1.Analysis of legal contagious diseases failed to report
Chinese Journal of Disease Control & Prevention 2001;5(1):30-31
Objective To appraise the real situation of lega l contagious diseases exactly, to find and to correct the problems in reportin g epidemic diseases in time. Methods Census and sampling surve y were applied in the different level medical institutions and inhabitants to in vestigate the legal contagious diseases failed to report. Results 13 species of legal contagious diseases were found out in medical institutio ns, amouted to 5 917 cases, and the rate failed to report was 29.85%; there wa s signifi cant difference in different medical institutions; 9 species of legal contagious diseases amouted to 546 cases were found out in 56 947 inhabitants, and its inc idence rate was 505.73 per 100 000, while the rate failed to report was 48.71%. C onclusions We should strengthen the reporting of epidemic disease in ru ral and indiviual medical institutions.
2.Observation on clinical effect of acupuncture for peripheral facial paralysis in acute period and facial nerve F-wave
Journal of Acupuncture and Tuina Science 2015;(6):344-348
Objective:To observe the clinical effect of acupuncture on peripheral facial paralysis in acute period and changes in facial nerve F-wave.
Methods:A total of 148 eligible cases were randomly allocated into an observation group (n=74) and a control group (n=74) by their visiting sequence. In addition to oral Prednisone and Aciclovir tablets, patients in the observation group received point-towards-point acupuncture therapy, whereas patients in the control group received routine acupuncture therapy. The treatment was done once a day and 6 times made up a course of treatment. The efficacy evaluation was made after 2 courses. The electromyography (EMG) F-wave was monitored before and after treatment.
Results:After 2 courses of treatment, the recovery rate and total effective rate were 47.3% and 94.6% respectively in the observation group, versus 20.3% and 82.4% in the control group, showing statistical differences (P<0.01). Before treatment, the facial nerve F-wave latency on the affected side was prolonged and its frequency of occurrence was decreased in both groups. After treatment, the F-wave latency and frequency of occurrence were significantly improved in both groups (P<0.05) and there were significant between-group differences (P<0.05).
Conclusion:In addition to Western medication, point-towards-point acupuncture therapy can obtain more accurate and better effect than routine acupuncture therapy for acute peripheral facial paralysis.
3.Research Progress of Treatment of Prolapsed Lumbar Intervertebral Disc by Acupuncture and Moxibustion
Journal of Acupuncture and Tuina Science 2004;2(5):53-58
This article reviewed information related to the treatment of lumbar intervertebral disc protrusion by acupuncture and moxibustion in recent 10 years, so as to grasp the current situation of this specific topic and provide the reference evidence for the further study. According to the related professional literature of acupuncture and moxibustion, the authors found that acupuncture and moxibustion therapy had definite therapeutic effect on the lumbar intervertebral disc protrusion. But most clinical reports were retrospective and had no uniform therapeutic effect criteria, interfering with the screening of the best therapeutic plan. The authors suggested that the study of action mechanism of acupuncture and moxibustion and the clinical prospective survey should be intensified.
4.Clinical Observation on Acupuncture Combined with Hyperbaric Oxygenation in Treating Patients with Cervical Spondylosis of Nerve Root Type in Acute Phase
Jianxiong WANG ; Junfeng ZHANG
Journal of Acupuncture and Tuina Science 2014;(4):236-240
Objective: To observe the therapeutic efficacy of acupuncture combined with hyperbaric oxygenation for cervical spondylosis of nerve root type in acute phase.
Methods: One hundred cases with cervical spondylosis of nerve root type in acute phase were randomly divided into two groups, with 50 patients in each group. The patients in the treatment group were treated by acupuncture combined with hyperbaric oxygenation, and those in the control group only received the same acupuncture therapy as the treatment group. The therapeutic efficacy was evaluated after 2 courses of treatment.
Results: In the treatment group, 27cases were cured, 9 cases showed markedly effective, and 4 cases were invalid, and the recovery rate was 67.5%, the total effective rate was 90.0%; in the control group, 18 cases were cured, 17 cases showed markedly effective, 15 cases were invalid, and the recovery rate was 36.0%, the total effective rate was 70.0%. There were statistically significant differences between two groupsin the recovery rate and the total effective rate (bothP<0.05). The average cure time of the treatment group was (15.56±7.13) d, and that of the control group was (22.13±7.78) d, which also had significant difference between the two groups (P<0.05).
Conclusion: Acupuncture combined with hyperbaric oxygenationhas rapid and reliable effects for cervical spondylosis of nerve root type in acute phase.
