Objective To evaluate the efficacy and safety of entecavir(ETV)treatment on patients with chronic severe hepatitis B.Methods 82 native patients of chronic severe hepatitis B with positive HBV-DNA were divided into two groups,treatment group(37 cases) were prescribed with normal treatment plus ETV(0.5mg qd),while control group(45 cases) were treated with normal treatment alone.Symptoms,the levels of TB,ALT,PTA,HBV-DNA loads were determined before and at the end of the study.Results The effective rate of the treatment group(75.7%) were significant higher than that in the control group(53.4%)(P

Objective To investigate the narsing intervention of laparoscope and open abdominal in treating hysteromyoma.Methods 80 cases with hysteromyoma according to the different treatment methods were divided into that in Abdominal myomectomy group of 40 cases and Laparoseopic myomectomy group of 40 patients,then different methods of nursing intervention were siren to them.The surgery bleeding、operative time、hospital days and other as-pects were observed.Results The index of blood loss、intestinal function recovery time、active time away from the bed、hospital days in Laparoscopic group were better than Abdominal myomectomy group(t=2.781,t=2.845,t=2.881,t=2.844,t=2.879,all P<0.05).Conclusion Preoperative psychological care、bowel preparation and postoperative care could reduce the incidence of postoperative complications and improve surgical success rate.

0.05),marrow restrain is much lower than chemical-treatment medicines with the difference significant(P

Objective:To evaluate the efficiency and safety of fraxiparin in the treatment of patients with ACS. Method:137 patients with acute coronary syndrome(ACS)were randomly assigned to fraxiparin treatment and enoxaparin treatment for 7 days.Result:129 cases completed the whole trial and the results were obtained from ITT.The heart death rate was not statistically different between the two groups during the treatment.No Q segment acute myocardial infarction occurred.Both drugs statistically decreased CK CKMB and TnT.There was no significant difference between the two groups regarding these changes.Only two minor adverse reactions occurred and became normal soon after nadroparin withdrew. Conclusion:Fraxiparin and enoxaparin had similar efficiency and safety in the treatment of patients with ACS.

Objective To observe the migration paths of disk fragment in the anterior epidural space (AES). Methods Eighteen operation-proved cases with herniated nucleus pulposus of lumbar disk were collected and the MR findings were retrospectively reviewed. Results The disk fragments moved in a superior (12 cases,67%) or inferior (6 cases,33%) direction from the donor disk. 10 cases occurred in right septum and 8 cases in left septum. The displaced disk components were most frequently dislodged into the right or left AES, and rarely straddled the midline. On sagittal T 2WI, fragments exhibited low or intermediate signal intensity and compressed the dura mater of spinal cord. On T 1WI, fragments exhibited intermediate signal intensity and compressed the PLL and the spinal cord. On axial T 2WI, fragments exhibited compression of the PLL, the midline septum, and the dura mater of spinal cord. On fat-suppression scan, fragments exhibited increased signal intensity. Conclusion The migrating path of a disk fragment is determined by the anatomy of the AES. Fat-suppression scan has a clinical diagnostic significance.

The nutritional support has become an important part of the management of pa- tients with severe head injury.Fifty- two cases were supported by early nutritional supplement.The result showed that themortality and morbidity were decreased.It is experienced that early nutritional support may reduce the loss of body protein and vis- ceral proteins,increase the function of cellu- lar immune system and promote the recov- ery of impaired nerves.

