This paper deals with the susceptibility of 8 inbred and 1 outbred mouse strains infected with L. donovani. Each mice was inoculated intraperitoneally with 3?106, 9?106, 2?107 amastigotes and was killed on 29-30 th, 48-49 th, 58-59 th day after infection for examination respectively .Except one of C57BL strain received 3 ? 106 amastigotes,the results showed that all mice of 615 ,C57BL ,SMMC/C?615 strains became positive at autopsy with a highly intensive infection .The greater the amastigotes was inoculated,the havier the infection would be.The 3 strains, therefore, were susceptibility to acute infection of L.donovani.The other mouse strains failed to be infected(SMMC/B, SMMC/C, ICR/JCI and Kunming strains)or only showed mild infectons(SMMC/A and SMMC/D), indicating that these 6 mouse strains were relatively resistant to infection with the parasites. In the light of the origin of these mouse strains it seems that the genetic control is highly concerned in the host susceptibility to L. donovani.

The causes of cerebral palsy are multifactorial, including antenatal, intrapartum and postnatal. Domestic scholars generally believed that intrapartum and postnatal factors are the main reasons for cerebral palsy, while in recent years, the foreign scholars suggest that prenatal factors account for the majority of the causes of cerebral palsy. This paper is to review the recent research on the causes of cerebral palsy and to introduce the theory of etiological pathway and determine the period of brain injury in cerebral palsy patients.

Male mice weighting 25-32g were infected with larvae of Trichinella spiralis. Skin administrations of mebendazole composite cream were carried out on the mice in 3 different experiment groups. It was found that there were the reduction rate of worms at 97.3%, 100% and 99. 7% in the adult worm group (50 mg/kg x 1 d), in the invasive larvae group (25 mg/kg x 7 d) and in the encysted larvae group (25 mg/kg x 7 d), respectively. These results indicate that mebendazole composite cream is very effective against both intestinal and muscular phases of T. spiralis.

Microfilariae (mff) obtained from the peritoneal cavities of infected jirds (Meriones unguiculatus) were injected intravenously into 6 mouse strains: SMMC/B, BALB/cCR, LACA, ICR/JCL, 615 and Kunming strain. The mff in the peripheral blood of the 6 mouse strains in the above sequence were detectable within 1-150, 24-80, 30-60, 3-96, 12-45 and 45-60 days after inoculation of 2 ? 105 mff per mouse. The survival period of mff was longer in SMMC/B mice than in mice of the other strains, and the density of mff in blood was also higher in the former than in the latter. Out of 18 SMMC/B mice 13 remained microfilaria-positive on the 60th day after inoculation. The duration and level of microfilaraemia were proportional to the dose of parasites injected Microfilariae disappeared from the peripheral blood of all mice 3 days after injection of 1 ?104 mff, but were still detectable 60 days after injection of 2 ? 105 mff. In addition, mff disappeared much faster from the peripheral blood of SMMC/B mice after the second inoculation than after the first one. Although the mff had already disappeared from the peripheral blood of the infected and reinfected mice for about 1 to 2 months, they could still be found in the internal organs, mostly in the small blood vessels of the lungs (about 90%). The mff maintained a nocturnal sub-periodicity in the recipient mice, similar to those observed in the donor jirds, with a peak density hour between 2:28 and 5: 48 a.m.The results show that this mouse model might be a simple and useful system in which various factors controlling the fate of mff can be studied independently.

Objective To discover the distribution of ammonia nitrogen in groundwater of Shunyi District and its influencing factors. Methods 286 monitored points in low-flow period and 100 in high-flow period were chosen in 19 towns in Shunyi District. Concentrations of ammonia nitrogen, iron and manganese, and the total bacterial count of water samples were determined and evaluated based on the Guidelines for Drinking Water Quality and related standard during Jan.-Mar., Aug.-Sep., in 2005. Results All the monitored points were deep groundwater. The median of ammonia nitrogen concentration in groundwater was 0.010 mg/L in low-flow period, and 0.140 mg/L in high-flow period. The relativity was not found between the concentration of ammonia nitrogen,total bacterial count in water sample and pollution source around the well. However the concentration of ammonia nitrogen was positively correlated with the concentration of nitrite nitrogen(r=0.224, P

cases of plasma cell mastitis were treated from 1986 to 1999,of whom 37(32.5%) suffered from subareolar abcess and sclerosis,77(67 5%)had subareolar fistula.There were 58 cases(50 8%)of crater nipple.We adopted an arc incision along the edge of areolamammae to remove the necrotic tissues of the ducts,followed by everting suture and mamilliplasty.104 cases(91 2%)achieved healing by first intention.The operations were well done with little injury.Moreover,patients would be satisfied with the appearance.

Proposed definition of cerebral palsy(CP) is a group of disorders of the development of movement and posture, that are attributed to non-progressive disturbances that occurred in the developing fetal and infant brain. Types of cerebral palsy are divided into spastic(diplegia, hemiplegia, quatriplegia), dyskinetic(athetotic, dystonic), ataxic (simple ataxia, ataxic diplegia), and mixed CP(primarily spasticity with athetosis).

Objective To investigate the clinical and intellectual characteristics of children with cerebral palsy of ataxia type.Methods Twenty-one children with cerebral palsy of ataxia type were evaluated by the illness history,clinical physical examination,brain MRI scan and intellectual assessment.Results Delayed motor milestones and dysfunction of balance were found in these children,and 80.9% of brain MRI scan was abnormal as cerebellar damage,and delayed intellectual ability found in these children was ameliorated as improvement of motor function.Conclusion Cerebral palsy of ataxia type is mainly caused by cerebellar damage manifests as delayed motor function,dysfunction of balance and mental retardation.

Chromosome Deletion ; Chromosomes, Human, Pair 9 ; Craniofacial Abnormalities ; diagnosis ; Heart Defects, Congenital ; diagnosis ; Humans ; Intellectual Disability ; diagnosis