Flow-diverting stent that appears in recent years is a new method for the treatment of complex intracranial aneurysms.This article reviews the principles,composition,development,advantages and disadvantages,indications,main complications and some problems of flow-diverting stent.

Objective To study the diagnosis of double image of intracranial hematoma by CT and MRI.Methods There were 27 cases with twice blood of the same part of intracranium,of them,23 cases presented double image of intracranial hematoma,18 cases were intracerebral hematoma,3 cases were subdural homatoma and 2 cases were extradural homatoma.Results The double image of intracerebral hematoma was caused by twice blood in different time at the same region of intracraniun that became high and slightly high density.MRI exhibited signal intensity of acute and subacute or chronicity premature hematoma.Conclusion The double image of intracerebral hematoma should differentiate with cerebroma bleeding and cerebroma calcification

Objective The present study was aimed at investigating the regeneration promoting mechanism of forskolin and IBMX on injured retinal ganglion cells(RGCs). Methods Fluorescent retrograde labeling and autologus sciatic nerve transplanting techniques were used to observe the effects of H 89 or/and wortmannin on the regeneration promoting effects of forskolin and IBMX on injured retinal ganglion cells by intravitreal injection. Results Both H 89 and wortmannin could partly block the promoting effects of forskolin and IBMX on regeneration of injured RGCs, the effects of wortmannin might be more powerful, if united, they could inhibit the effects of forskolin and IBMX completely.Conclusion The regeneration promoting effects of forskolin and IBMX on injured RGCs might be realized by PKA CREB and PI3 K Akt accesses.

ObjectiveTo analyze the relationship of depression after stroke with the location of lesion and the leve l of central nervous system (CNS) damage, and evaluate the treatment effect.Methods86 stroke patients were evaluated by Zung's self-rating depression scale (SDS). If SDS score ≥50 points, the patient was s elected as subjects for this study and treated with fluoxetine. The relationship of depression with the location of lesion and the level of CNS damage, and the treatment effect were analyzed.ResultsThere were 3 4 cases evaluated as depression (with 27 light depressive cases, 7 moderate depr essive and severe depressive cases). The symptom of depression has a positive co rrelation to the damage level (P<0.05). The depression inci dence of patients with acute sub-cortex stroke is higher than that of cerebral cortex and cerebellum stroke (P<0.01). Fluoxetine has a goo d effect on depression after stroke.Conclusions Th e symptom of depression after stroke has a positive correlation to the damage le vel. Fluoxetine has a good effect on depression after stroke.

Objective To investigate the relationship between inducible nitric oxide synthase(iNOS)mRNA expression of pancreatic tissues and intestinal permeability,and the effect of salviae miltiorrhizae on the change in gut permeability in rats with severe acute pancreatitis(SAP).Methods All rats were randomly divided into three groups:Sham operation(group C,n=15),SAP group(group SAP,n=15),and salviae miltiorrhizae therapeutic group(group T,n=15).At 24h After operation,the iNOSmRNA expressions of pancreas were determined by in situ hybridization(ISH),and blood amylase(AMY),nitric oxide(NO) and lipopolysaccharide(LPS) were examined.The histopathologic changes of pancreas and ileum were observed.Intestinal permeability was measured by means of albumin clearance(AC)of 125I-labeled rat serum albumin.Results The iNOSmRNA expressions of pancreas in group SAP were markedly increased in comparison with group T(P

A simple rapid and sensitive Dot-ELISA method was establishhed for identifying the human seminal stains by using anti-human semen monoclonal antibody (A10C6)labeled with horseradish Peroxidase of grayish color revealed a positive reaction. The results showed that the extract of human semen was positive. No Cross-reaction was observed when human tissues body fluids and animal seminal stains were tested.

Objective To investigate the changes of carotid, lipidemia and fibrinogen in type 2 diabetes mellitus patients complicated with cerebral infarction (DCI). Methods 58 cases of DCI (DCI group) were enrolled in this study, and 36 cases of cerebral infarction without diabetes mellitus served as control group. The location, number and nature of carotid atherosclerotic plaque and inner diameter of carotid artery were assessed by Doppler ultrasonography in all the patients, as well as blood lipid, blood glucose and fibrinogen were evaluated. Results In DCI group, the rate of carotid atherosclerotic plaque was 79.3%, the IMT and inner diameter of common carotid artery in DCI group were significantly different from control group (all (P

Objective To investigate the effects of Cholera Toxin(CTx)on the cAMP level and the survival as well as the apoptosis of retinal ganglion cells (RGCs) after distal axotomy of the optic nerve.Method After transecting the optic nerve intracranially, CTx was injected intravitreally. Fluorescent retrograde tracing method and TUNEL(TdT-mediated dUTP nick end labeling)technique were used to show the surviving RGCs and the apoptotic cells in the ganglion cell layer. The Brown's radioimmunoassay method was used to measure the cAMP level of the retina. Result The cAMP level of the normal retina was 6.22?2.02pmol/g/retina. The mean density of RGCs in the normal retina was 2 192?66/mm 2 and it decreased to 1 520?116/mm 2、736?39/mm 2 and 466?53/mm 2 at 1W、2W and 3W respectively after distal axotomy. The densities of RGCs in the distal axotomy groups treated with CTx and killed at 1W、2W and 3W were 1 642?122/mm 2、1 091?107/mm 2、 748?35/mm 2 respectively and were significantly higher than those of distal axotomy group without CTx treatment. Conclusions The results show that CTx can elevate cAMP level of the retina and promote the survival of RGCs and inhibit the apoptosis of RGCs after distal axotomy of the optic nerve in adult hamsters.