Zihuang Haemostat powder(ZHP)is a Chinese traditional patent medicine. Its ingredient Coptis chinenses Franch was identified by TLC. A Rp-HPLC method for detrmining emodin in ZHP was established. The TLC method was not interfered by blank sample. The Rp-HPLC method was sensitive and highly reproducible. Its average recovery was 99. 24%. RSD was 1. 21 %

SLE-like syndrome in (C57BL/6 x BALB/c) F1 mice can be induced by intravenous injection of lymphocytes from BALB/c parental mice. In these SLE-like mice levels of DNA antibody and anti—histone increased and there were immuno-complex mediated proteinuria, glomerulonephritis. 28 days later artesunate was given intraperitoneally to daily these mice. The results revealed that artesunate could significantly suppress the progression of disease activity,

Objective To investigate the effect of the modified and controllable sigmoid colostomy in ostomy operation.Methods Sixty patients were divided into two groups.The control group (30 cases) received extraperitoneal sigrnoid colostomy while the experimental group (30 cases) received modified and controllable sigmoid colostomy.Postoperative complications caused by sigmoid colostomy,artificial anal function,psychological disorder,life quality,and the level of tumor marker between two groups were compared.Results In experimental group,4 patients (13.33％,4/30) at postoperative 6 months and 1 patient (3.33％,1/30) at postoperative 12 months suffered from complications caused by sigmoid colostomy.The incidence rate of complications caused by sigmoid colostomy was higher in control group[30.00％(9/30) and 10.00％(3/30)],but there was no significant difference (P ＞ 0.05).In experimental group,the defecate controllable and times were increased,18 patients (60.00％,18/30) could freedom control defecation,14patients (46.67％,14/30) defecation times ≤3 at postoperative 12 months.But there were 11 patients (36.67％,11/30) and 8 patients (26.67％,8/30) in control group,there was significant difference (P ＜0.05).The rate of human communication disorders,self abasement,anxiety and disappointment in experimental group at postoperative 12 months were significantly lower than those in control group (P ＜ 0.05).The rate of pessimism,loneliness and fear between two groups had no significant difference (P ＞ 0.05).In the evaluation of QLQ-C30 scale,aside from recognition function and financial straits had no significant difference(P ＞ 0.05),others scores in experimental group were significantly better than those in control group (P ＜ 0.05 or ＜ 0.01).In the evaluation of QLQ-C38 scale,the scores in experimental group at postoperative 12 months were significantly better than those in control group (P ＜ 0.01 or ＜ 0.05).At postoperative 12 months,the level of carcinoembryonic antigen,cancer antigen 125 and cancer antigen 199 in experimental group were significantly lower than those in control group (P ＜ 0.05).Conclusion The modified and controllable sigrnoid colostomy has the advantages,less complications,controllable,simple,safe and it is worthy of application more widely in clinical practice.

Objective To compare nasal intermittent positive pressure ventilation （NIPPV） with nasal continuous positive airway pressure (NCPAP) treatment of primary apenea of premature (AOP) effect,and provide a scientific basis for the AOP treatment.Methods Seventy-six cases of children with AOP were randomly divided into NIPPV group (40 cases) and NCPAP group (36 cases).Comparison of two groups changes of blood gas,curative effect,after treatment for invasive mechanical ventilation ratio,ventilation time,and so on.Results Blood gas analysis of two groups before treatment had no significant difference (P ＞ 0.05),1,12 h after treatment of blood gas analysis was statistically significant (P ＜ 0.05).The cure rate,effective rate and inefficiency in NIPPV group were significantly better than those in NCPAP group [82.5％ (33/40)vs.61.1％ (22/36),92.5％ (37/40) vs.80.6％ (29/36),7.5％ (3/40) vs.19.4％ (7/36)].Assisted ventilation time was significantly shorter in NCPAP group[(39.45 ± 6.99) h vs.(69.39 ± 20.51) h].The difference was statistically significant (P ＜ 0.05).Two groups of intraventricular hemorrhage,bronchial pulmonary hypoplasia,neonatal necrotizing enterocolitis incidence rate had no significant difference (P ＞0.05).In NIPPV group the incidence rate of premature infant retina disease and cererbral white matter softening around the ventricle was significantly lower than that in NCPAP group [2.5％ (1/40) vs.13.9％(5/36),2.5％(1/40) vs.11.1％(4/36)].The difference was statistically significant (P ＜ 0.05).Conclusion NIPPV in the treatment of recurrent apnea in premature infants curative effect and prognosis is better than NCPAP.