Objective:To screen neuroses in medical students and explore related factors.Method:Totally 1677 college students were screened by Neuroses Screener,who was positive(scored 2 or more)was investigated with Questionnaire on History of Neuroses and interviewed by psychiatrist.Psychiatric diagnosis was made if necessary according to CCMD-2-R.EPQ,EMBU and Quality of Life Scale were applied to all subjects.Multi-factor analysis was made.Results:Negative life events,unhealthy parentai education and neuroticism in EPQ were main factors influencing the incidence of neurosis.EPQ-E and warmth from parents had protective effect on occurrence of neurosis.Conclusion:Neuroticism is the basis of neurosis,unhealthy parental education and negative life events precipitate the occurrence of neurosis.Exorcism and warmth of parents have protective effect.

Objective To understand the relationship between spouses' marital quality and their mental health.Method 384 pairs of couples from 28 provinces in China were examined with the Marriage Perception Scale(MPS) and Symptom Checklist 90 (SCL-90).Result ( 1 ) Husbands' scores of couple conflict( 10.85 ±5.02) were significantly lower than wives' scores of couple conflict ( 11.66 ± 5.63 ) (P ＜ 0.05 ).( 2 ) Husbands' seores in the 5 factors of SCL-90 ( symptoms that somatization ( 1.44 ± 0.50 ), interpersonal sensitivity ( 1.57 ±0.54),depression( 1 .50 ± 0.52 ) ,anxiety ( 1.46 ± 0.54 ), panic ( 1.38 ± 0.55 ) ) were significantly higher than wives' in the 5 factors of SCL-90[symptoms that somatization ( 1.52 ± 0.54 ), interpersonal sensitivity ( 1.66 ±0.58), depression (1.59 ±0.59 ), anxiety ( 1.55 ± 0.58 ), panic ( 1.47 ± 0.59 )] (P ＜ 0.05 ).( 3 ) Individual's MPS and its SCL-90,spouses' MPS andits SCL-90 correlated as well( r=-0.372 ～0.239)(P＜0.01 ).Conclusion Couples are similar in their marriage perceptions.Husbands are psychological healthier than their spouses'.Individual marriage perception is correlated with his/her mental health level and his/her spouses' as well.

Objective To build the prognostic model of STBI and provide guidance for making clinical decision .Methods A total of 486 patients with STBI was collected .Six months after injury ,according to GOS ,the patients were divided into five levels :good , mild-to-moderate disability ,serious disability ,persistent vegetative state and death .Ordinal regression analysis were used to find out the main factors of different populations .Results There were significant differences between different levels in nine factors .The re-sult of ordinal regression analysis showed that GCS ,age ,rescue time and reaction of pupil to light stood as independent variables in prognosis of patients with STBI(P<0 .05) .The outcomes from the prognostic model were pretty much exactly the same as the ac-tual results(Kappa= 0 .640 ,P= 0 .026) .Conclusion Though using the prognostic model of STBI ,the present study found out prognosis was closely related to GCS ,age ,rescue time and reaction of pupil to light in patients with STBI ;thus it could provide guidance for prognosis evaluation .

OBJECTIVE:To compare clinical efficacy and safety of olanzapine and quetiapine for mental disorders elderly pa-tients. METHODS:120 elderly patients with mental disorders were randomly divided into olanzapine group and quetiapine group, with 60 cases in each group. Olanzapine group was given Olanzapine tablet orally with initial dose of 2.5 mg,qd,and then increas-ing to maximal dose 15 mg according to disease condition,qd;quetiapine group was given Quetiapine tablet orally with initial dose of 50 mg,qd,increasing to maximal dose 400 mg according to disease condtion,qd. Both groups received 6 weeks of treat-ment. Clinical efficacy of 2 groups were compared as well as PANSS and the quality score of life before and after treatment,and the occurrence of ADR. RESULTS:PANSS and the quality score of life were improved significantly in both groups,with statisti-cal significance (P>0.05);but there was no statistical significance between 2 groups (P>0.05). There was no statistical signifi-cance in clinical efficacy between 2 groups(P>0.05). The incidence of lethargy,hypotension and bradycardia in quetiapine group were significantly lower than in olanzapine group,while the incidence of tachycardia was significantly higher than olanzapine group,with statistical significance (P<0.05). CONCLUSIONS:Olanzapine and quetiapine are similar to each other in the treat-ment of mental disorders elderly patients;both of them can effectively improve the quality of life,and ADR induced by quetiapine is slighter than that induced by olanzapine.

