5.Analysis of the difference on the effect of atropine sulphate and cyclopentolate hydrochloride in the treatment of youth hyperopia cycloplegic refraction
Chinese Journal of Postgraduates of Medicine 2012;(33):15-17
Objective To compare the effect of atropine sulphate and cyclopentolate hydrochloride in the treatment of youth hyperopia cycloplegic refraction,and provide the basis for a reasonable choice of the youth cycloplegic refraction drugs.Methods Ninety hyperopia children met inclusion criteria with refractive errors (180 eyes) were subjected to cycloplegic refratometry by 1% cyclopentolate hydrochloride followed with 1% atropine sulphate eye used gel.The refractive results,pupil size,residual adjustment amount and systemic side reactions were measured and compared by TOPCON.Results The coincidence rate of spherical lens degrees,cylinder lens degrees and axis of astigmatism degrees respectively was 84.44% (152/180),92.78% (167/180) and 92.78% (167/180) between atropine sulphate and cyclopentolate hydrochloride.The spherical lens degrees of cyclopentolate hydrochloride was lower than atropine sulphate,the difference was statistically significant (P <0.01),the cylinder lens degrees and axis of astigmatism degrees had no significant difference between two drugs (P> 0.05).The pupil size and residual adjustment amount of cyclopentolate hydrochloride had no significant difference with atropine sulphate (P > 0.05).The incidence of adverse reactions of cyclopentolate hydrochloride was 3.33% (3/90),atropine sulphate was 13.33% (12/90),the cyclopentolate hydrochloride was significantly lower than atropine sulphate (P < 0.05).Conclusion The cyclopentolate hydrochloride has powerful,fast and secure feature in the treatment of youth hyperopia cycloplegic refraction,has good ciliary muscle paralysis effect,has longer paralysis time,as effective as the atropine sulphate,and has a shorter recovery time and better security,is ideal cycloplegic drugs for youth hyperopia cycloplegic refraction.
6.One special malfunction of Aucson 128xp colorful Ultrasound Diagnostic Equipment
China Medical Equipment 2009;(8):49-50
We here introduced in detail one special malfunction of Aucson 128xp colorful Ultrasound Diagnostic Equipment as a reference for the same trade or occupation.
7.Relationship of tranexamic acid therapy duration with hidden blood loss after total hip arthroplasty
Chinese Journal of Trauma 2013;(6):541-544
Objective To assess the impact of tranexamic acid on visible and hidden blood loss after the preliminary unilateral total hip arthtoplasty (THA).Methods The study involved 60 patients who received primary unilateral THA due to femoral neck fracture from March 2010 to September 2011.They were 18 males and 42 females,at 58 to 86 years of age (average 74.5 years).They were divided into Group A (n =20),not given tranexamic acid,Group B (n =20),given tranexamic acid in operation,Group C (n =20),given tranexamic acid at preoperative one hour according to stratified random method.Total red blood cell loss,visible red blood cell loss,and hidden red blood cell loss in each group were calculated.Results Visible red blood cell loss in Groups A,B,and C was (95.4 ± 17.7) ml,(45.5 ± 11.5) rnl,and (45.3 ± 8.4) ml respectively.Moreover,difference of visible red blood cell loss was significant between Groups A and B (P < 0.05),but insignificant between Groups B and C (P > 0.05).Hidden red blood cell loss in Groups A,B,and C was (322.4 ± 57.7) ml,(203.8 ±46.6) ml,and (137.6 ± 34.7) ml respectively,with significant difference between Groups A and B (P<0.05) and between Groups B and C (P<0.05).Conclusions Tranexamic acid reduces the visible and hidden blood loss in primary unilateral THA significantly.While tranexamic acid administered at preoperative one hour gains advantage of less hidden blood loss over the intraoperative administration.
8.Teaching reform on laboratory diagnostics for eight-year-program clinical medicine majors at undergraduate level
Chinese Journal of Medical Education Research 2013;(5):487-489
Supported by Center of Laboratory Medicine of PLA,the Third Military Medical University launched teaching reform on laboratory diagnostics by integrating and optimizing teaching contents,adopting case centered teaching method,introducing thinking modes of evidence-based laboratory medicine and strengthening bilingual teaching.Abilities of students to determine the clinical stage and to evaluate the effect of treatment as well as prognosis of diseases were promoted.
9.The role of intraoperatve radiotherapy in the management of breast cancer
China Oncology 2013;(8):590-595
Breast cancer is the most common disease in women worldwide, which not only threatened the women’s survival time, but also inlfuenced their quality of life as well. Within this challenge, it’s important to optimize the current multidisciplinary treatment stratagem for breast cancer. Radiotherapy is one of the most important treatment modality for patients with breast cancer, with the trend to shrink the irradiated volume and shorten the total fraction times in recent years. Intraoperative radiation therapy (IORT) as a fast and convenient procedure has the ability to deliver a high, single-fraction radiation dose to tumor beds with minimal exposure of surrounding tissues (lung, heart, etc.), which could be displaced or shielded right after the tumor removal during the surgical procedure. Right now, IORT has been either integrated as a boost technique in multimodal approaches using postoperative EBRT in the treatment of early breast cancer patients undergoing breast conservation surgery or used as a single dose accelerated partial breast irradiation technique for these patients. This review discussed the rationale of IORT, the beneifts and limitations of IORT, the indication and the clinical results of this procedure, including treatment related side-effects as well in order to provide the preliminary evidence based approach for early breast cancer patients.
10.Multidrug resistance-associated proteins and their roles in multidrug resistance.
Acta Pharmaceutica Sinica 2011;46(5):479-86
Multidrug resistance (MDR) is a major impediment to the success of cancer chemotherapy. Multidrug resistance-associated proteins (MRPs) play an important role in the process of MDR. As an ATP-binding cassette (ABC) transporter superfamily, MRPs are selective and specific drug efflux pumps. In this paper, physiological characteristics, structural characteristics and resistance profile of MRPs and the associated reversal studies are reviewed.