OBJECTIVE:To study the correlation of inorganic elements and active ingredients in Paris polyphylla. METH-ODS:HPLC was adopted for contents determination of polyphyllinⅠ,Ⅱ,Ⅵ and Ⅶ:the column was Phenomenex C18 with mo-bile phase of acetonitrile-water(gradient elution)at a flow rate of 1.0 ml/min,detection wavelength was 203 nm,and column tem-perature was 30 ℃. ICP-MS was adopted for contents determination of Na,Mg,K,Ca,Cr,Mn,Fe,Ni,Zn,Se,Sr,Mo,Pb, Cd,Hg,Cu and As:RF power was 1.55 kW,sampling depth was 10 mm,the plasma gas flow was 15.0 ml/min,carrier gas flow rate was 0.86 L/min,spray chamber temperature was 2 ℃,helium collision mode was He,gas flow was 4.5 ml/min,measurement points/peak was 6,sampling mode was hopping peak collection(repeated 3 times). And SPSS 21.0 software was adopted for step-wise regression analysis of correlation between the two above-mentioned. RESULTS:The linear range was 0.939-4.697 μg(r=0.999 8)for polyphyllinⅠ,1.124-5.620 μg(r=0.999 6)polyphyllinⅡ,0.784-3.918 μg for polyphyllin Ⅵ,0.976-4.880 μg for poly-phyllinⅦ.RSDs of precision,stability and reproducibility tests were lower than 2%,recoveries were 96.53%-100.71%(RSD=1.69%,n=6) for polyphyllinⅠ,98.19%-99.55%(RSD=0.58%,n=6) forⅡ,95.45%-100.83%(RSD=1.87%,n=6) for poly-phyllin Ⅵ,96.11%-102.01%(RSD=2.07%,n=6)for polyphyllin Ⅶ . The linear range was 0-195.984 3 mg/kg(r≥0.999 3),de-tection limit was no higher than 65.201 ng/kg. PolyphyllinⅠshowed positive correlation with Mg and negative correlation with Pb;polyphyllin Ⅱ showed positive correlation with Cu and negative correlation with As;polyphyllin Ⅵ showed positive correlation with Sr and Hg and negative correlation with Mn;polyphyllin Ⅶ showed positive correlation with Na and Ni and negative correla-tion with As;the total contents of the 4 polyphyllins showed positive correlation with Ni and Sr and negative correlation with Fe. CONCLUSIONS:The contents of inorganic elements and P. polyphylla have certain correlation with active ingredient.

Objective To analyze the clinical and laboratory results and epidemiological characteristics of brucellosis.Methods The clinical and laboratory characteristics brucellosis cases (confirmed by Brucellosis Guidelines 2012) at the Department of Infectious Disease of the First Hospital of Jilin University between 2000 and 2016,were retrospectively evaluated.The patients were divided into two groups according to acute and chronic stages.According to the range of lesions,the lesions were divided into two groups,and comparative analysis of data between groups was done.Results The ages of the 607 patients (489 males,118 females) were ranged from 2 to 80 years.Among the 607 patients,570 (93.9％) were diagnosed with acute brucellosis,37 (6.1％) with chronic brucellosis.Focal involvement was found in 418 (68.9％) patients.Among them,382 patients were in acute stage,and the other in chronic phase (36).Acute patients' alanine aminotransferase (ALT) and aspartate transaminase (AST) were higher than those of chronic brucellosis (U/L:47.2 vs 26.7,44.5 vs 24.0,Z =-3.684,-3.754,all P ＜ 0.05).Although the white blood cell count,platelet values,C-reactive protein,and blood sedimentation were higher in patients with focal involvement (x 103/mm3:7.3 vs 5.4,211 vs 176;mg/L:56.0 vs 30.5;mm/h:37 vs 28,Z =-4.407,-2.709,-2.334,-2.137,all P ＜ 0.05),patients without focal involvement had higher ALT and AST (U/L:33.3 vs 53.9,30.2 vs 48.1,Z =-4.102,-3.730,all P ＜ 0.05).Peripheral arthritis was the most common type of osteoarticular involvement in 317 patients with focal involvement,and peripheral arthritis was found to be the most frequently identified in the knee joint,112 patients (35.3％).Totally 80 patients were followed up,the relapse rate was 20.0％ (16/80),2 patients treatment failure,only 1 patient died after 1 month of treatment who was diagnosed neuropathic brucellosis.Conclusions Focal involvement should be investigated in the presence of leucocytosis,and pain of a certain part.