Objective To investigate the functions of triple point-mutants of hypoxia-inducible factor 1α(HIF1α)in angiogenesis in bone defect region under normoxic conditions.Methods Triple point-mutations (the 402,564 and 803 amino acids)in HIF1α coding sequence (CDS)were induced.The triple mutant of HIF1α(402/564/803)was inserted into the adenovirus pAdEasy-1 system to complete viral packaging and titer measurements. The wild-type HIF1α gene and the empty adenovirus vector were packaged in the same way.For the in vitro experiment,the rabbit bone marrow mesenchymal stem cells (MSCs)were divided into four experimental groups:A,MSCs infected with viral solution containing mutant HIF1α;B,MSCs infected with viral solution containing wild-type HIF1α;C,MSCs infected with viral solution without any HIF1α;and D,MSCs without viral infection. The efficiency of infection was observed by the expression of human renilla reniformis green fluorescent protein (hrGFP).The expression levels of HIF1α mRNA and protein in infected cells in each experimental group were measured.For the in vivo experiment,the MSCs were divided into the same four groups and infected with the virus solutions from each group and cultured under normoxic conditions.At 72h after the infection,the MSCs were used as seed cells and transplanted into Apatite-wollastonite magnetic bioactive glass-ceramic (AW MGC)vector to construct artificial tissue-engineering scaffolds,and then the scaffolds were implanted into the in vivo rabbit radial bone defect model.The animals from each group were sacrificed 8 weeks after the surgery and the tissues from the implantation region were harvested for evaluation of angiogenesis.Results The 402,564 and 803 amino acids in CDS area were point mutated into alanine;three types of recombinant adenovirus were successfully constructed, packaged and characterized.The expression levels of HIF1αmRNA were significantly higher in Group A and Group B than in Group C and Group D (P <0.05 ).There was no significant difference between Group A and Group B group or between Group C and Group D (P >0.05 ).The HIF1α protein expression in Group A was significantly higher than that in the other three groups (P <0.05);however,there was no significant difference among groups B,C and D (P >0.05).There was prominent angiogenesis in bone defect region in Group A,but not in the other three groups.Conclusion ① Triple point-mutants of HIF1αefficiently expressed functional proteins under normoxic conditions.② Triple point-mutants of HIF1αeffectively promoted in vivo angiogenesis in bone defect region.

Objectives:To explore the effects of love resources and the lovers'resources equivalence on their romantic relationship quality.Methods:A sample of 203 pairs of lovers from 5 provinces and municipalities were selected(aged from 15 to 29).They were assessed with the Evaluation Form of Love Resources for Individual(EFL-RI)and the Scale of Relationship Perception Index for Unmarried People(RPUS)for the evaluation of the relation-ship between the love resource equivalence and the romantic relationship quality.The EFLRI was used to quantify the 12 individual love resources (the appearance of individual,stature,sexual health,health,personality,mental health,sense of responsibility,capacity,professional/occupation,education background,earning and family back-ground).The results included self-evaluation and peer-evaluation.Results:Self-assessment of responsibility between lovers and D-value of mental health were negatively correlated with the reported RPUS scores of both sides (r =-0.20 --0.33,Ps <0.05).The D-values of earning and family background were positively correlated with the re-ported RPUS scores of both sides (r =0.14 -0.25,Ps <0.05).Lovers'peer-evaluation of sexual health scores and the D-values of responsibility were negatively correlated with the reported RPUS scores of both sides (r =-0.25 --0.38,Ps <0.01.The D-values of professional/occupation and family background were positively correlated with the reported RPUS scores of males (r =0.20,0.18,Ps <0.05).Love resources(responsibility,sexual health,educa-tion background of males;appearance,personality,capacity of females )had positive predictability to males'repor-ted RPUS scores (β=0.14 -0.34),love resources(responsibility,appearance,personality,capacity,health of males and health,education background of females )had positive predictability to females'reported RPUS scores (β=0.14 -0.27).Conclusion:It suggests that the equivalence of responsibility resource has a positive influence for the quality of love relationship.The equivalence of family background resource has a negative effect for the quality of love relationship.

Objective To examine the relationship of marital quality,personalities,coping style in spouses.Methods Total 923 spouses were assessed with the marriage perception scale (MPS),Eysenck personality questionaire(EPQ) and simplified coping style questionnaire(SCSQ).Results The results revealed that psychoticism and neuroticism were both negatively correlated with marital quality(r=-0.24,-0.31,P＜ 0.01),but intraversion/extraversion and lie were both positively correlated with marital quality (r =0.24,0.14,P ＜ 0.01).And coping style was positively correlated with marital quality(r=0.33,P＜ 0.01).Significant partial mediation of coping style on the association between personality and marital quality were revealed,and the mediating effect was accounted for 8.8％ of the total effect.Conclusion Coping style is the mediator between personalities and marital quality.

