1.Estrogen receptor expression in genioglossus of ovariectomized rats
Journal of Practical Stomatology 2001;0(03):-
Objective:To investigate the expression of estrogen receptor in genioglossus of female rats. Methods:30 female Sprague-Dawley rats were randomly assigned to three groups: normal group(NORMAL), sham operation group (SHAM) and ovariectomized group(OVX). The rats were sacrificed 6 weeks after surgery, and the genioglossus was removed for analysis. The expression of estrogen receptors(ER? and ER?) was examined by immunohistochemical assay. Results:ER? and ER? were found in genioglossus of normal rats. The expression of ER? was significantly higher than ER? (P0.05). Conclusions:Estrogen receptors are expressed in genioglossus of female rats.ER? expression is significantly impacted by the estrogen level.
2.Wavelet-based denoise of body-surface electrogastrogram signals
Yuxia XIE ; Wensheng HOU ; Xiaoying WU
Chinese Medical Equipment Journal 1993;0(05):-
Body-surface electrogastrogram signals can be adopted in studies of gastrodynamics characteristics and diagnoses of functional gastric diseases. Fundamental theory of denoise by wavelet introduced, wavelet transfer is applied to the denoise of body-surface electrogastrogram signals. The high-frequency noise is eliminated through wavelet, and thus the SNR and the resolution ratio of the signal are increased.
3.Pulmonary hypertension in patients with chronic obstructive pulmonary disease: clinical characteristics and risk factors
Tongsheng WANG ; Yimin MAO ; Yuxia SUN ; Weiwei HOU ; Yuxuan FENG ; Hongpei QU
Chinese Journal of Internal Medicine 2015;54(12):1037-1040
Objective To investigate the clinical characteristics of pulmonary hypertension(PH) in patients with chronic obstructive pulmonary disease (COPD) and study the related risk factors.Methods Patients with stable COPD enrolled in this study,undergoing examinations including full pulmonary function tests (PFT),6-minute walk distance (6MWD),Exercise Oxyhemoglobin,Saint.George's respiratory questionnaire (SGRQ) and transthoracic echocardiography.Pulmonary artery systolic pressure (sPAP) ≥ 36 mmHg(1 mmHg =0.133 kPa) was defined as PH.Results A total of 251 patients were finally evaluable in this study.The frequency of PH was 55.4% (139/251) in patients with stable COPD.Significant differences were seen between patients with PH and without PH respectively in the following factors (mean P <0.05):proportion of age ≥ 60 years (69.8% vs 57.1%),forced expiratory volume in one second (FEV1)(% predicted) [(47.5±8.2)% vs(61.2±10.2)% and(49.8±7.9)% vs(66.4±11.3)%],sPAP [(41.9 ± 9.1) mmHg vs (28.2 ± 3.2) mmHg],exercise oxyhemoglobin desaturation [(-5.5 ± 3.2) % vs(-2.2 ± 1.2) %],6MWD [(316.0 ± 55.2) m vs(390.0 ±75.2) m].The following variables were negatively correlated with sPAP:6MWD (r =-0.330,P =0.003),FEV1 (% predicted) (r =-0.210,P =0.024 and r =-0.130,P =0.012,respectively).The following variables were positively correlated with sPAP:age(r =0.560,P =0.031),exercise oxyhemoglobin desaturation > 3% (r =0.540,P =0.001).Logistic regression test has showed that age≥ 60 years,exercise oxygen desaturation > 3%,FEV1 (% predicted) < 50%,6MWD < 350 m were risk factors for PH in COPD.Conclusion The incidence of PH in COPD increases with age,yet the performance of lung function and the activity of endurance decrease in elder patients.Sixty years or older,exercise oxygen desaturation > 3%,FEV1 (% predicted) < 50%,6MWD < 350 m are risk factors of PH in COPD.Echocardiography or right heart catheterization when needed should be considered to confirm the diagnosis.
