OBJECTIVETo investigate the chemical constituents of Chinese herb Melastoma dodecandrum.

METHODThe chemical constituents were isolated by solvent extraction and chromatography. Their structure were identified on the basis of physic-chemical constants and specral data.

RESULTFive compounds were isolated and identified as hexacosanoic acid (I), quercetin(II), avicularin(III), gallic acid (IV), kaempferol(V).

CONCLUSIONThe above-mentioned compounds were separated from the plant for the first time.

Fatty Acids ; chemistry ; isolation & purification ; Flavonoids ; chemistry ; isolation & purification ; Gallic Acid ; chemistry ; isolation & purification ; Kaempferols ; chemistry ; isolation & purification ; Melastomataceae ; chemistry ; Plants, Medicinal ; chemistry ; Quercetin ; chemistry ; isolation & purification

This study aimed to investigate the clinical efficacy of pulsed radiofrequency (PRF) of the dorsal root ganglion (DRG) with pain management as treatment of post-herpetic neuralgia (PHN). A total of 78 patients with PHN in the thoracolumbar region were randomly divided into two groups (n = 39 for each group): Group A, oral drug treatment only; Group B, DRG PRF of the thoracic spinal nerve combined with oral drug treatment. The numerical rating scale (NRS) scores of both groups were observed before treatment and at 1, 4, 8, and 12 weeks after treatment. The results showed that the NRS scores of both groups were significantly decreased after treatment (P < 0.05). In addition, the NRS score in Group B decreased significantly more than in Group A (P < 0.05). In conclusion, DRG PRF with pain management is a safe and effective treatment for elderly PHN patients, and it can quickly alleviate pain symptoms.