1.Data Quality Control of Regional Population Health Information Platform
Journal of Medical Informatics 2017;38(4):67-70
The paper analyzes the problems of data quality of the population health information platform and the causes,constructs the data quality control and evaluation system from the aspects of evaluation model,data quality evaluation,process tracking and feedback,provides guarantee for improving data quality of the platform,and thus lays a solid foundation for sharing and application of big data of health care.
2.THE SEGMENTAL DISTRIBUTION OF SENSORY AND MOTOR NEURONS IN RABBIT NEIGUAN (内关, P6) ACUPOINT AREAS—A HORSERADISH PEROXIDASE (HRP) METHOD STUDY
Zhangjin ZHANG ; Guoming WANG ;
Journal of Xi'an Jiaotong University(Medical Sciences) 1981;0(03):-
The segmental distribution of sensory and motor neurons in Neiguan (内关P6) acupoint areas was studied respectively in 8 rabbits with a horseradish peroxidase (HRP) method. The labeled neurons were found in C5-T1 segments of the spinal ganglia and in C7-T1 segments of the spinal cords (injected sides). Most labeled neurons were found concentrated in C8 and T1 of the spinal ganglia, and principally located in the circumferental areas of the spinal ganglia (47.27%). In spinal cord, the labeled neurons were located in the lateral areas of the ventral horns and the juncture of it and the lateral horns (Ⅷ-Ⅸlayers). In addition, the relation of the relative specifity of acupoints to the distributional segments of the neurons and its concentration was discussed.
3.Study pediatric fundus imaging techniques to improve the diagnosis of retinal diseases in children
Chinese Journal of Ocular Fundus Diseases 2016;32(3):237-242
Fundus photograph,angiography,optical coherence tomography,ultrasonography and other image technology and visual electrophysiology can provide a wealth of information for the diagnosis and treatment of pediatric retinal diseases.However,it put forward higher requirements on pediatric retinal imaging equipment and techniques which will be quite different from adult,because of pediatric retinal disease has its own characteristics,such as disease spectrum,pathogenesis,and pathophysiology.The principles and methods of image results interpretation on adult were not quite ready for children.It is necessary to further study the fundus imaging techniques suitable for children,gradually establish standardized examination procedures and clinical interpretation system,to promote the diagnosis of retinopathy in children.
4.AGING CHANGES IN TYROSINE HYDROXYLASE IMMUNOREATIVE NEURONS IN THE LOCUS COERULEUS OF THE RAT
Guoming WANG ; Keren ZHANG ; Zhangjin ZHANG
Journal of Xi'an Jiaotong University(Medical Sciences) 1982;0(04):-
Aging changes of tyrosine hydroxylase (TH) -immuno reactive neurons in the locus coeruleus were examined in young (3 month-old). adult(12 month-old) and aged(20 month-old) Wistar male rats, using the IGSS method and image quantitative analysis. The results obtained are as follows: ① The number of TH-immunoreactive neurons docreased markedly (P
5.Diagnostic Value of MicroRNA-499 for Acute Myocardial Infarction:a Meta-Analysis
Gaoming ZHANG ; Guoming ZHANG ; Yongjie XIA
Journal of Modern Laboratory Medicine 2016;(1):86-88
Objective To evaluate the diagnostic value of microRNA-499 (miR-499)levels in acute myocardial infarction (AMI)diagnosis.Methods Retrieve Articles,Wanfang,China Knowledge Network,NCBI PubmMed,EMBSASE database 2010~2015 years met the inclusion criteria published abroad in relation to miR-499 diagnosis ten cases of human AMI litera-ture.The quality of the sudies was evaluated by QUADAS tools through a comprehensive analysis of the random effects model effect size,the use of meta-disc 1.4 software for statistical analysis software.Results Ten studies met the included criteria.The summary estimates for miR-499 diagnosis of MI sensitivity was 83% (95% CI,0.81 ~ 0.85),specificity of 81% (95% CI,0.78~0.83),positive predictive value of 4.53 (95% CI,3.12~ 6.58),negative predictive value was 0.22 (95% CI,0.14~0.33),diagnostic odds ratio 22.73 (95% CI,10.78~47.93).The area under the curve (AUC)for miR-499 was 0.90 with Q value of 0.84.Conclusion MiR-499 has high diagnostic value for acute myocardial infarction.
