Results The average recoveries of daidzein, genistein, daidzin and genistin were 98 7%, 99 5%, 98 4%, 98 6% and the precision (RSD) were 1 4%, 0 9%, 0 9%, 1 7% (n=4) respectively Conclusion: The method was accurate, rapid and with good reproducibility

Objective:To investigate the distribution and regulation of uterine NK cells in mouse uterus during early pregnancy. Methods:Using a unique uNK cell marker,Dolichos biflorus agglutinin (DBA) lectin,to localize NK cells in uterus of normal pregnancy,delayed implantation and artificially induced decidualization. Results:DBA staining is mainly distributed in some vascular endothelial cells during embryo pre-implantation. In D5 of pregnancy after embryo implantation,NK cells were distributed in the stroma of uterine mesometrial pole,with round,immature and small lymphocyte-like cells. During D7 and D8 of pregnancy,the immunostaining results showed that uNK cells were increasingly accumulated in the mesometrial pole of implantation sites,with their morphology changing from small round cells with scattered cytoplasm to large and mature cells with heavy cytoplasmic granules. In the artificially induced decidualization model,the distribution and maturity of NK cells are similar to those of the normal pregnancy in the mouse uteri. Conclusion:The distribution and maturation of uterine NK cells are dependent of uterine decidualization in mouse early pregnancy.

Objective To investigate the clinical efficiency and immune adjustment of oxymatrine capsule and acitretin in the treatment of psoriasis.Methods Eighty patients with psoriasis were randomly divided into treatment (T) and control (C) groups.The T group took orally oxymatrine one capsule (0.2g) three times a day and one acitretin (10 g) two times a day.The C group only took orally one acitretin (10 g) two times a day.The T and C groups were applied the same drug for external use.Moreover,another 40 normal volunteers were set as normal control group.The peripheral blood T cell subset CD3 +,CD4 +,CD8 +,CD4 +/CD8 + were detected in all the three groups (T,C,and normal) before and after treatment.Results The effective rate was 92.5％ in the T group,and 72.5％ in the C group with statistical significance (x2 =8.66,P ＜ 0.05).The symptom integral decline index of two groups before and after treatment has statistical significance (t =10.02,P ＜ 0.05).For the peripheral T cell subset CD3 +,CD4+,CD8 +,CD4 +/CD8 + in the T group,a significant difference was found between pretreatment and posttreatment [(57.13 ±8.14)％,(37.62 ±7.97)％,(33.01 ±2.97)％,(1.24 ±0.51)％ vs (60.09 ±11.53)％,(43.02±7.67)％,(25.63 ±4.24)％,(1.73 ±0.69)％,t =3.08 ～9.02,P ＜0.01].However,there was not any statistical significance between pretreatment and posttreatment in the C group (P ＞ 0.05).Conclusions The treatment of common psoriasis combined with oxymatrine capsule and acitretin had a good curative effect and it improved the imbalance of peripheral blood T cell subsets.

Objective To summarize the experience of nursing Moyamoya patients undergoing STA-MTA bypass.Method The histories of nursing 14 Moyamoya patients undergoing STA-MTA bypass were retrospectively analyzed to summarize the nursing experience.Result The outcomes of all the 14 patients were good.TCD or DSA showed all the anastomosed arteries were patent, and cerebral perfusion was improved.Conclusion The nursing strategies including careful observation of patients,prevention of cerebral hemorrhage and ischemia and enhanced function exercises is critical for patients’rehabilitation.

Objective:To explore the relationship between pulse wave velocity(PWV)and blood pressure classification in patients with hypertension in pretherapy and posttherapy.Methods:Totally,183 patients with essential hypertension were recruited in the study and their brachial-ankle PWVs were recorded by an automatic arterial stiffness measurement device.PWVs were compared between patients with varied blood pressures in pretherapy and posttherapy.Results:There was significant diference in PWV between patients with pretherapy and posttherapy[(2 080?26)cm/s vs(1 604?32)cm/s,P