4.The effects of presurgical nasal mode combined with nasal diorthosis in the treatment of nasal deformity and incomplete unilateral cleft lip
Zhanping REN ; Yongwei TAO ; Huiqin CAO ; Yuxia HOU ; Jinfeng LI ; Siwei MA
Journal of Practical Stomatology 2014;(6):800-804
Objective:To evaluate the effect of presurgical nasal mode(PNM)combined with nasal diorthosis in the treatment of na-sal deformity and incomplete unilateral cleft lip(IUCL)in infants.Methods:35 infants with IUCL were treated by PNM followed by nasal diorthosis and cheiloplasty.The nasal asymmetry was analysed by measurments of nostrils height,nostrils width and nasal colu-mella angle skewness on the photographs at the initial visit(T0),pre-operation(T1),1 week after operation(T2),1 month after opera-tion(T3)and a year after operation(T4).The other 35 infants with IUCL without PNM treatment were served as the controls.Re-sults:Compared with the controls,the symmetry of nostrils height,nostrils width,nasal columella angle skewness in PNM treated children were significantly improved at T0-T1 and T1-T2(P <0.05).there was no significant difference at T2-T3 and T3-T4(P >0. 05).Conclusion:Nasal asymmetry can be improved by presurgical nasal mode treatment followed by preliminary nasal deformity di-orthosis and cheiloplasty.
5.Evaluation of Sander Ⅱ appliance in the treatment of Angle Ⅱ malocclusion with mandibular retrusion of adolecents
Xinqin SI ; Xianglin LI ; Yang LI ; Yuxia HOU ; Fei WANG ; Feng PAN ; Lu LIU
Journal of Practical Stomatology 2016;32(2):248-251
Objective:To evaluate the effects of Sander Ⅱ appliance in the orthodontic treatment of adolescent ClassⅡmalocclusion. Methods:15 cases (6 male and 9 female)of adolescent ClassⅡ malocclusion with mandibular retrution were treated with Sander Ⅱappliance.Pre-treatment and post-treatment Lateral cephalogram measurements were traced and analyzed in terms of 28 indicators. SPSS 19.0 software package was used for paired t test.Results:After treatment,15 patients achieved remarkable improvement in the maxillofacial profile and normal overjet of teeth.The cephalometric analysis showed that ANB,OJ,H°and U1-E decreased(P <0. 05),SNB,B-OLP,Pg-OLP(mm),Ii-OLP,Ms-OLP(mm),Mi-OLP(mm),N-Me,ANS-Me,S-Go,Go-Gn,N'-Pg'/FH,Cm-Sn-Ls and Pg-Pg'increased(P <0.05).There was no significant change in SN-MP,SN-OL and Y-axis before and after treatment. Conclusion:Sander Ⅱ appliance is effective in the treatment of adolescent early Class Ⅱmalocclusion.
6.The correlation study between early postsurgery phonetic acquisition of speech stop and speech outcomes of the children aged 30 months after cleft palate repair
Siwei MA ; Li LU ; Binting YANG ; Zhanping REN ; Yuxia HOU ; Yixi WEN
Journal of Practical Stomatology 2015;(2):250-254
Objective:To study the correlation between early postsurgery phonetic acquisition of speech stop and speech outcomes of young children.Methods:28 children with cleft palate were included in the study.An one-stage palatal repair procedure was per-formed by one surgeon for the children before the age of 1 8 months.Naming tests were used in the speech therapy room when the chil-dren were aged 23 months and 30 months.Stop consonant inventory number,percent correct consonants(PCC),percent correct man-ners(PCM)and percent correct places(PCP)were analyzed.Results:Number of stop consonant was significantly correlated with PCC,PCM and PCP at 24 and 30 months of age in the children.Coefficient of determination between stop consonant number and PCC was 0.535.Conclusion:Speech stop may be used as the “sensitive sound”for the analysis of speech development of the chinese children aged 2-3 years after cleft palate repair and as the individuation guideline to determine the best assessment and therapy time.
