Objective:To study Survivin expression in oral squamous cell carcinoma(OSCC) and the effects of pingyangmycin treatment on Survivin expression. Methods:Expression of Survivin was analyzed by flow cytometry and fluorescent indirect mark monoclonal antibody technique in 22 cases of OSCC before chemotherapy,22 cases of OSCC after chemotherapy with pingyangmycin and 8 cases of normal oral mucosa.The Survivin expression was quantified as fluorescence index(FI).Results:The FI in normal oral mucosa,OSCC before chemotherapy and OSCC after chemotherapy with pingyangmycin was 1.0?0.05,1.41?0.06 and 1.22?0.14 respectively(P

OBJECTIVE: To provide references for the retail pharmacies on market competition. METHODS: The customer satisfactory idea and the customer delivered value theory were analyzed and the ways to enhance the customer delivered value were discussed. RESULTS & CONCLUSIONS: Decreasing drug price is just one among the multi-methods to enhance the pharmacy customer satisfaction. The pharmacies should analyze multi-factors influencing the customer delivered value before making correct marketing strategies.

OBJECTIVE:To provide references for Chinese pharmaceutical enterprises in establishing developmental strategy for generic drug market.METHODS:This study was bases on the theory of marketing together with literature re?trieval and demonstration analysis.RESULTS&CONCLUSION:This paper has summarized the chief problems lies in the Chinese generic drug market and put forward some feasible strategies for the pharmaceutical enterprises such as to choose va?rieties of specific features based on the characteristics of enterprises;to achieve innovation in the marketing and to focus on the country market so as to enlarge the market share;to establish strategic alliances so as to strive to be the leader of generic drugs through collaboration and competition;to occupy the top market by establishing brands for generic drugs.

OBJECTIVE:To provide references for the improvement of membership system in Chinese drugstores.METHODS: Problems in the membership system were analyzed and concrete suggestions were put forward accordingly.RESULTS & CONCLUSION:The membership system of Chinese drugstores remains to be improved,and it needs to be deepened further in practice.

OBJECTIVE:To explore the orientation of drugstore clerk’s work role.METHODS:Marketing Grid theory was put forward through analyzing the present wrong-position of drugstore clerk.RESULTS&CONCLUSIONS:Drugstore clerk should locate their right role in work and try to avoid wrong position,and they should take“Shopping Guide”clerk as their chief orientation.

OBJECTIVE:To promote the effective development of hospital pharmaceutical care in China.METHODS:To analyse the disciplines closely related to hospital pharmaceutical care separately.RESULTS&CONCLUSION:Multidisci?plinary support is the basic feature of hospital pharmaceutical care.The cooperation among various technical persons is a deci?sive factor in effective development of hospital pharmaceutical care.

OBJECTIVE:To introduce a customer - centric management strategy, i.e, customer value management (CVM). METHODS: Theory of customer value management and customer value analysis were applied in combination with the actual situation of pharmaceutical enterprises.RESULTS & CONCLUSION:Pharmaceutical enterprises should pay great attention to CVM strategy to continuously fulfill customer demands.

Objective To explore the effect of case teaching method based on ADDIE model in the teaching of surgical nursing. Methods Two classes of the four-year nursing specialty college students (39 students in each class, 78 students in total) in the third grade were selected as samples. According to the principle of randomization, one class was set as the observation group, and the ADDIE model based on case teaching method was adopted. According to the five stages of ADDIE model, namely, analysis, design, development, implementation, and evaluation, the whole process was performed to achieve teaching goals and timely combination of clinical cases, so that the theoretical knowledge of teaching materials and clinical reality were highly connected. The other class was set as the control group. At the end of the semester, the teaching results were evaluated based on two groups of students' test scores and questionnaire findings. SPSS13.0 software was used for statistical analysis. t-test was used to test the significance of the test results,and chi square test was used to test the significance of the survey data. The results of the two teaching methods were compared with the control group. Results The scores of the two groups were significantly higher than those of the control group [(87.0±7.1) vs (78.0±8.6), P=0.000; (93.0±2.4) vs (85.0±3.8), P=0.000]. Significantly more students in the observation group (P<0.05) were satisfied with the teaching methods used to improve the enthusiasm and initiative of learning, improve their interest in learning, broaden their knowledge, improve the effect and efficiency of learning, inspire students to think, associate, and innovate, activate classroom atmosphere, improve the ability of students to analyze and solve problems, apply theories in practice, and accurately grasp the basic concepts and theoretical knowledge. Conclusion The case teaching method based on ADDIE model can effectively improve the teaching quality of nursing courses and improve students' ability to analyze and solve problems. It is well received by students, and it can enhance teachers' teaching skills as well.

OBJECTIVE:To keep abreast of the consumer demand about using drugs and to provide information for the production and marketing business of the pharmaceutics METHODS:To give an account of the present situations of the perceptual consumption and relevant marketing tactics in China and to analyze them RESULTS AND CONCLUSION:We have pointed out the situations of awareness of the perceptual consumption and the marketing tactics in China,which fits in with the perceptual consumption at present

Objective To investigate the effects of astragalus membranaceus parenteral solution combined with recombinant human erythropietin (rHuEPO) on erythrocyte immunity function in patients with hemodialysis. Methods Fifty-one patients of chronic renal failure(CRF) with hemodialysis were divided into 2 groups randomly according to whether treated with astragalus membranaceus parenteral solution or not(therapeutic group, was 26 cases and control group was 25 cases). IgG, IgA, IgM, RBC-C3b,RR,RBC-ICR, erythrocyte percentage of CD35 positive and SOD was measured before treatment and 8 weeks after treatment. Results After 8 weeks' treatment, IgG,IgA,IgM levels in therapeutic group and IgG,IgA levels in control group were higher than those before treatment(P < 0.01 ). IgM [ (2.03±0.73 ) g/L ] was higher than that in control group (P< 0.05). RBC-C3B,RR, erythrocyte percentage of CD35 positive and SOD were higher and RBC-ICR was lower than those before treatment in two groups (P < 0.05 ) ;compared with that in control group, RBC-C3b, RR was higher [(10.85±2.31 )% ] and RBC-ICR was lower [(5.34±1.91 )% ] (P < 0.05 ).Conclusion Astragalus membranaceus parenteral solution combined with rHuEPO is superior to improve CRF patients' levels of immune globulin and erythrecyte immunity function.