6.Research progress on cancer stem cells in ocular malignancy
Lei ZHENG ; Jiamin WEN ; Guoming ZHANG
Recent Advances in Ophthalmology 2017;37(7):692-696
Cancer stem cells (CSCs) are a small subset of cancer cells in the tumor,which possess the exclusive ability to proliferate indefmitely and multiple differentiation.These tumor cells play a crucial role in the maintenance of malignant proliferation,drug resistance,metastasis and recurrence.Majority of ocular malignancies have the properties of high recurrence,metastasis and poor prognosis.Recently,CSCs was found to exist in the ocular malignancies,also might be involved in the tumor initiation and progression.This article reviews the research progress on CSCs in ocular malignancy.
7.Disease Diagnosis Based on Deep Learning
Jiafa LU ; Guoming ZHANG ; Anqi CHEN
Journal of Medical Informatics 2017;38(4):39-43
The paper takes heart disease dataset of UCI as experimental data,carries out disease diagnosis and calssification based on the deep learning technology of machine learning,compares with Random Forest (RF),Support Vector Machine (SVM) and Neural Network (NN) classification,and indicates that the Deep Learning (DL) technology is of great potential and important value for exploration of medical big data.
8.The comparison of multifocal electroretinogram before and after retinal detachment surgery
Guoming ZHANG ; Dezheng WU ; Rulong GAO
Chinese Journal of Ocular Fundus Diseases 2000;0(04):-
Objective To explore the changes of multifocal electroretinogram (mERG) before and after retinal detachment surgery and its clinical significance. Methods Eighteen patients suffered from rhegmatogenous retinal detachment underwent mERG before and after surgery using VERIS Science TM 4.0. The mERG at different area was compared between preoperative and postoperative surgery. Results Preoperatively, the latencies of a wave and b wave in detached area were statistically longer than in attached area ( t =4.541 and 6.784, P
9.Comparison of Monoclonal Antibody J28 and Peanutagglutinin Immunoblotting for Detecting Fetoacinar Pancreatic Protein
Wenjun ZHANG ; Guoming XU ; Zhiqun ZHOU ; Hongju ZHANG
Academic Journal of Second Military Medical University 1982;0(02):-
We used SDS-polyacrylamide gel electrophoresis (SDS-PAGE), immunoblotting of monoclonal antibody (McAb) J28 and peanutagglutinin (PNA) for detecting fetoacinar pancreatic protein (FAP) in extracts of 20 cases of fetal pancreas, 5 of pancreatic cancer and 4 of normal pancreas. The result showed that fetal pancreas and pancreatic cancer had a same level band about 110000 in Commassie blue stain, but absent in normal pancreas. The band could react with both McAb J28 and PNA PNA also could react with smaller glycoprotein in pencreatic cancer. It is suggested that McAb J28 and PNA combine with different sites of FAP.
10.The clinical evaluation of ulinastatin on improvement of renal syndrome hemorrhagic fever with small vas-cular injury
Yuejun PAN ; Yuan ZHANG ; Guangying WEI ; Guoming. ZHANG
The Journal of Practical Medicine 2017;33(12):2025-2028
Objective To explore the clinical effect of ulinastatin on capillary injury improvement of renal syndrome hemorrhagic fever and renal leakage. Methods Patients were divided into 2 groups according to the random number table. The experimental group(25 cases)was given with ulinastatin and the control group(25 cases) was given 5% sugar solution as a blank control. All patients were treated with nutritional support ,rehydration , prevention of bleeding and other symptoms. In addition,according to the number of days of fever in the experimental group,the patients were divided into two groups. The experimental group A(9 cases)had fever 1 ~ 4 days;the experimental group B(16 cases)had fever 5 ~ 7 days. All patients were measured in microalbuminuria ,serum creatinine,plasma albumin and other clinical indicators after 7 day treatment. Results Compared with the control group,microalbuminuria of the experimental group was significantly decreased;Creatinine recovery rate was faster than that in the control group;Plasma albumin had significantly increased;The number of symptomatic days of concurrent perfusion of other tissues had also significantly reduced. Compared with the experimental group B , microalbuminuria of the experimental group A was significantly decreased;Creatinine recovery rate was faster than that in the experimental group B;Plasma albumin had significantly increased;The number of symptomatic days of concurrent perfusion of other tissues was also significantly reduced. Conclusion Ulinastatin could effectively treat vascular injury and syndrome due to capillary leakage caused by epidemic hemorrhagic fever virus ,and the best effect occurs in early application in the fever.