7.The effects of dynamic support-inducing exercise on the motor function of a hemiplegic lower extremity after stroke
Keshu CAI ; Guangxu XU ; Hong HOU ; Yuxia WU ; Wenchao YI ; Ying SHEN ; Yabei FAN ; Yu LUO ; Xiao LU
Chinese Journal of Physical Medicine and Rehabilitation 2012;34(9):665-668
Objective To study the effects of dynamic,support-inducing exercise on the support,balance and gait ability of patients with moderate-to-severe hemiplegia after stroke.Methods Fourteen stroke patients were randomly assigned to an experimental or a control group (7 cases to each).The patients in the experimental group received both dynamic,support-inducing exercise and routine exercises,while the patients in the control group received routine exercises only.Before training and after 40 and 60 days of training,their functional capacity was evaluated with the Chinese stroke scale (CSS) for neurological deficits,Berg's balance scale (BBS) and using functional ambulation categories (FACs).Results Before training there was no inter-group difference in average CSS or BBS scores or in FACs.For the experimental group there were significant intra-group differences compared with 0th day in all three items at both time points.At days 40 and 60 there were also significant intra-group differences in BBS scores and FACs in the control group,and CSS scores improved significantly only in the experimental group.At day 40 there were significant inter-group differences in average CSS,BBS and FAC results.However,by day 60 a significant difference persisted only in average CSS scores.Conclusions Dynamic,support-inducing exercise can improve support,balance and gait in patients with moderate-to-severe hemiplegia after stroke.
8.Three-dimensional reconstruction and orthognathic surgery simulation system of craniofacial region based on cephalograms and laser scanning.
Hong ZHOU ; Yanning ZHANG ; Yaopu FENG ; Yuxia HOU
West China Journal of Stomatology 2011;29(4):339-343
Craniofacial malformation was related to the shape and structure of the teeth, jaws and face. Assessment of craniofacial complex in three-dimensional (3D) has long been a focus for many researchers. At present, 3D imaging techniques could reconstruct the craniofacial soft tissue or hard tissue successfully. However, they couldn't reflect the comprehensive structure of craniofacial complex. For the study of the craniofacial complex, combination of 3D imaging techniques provides a promising way toward optimum 3D imaging. The purpose of this study was to reconstruct the 3D images of craniofacial hard and soft tissue based on cephalograms and laser scanning, to found the 3D measurement and orthognathic simulation and forecast system, which may provide a new method for analyzing of craniofacial malformation, and for the quantity control and evaluation of treatment results in the orthodontic treatment, orthopedics and plastic operation.
Face
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Humans
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Image Processing, Computer-Assisted
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Imaging, Three-Dimensional
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Lasers
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Orthognathic Surgery
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Tomography, X-Ray Computed
9.A genome-wide RNAi screen identifies genes regulating the formation of P bodies in C. elegans and their functions in NMD and RNAi.
Yinyan SUN ; Peiguo YANG ; Yuxia ZHANG ; Xin BAO ; Jun LI ; Wenru HOU ; Xiangyu YAO ; Jinghua HAN ; Hong ZHANG
Protein & Cell 2011;2(11):918-939
Cytoplasmic processing bodies, termed P bodies, are involved in diverse post-transcriptional processes including mRNA decay, nonsense-mediated RNA decay (NMD), RNAi, miRNA-mediated translational repression and storage of translationally silenced mRNAs. Regulation of the formation of P bodies in the context of multicellular organisms is poorly understood. Here we describe a systematic RNAi screen in C. elegans that identified 224 genes with diverse cellular functions whose inactivations result in a dramatic increase in the number of P bodies. 83 of these genes form a complex functional interaction network regulating NMD. We demonstrate that NMD interfaces with many cellular processes including translation, ubiquitin-mediated protein degradation, intracellular trafficking and cytoskeleton structure.We also uncover an extensive link between translation and RNAi, with different steps in protein synthesis appearing to have distinct effects on RNAi efficiency. Moreover, the intracellular vesicular trafficking network plays an important role in the regulation of RNAi. A subset of genes enhancing P body formation also regulate the formation of stress granules in C. elegans. Our study offers insights into the cellular mechanisms that regulate the formation of P bodies and also provides a framework for system-level understanding of NMD and RNAi in the context of the development of multicellular organisms.