Objective To explore the structure of Chinese personality based on natural language and to develop a Chinese personality vocabulary data bank.Methods Based on the sub-factors of Chinese personality scale(QZPS),Chinese personality assessment inventory 2(CPAI-2) and Chinese personality five factors inventory (CPFFI),a self-reported personality questionnaire with 116 items was developed.An exploratory factory analysis and parallel analysis were made to the data collected from 1455 Chinese participants.Results A Chinese Personality Seven Factors Inventory (CPSFI) was developed,which included seven factors with 52 items.51.63％ of the total variance of the seven factors was explained and the internal reliability coefficient was 0.800,while the internal reliability coefficients among the factors were between 0.663-0.912.The retest reliability coefficients of the factors were between 0.700-0.874 (P ＜ 0.01).Conclusions Outgoing and emotion are the core contents of the crossculture personalities.Most of the factors in QZPS,CPAI-2 and CPFFI can be found in the seven factors structure,of which the structure is clearer.

Objective To transform the vocabulary based Chinese personality (VBCP) to a sentence based Chinese personality inventory.Methods Based on the dimension theory and mapping sentence,347 sentences were developed and quantified with equal weight.772 subjects participated in a pilot study and an exploratory factor analysis was conducted to the collected data.A trial version of the Chinese Personality Inventory with 7 factors was developed.With the trial version as the survey instrument,3190 subjects from 22 provinces and centrally administered municipalities in China participated in the survey,the exploratory factor analysis,confirmatory factor analysis,annova,t-test,correlation and cronbach test were utilized in this research.The Chinese seven factors personality inventory (CSPI) was developed,which included seven factors with 130 items.Results The 7 factors of Chinese personality inventory were emotion,innovation,persistency,virtue,extraversion,agreeableness and tradition.42.27％ of the total variance of the seven factors was explained.The internal reliability coefficient was Cronbach' s α =0.902(P＜0.001),while the internal reliability coefficients among the factors were between 0.794-0.947.The retest reliability coefficients of the factors were between 0.696-0.921 (P＜ 0.001).Significant positive correlations (r ranged from 0.151 to 0.548,P＜0.01)were found between 5 of the 7 factors of CSPI,but innovation and tradition.Significant positive correlations (r ranged from 0.193 to 0.715,P＜0.05,P＜0.01)were found between the 7 factors and CSPI.Significant correlations between CSPI and EPQ-RSC were found (P＜0.05).Confirmatory factor analysis showed that thc inventory was valid,and NFI and CFI were greater than 0.90.Conclusion CSPI met the measurement requirement in validity,reliability and explanation ability.

BACKGROUND:Schizophrenia is a kind of psychosis which pathogenesis is unknown yet, and its pathogenesis is a key study theme all over the world. Recently it is concerned in genetic study, particularly in the molecular genetics. Among them, it shows a good prospect in researching the candidate functional gene. OBJECTIVE:To analyze the association between the T102C polymorphism of serotonin 2A (5-HT2A) receptor and schizophrenia. DESIGN: A diagnosis-based ease observation and association analysis. SETTING: Second Affiliated Hospital, Xinxiang Medical College and the 13 Branch of General Hospital of Zhongyuan Oil Field. PARTICIPANTS: In the patient group, there were 56 cases of schizophrenie probands, who were hospitalized in the Second Affiliated Hospital of Xinxiang Medical College from August 2003 to April 2004, and their healthy parents (n=112) were also enrolled as the parents group. METHODS:The nuclear family consisted of 56 probands, who met the diagnostic criteria of the third edition of Chinese Classification and diagnostic criteria of Mental Disorders (CCMD-3), and their parents were detected with polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP), the genotype and the T102C polymorphism of schizophrenic 5-HT2A receptor were detected with transmission disequilibrium test (TDT). MAIN OUTCOME MEASURES:The results of allele and genotypic frequency, and the goodness-of-fit for Hardy-Weinberg equilibrium of 5- HT2A receptor, as well as the TDT analytical results of 5-HT2A receptor gene, were observed. RESULTS:All the 56 patients and the 112 parents were involved in the analysis of results. ①No significant differences were found between the patient group and parents group in the genotypic frequencies (χ2 =4.423, P=0.110) and allele distribution (χ2=1.147, P=0.563), and there was a good goodness-of-fit for Hardy-Weinberg equilibrium. ② In the 56 families, the transmission disequilibrium of 39 nuclear families with paternal or maternal genotype of heterozygote detected by TDT showed no association between schizophrenia and 5-TH2A receptor gene (χ2=2.703, P=-0.10).CONCLUSION: There is no association between the 5-TH2A receptor gene T102C and schizophrenia in Chinese Han population.