5.Risk factors analysis of infection after total hip replacement and its early diagnosis
Chongqing Medicine 2013;(33):3999-4001
Objective To explore the risk factors analysis of infection after total hip replacement and its early diagnosis .Methods 86 patients with total hip replacement were selected ,the clinical data and surgical process were obtained retrospective ,to analysis the risk factors analysis of infection after total hip replacement .Results The age of infected patients with total hip replacement was significantly higher than non-infected patients (P< 0 .05) .The surgery time and postoperative drainage time in infected patients were significantly longer than non-infected patients(P<0 .05) .The risk of infection of patients who had long-term application of hormone ,complicated with diabetes mellitus ,history of hip surgery and lower serum albumin content were significantly higher (P<0 .05) .Intraoperative blood loss ,sex ,patient bone cement application and antimicrobial drug use had no obvious relation with post-operative infection(P>0 .05) .After the early diagnosis and treatment ,the joints function of infected patients were recovery good , and without serious effects .Conclusion The infection after total hip replacement is associated with a variety of factors ,it should give positive prevention in the clinical work .For suspected patients should be early diagnosis ,and should choose suitable treatment according to the patient′s specific situation .
6.Research progress of application of platelet glycoprotein IIb/IIIa inhibitors in acute coronary syn-drome
Chinese Journal of cardiovascular Rehabilitation Medicine 2015;24(1):88-91
Through occupying binding site of glycoprotein IIb/IIIa receptor,platelet glycoprotein IIb/IIIa inhibitor (GPI)inhibit the combination of fibrinogen and the receptor,then inhibit platelet aggregation.GPI is the most powerful anti-platelet drug and possesses application value in ACS now.This article made an overview on the newest research progress of safety and effectiveness of GPI in ACS.
7.Effects of testosterone on heart function following heart failure after myocardial infarction in rats
Clinical Medicine of China 2014;30(8):820-824
Objective To investigate the effects of low dose testosterone on heart function,and ventricular remodeling in male rats with postinfarction congestive heart failure(CHF).Methods Sixty SD rats were undergone surgery,of which,45 rats were performed coronary artery ligation and other 15 were sham group (PS group).Six weeks later,left ventricular function of survived rats was examined by echocardiography,and LVEF≤45% was defined as the standard of successful CHF model.All survived model rats were randomly divided into 2 groups:TU group(n =16) treated with TU 5 mg/kg per 2 weeks intramuscular injection;placebo (PL) group (n =16) treated with PL.Mter treatment for 12 weeks,left ventricular ejection fraction(LVEF) was assessed by echocardiography again.Serum testosterone level was determined by radioimmunoassay.The expression of tumor necrosis factor-or (TNF-α) mRNA and matrix metalloproteinase (MMP)-9mRNA in myocardial tissue was measured by RT-PCR.Results In male post-myocardial infarction rats,serum testosterone level and LVEF were decreased significantly than PS group(P < 0.05),and the expression of TNF-α mRNA and MMP-9 mRNA in myocardial tissue was increased significantly than PS group (P < 0.05).Mter low dose TU therapy,LVEF of rats in TU group improved significantly(P <0.05),and the expression of TNF-α mRNA and MMP-9 mRNA in myocardial tissue was reduced significantly (P < 0.05).Meanwhile,the mortality was decreased (P < 0.05).Conclusion Low dose testosterone therapy can restore the inflammatory imbalance and suppress the ventricular remodeling in male post-myocardial infarction rats and improve left ventricular function,as well as reduce mortality.
9.Effects of penehyclidine hydrochloride on lipopolysaccharide-induced neonatal cardiomyocyte dam-age and NF-κB activation
Lingjie ZHANG ; Junfeng ZHANG ; Tao WANG
Journal of Clinical Surgery 2014;(8):603-605
Objective To observe the effects of penehyclidine hydrochloride(PHC)on lipopo-lysaccharide-induced neonatal cardiomyocyte damage.Methods After the primary cardiomyocytes culture of neonatal rat on postnatal day 1,the myocytes were randomly divided into 4 groups:the control group,the lipopolysaccharide(LPS)group,the low dosage PHC pretreatment group and high dosage PHC pretreatment group.Activities of myocardial enzymes and cardiac troponin and cell survival rate were measured.Expres-sion of NF-Κb(p65)and IκB-α(NF-κB inhibitor)phosphorylation were assessed using Western blot.Re-sults Compared with the control group,activities of myocardial enzymes and cardiac troponin in the LPS group were elevated but the survival rate were down-regulated.All these effects were reversed in the PHC pretreatment group.Results of Western blot showed that phosphorylation of IκB-αand p65 expression were up-regulated in the LPS group.In the PHC pretreatment group,phosphorylation of IκB-αand p65 expres-sion were down-regulated.Conclusion Penehyclidine hydrochloride can inhibit lipopolysaccharide-in-duced neonatal cardiomyocyte damage and the down-regulation of NF-κB activity might be involved.