Animals
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Animals, Genetically Modified
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Caenorhabditis elegans
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genetics
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Cytoplasmic Structures
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Gene Expression Regulation
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Genes, Helminth
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Genome, Helminth
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genetics
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MicroRNAs
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genetics
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Nonsense Mediated mRNA Decay
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physiology
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RNA Interference
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RNA, Helminth
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genetics
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Reverse Transcriptase Polymerase Chain Reaction
10.Reservation versus sacrifice of remnants in the footprint area in arthroscopic repair of rotator cuff tear
Tao BAO ; Yangyang HU ; Shuoguo WANG ; Yaojia LU ; Wenyong FEI ; Erkai PANG ; Lei HOU ; Yuxia YANG ; Dianwei LIU ; Mengbo DANG ; Mingjun LI
Chinese Journal of Orthopaedic Trauma 2023;25(5):393-400
Objective:To compare the clinical efficacy between reservation and sacrifice of remnants in the footprint area in arthroscopic repair of rotator cuff tear.Methods:A retrospective study was conducted to analyze the clinical data of 32 patients with rotator cuff tear plus remnants in the footprint area (2 cm < tear size <5 cm) who had been admitted to Department of Sports Medicine, The People's Hospital of Northern Jiangsu from May 2020 to July 2021. The patients were divided into 2 groups according to reservation or sacrifice of remnants in the footprint area in arthroscopic repair of rotator cuff tear. In the remnant-reservation group (16 cases): 5 males and 11 females with an age of (61.8±9.9) years, 9 left and 7 right shoulders affected, and (3.7±1.1) cm in size of rotator cuff tear; in the remnant-sacrifice group (16 cases): 4 males and 12 females with an age of (61.3±8.8) years, 8 left and 8 right shoulders affected, and (3.9±0.9) cm in size of rotator cuff tear. The 2 groups were compared in terms of visual analogue scale (VAS), American Shoulder and Elbow Surgeons (ASES) score, Constant-Murley shoulder function score (Constant score), and range of motion of the affected shoulder before surgery, 3 months after surgery and at the last follow-up. The ratio of bilateral abductor muscle strengths (affected side/healthy side) was analyzed and compared between the 2 groups, and the healing of the rotator cuff was evaluated by MRI at the last follow-up.Results:The 2 groups were comparable because there were no significant differences in all their preoperative demographic data ( P>0.05). The 32 patients were followed up for (14.3±3.5) months after surgery. At 3 months after surgery, the VAS score in the remnant-reservation group [1.0 (0.0,1.0) point] was significantly lower than that in the remnant-sacrifice group [1.0 (1.0,1.0) point] ( P<0.05), but there was no significant difference between the 2 groups in ASES score, Constant score or range of motion of the affected shoulder ( P>0.05). At the last follow-up, the ASES score, forward flexion, abduction and ratio of bilateral abductor muscle strengths (affected side/healthy side) in the remnant-reservation group [(96.1±4.8) points, 170.0 (170.0,170.0)°, 160.0 (160.0,170.0)°, and 85.5%±13.8%]were significantly better than those in the remnant-sacrifice group [(91.4±5.9) points, 160.0 (160.0,170.0)°, 150.0 (140.0,155.0)°, and 72.6%±16.9%] ( P < 0.05), but there were no statistically significant differences between the 2 groups in VAS score, Constant score, neutral external rotation angle, or body-side internal rotation ( P>0.05). The Sugaya grading for MRI rotator cuff healing was significantly different between the 2 groups at the last follow-up ( P<0.05). Conclusion:In arthroscopic repair of rotator cuff tear, reservation of remnants in the footprint area can significantly relieve postoperative shoulder pain, and has obvious advantages in restoration of shoulder forward flexion, abduction and abductor muscle strength, leading to better healing of the rotator cuff and the large nodule than the remnant-sacrifice technique.