1.Clinical study on added Yokuinin To.
Kensuke NAKAMURA ; Katsumi MORI ; Togo OTA ; Toyosato KAIDA ; Yosiro SAHASI ; Yutaka TOMITA ; Teruyuki MURAYAMA
Kampo Medicine 1988;39(1):41-47
2.Studies on Mao-Bushi-Saishin-To applied to exhaustion.
Kensuke NAKAMURA ; Kazuko MURAYAMA ; Togo OTA ; Toyosato KAIDA ; Yosiro SAHASI ; Yutaka TOMITA ; Teruyuki MURAYAMA ; Katsumi MORI
Kampo Medicine 1989;39(3):221-225
3.Nuclear corepressor 1 expression predicts response to first-line endocrine therapy for breast cancer patients on relapse.
Zhen-huan ZHANG ; Hiroko YAMASHITA ; Tatsuya TOYAMA ; Yutaka YAMAMOTO ; Teru KAWASOE ; Mutsuko IBUSUKI ; Saori TOMITA ; Hiroshi SUGIURA ; Shunzo KOBAYASHI ; Yoshitaka FUJII ; Hirotaka IWASE
Chinese Medical Journal 2009;122(15):1764-1768
BACKGROUNDEstrogen receptor alpha (ER alpha) is the most important endocrine therapy responsiveness predictor for women with breast cancer. The accuracy of the prediction of the response to endocrine therapy was thought to be affected by involving the estrogen receptor coregulatory proteins and cross-talk between ER and other growth factor-signaling networks. Nuclear corepressor 1 (NCOR1) is one of the ER a transcription repressor. The objective of the study is to investigate the expression of NCOR1 at the protein level and pursue its predictive value for breast cancer endocrine therapy.
METHODSIn the present study, the level of expression of NCOR1 protein has been assessed by immunohistochemistry in 104 cases of invasive carcinoma of the breast. Associations between NCOR1 protein expression and different clinicopathological factors and survival were sought.
RESULTSIt was found that NCOR1 was expressed at significantly higher levels in responsive patients treated with endocrine therapy as first-line treatment on relapse. Responsive patients also had a significantly longer post-relapse survival and overall survival. No NCOR1 expression difference was found between patient by age, tumor size, lymph node status, different histological grade groups and human epidermal growth factor receptor 2 (HER2) status. Multivariate analysis showed that NCOR1 is an independent prognostic factor for over-all survival.
CONCLUSIONSIn breast cancer, NCOR1 protein expression level predicts response to endocrine therapy as first-line treatment for breast cancer patients on relapse and NCOR1 protein level assay may increase the accuracy in the endocrine treatment determination and, therefore, improving the patients survival.
Antineoplastic Agents, Hormonal ; therapeutic use ; Breast Neoplasms ; drug therapy ; metabolism ; Estrogen Receptor alpha ; metabolism ; Female ; Gene Expression Regulation ; Humans ; Immunohistochemistry ; Middle Aged ; Nuclear Receptor Co-Repressor 1 ; metabolism ; Receptor, ErbB-2 ; metabolism ; Receptors, Progesterone ; metabolism ; Tamoxifen ; therapeutic use
4.Dual-Valve Repair in Dextrocardia and Situs Inversus Totalis
Masahiro INAGAKI ; Yutaka KOYAMA ; Koshi SAWADA ; Shinji TOMITA ; Yasuhide OKAWA
Japanese Journal of Cardiovascular Surgery 2022;51(4):221-224
A 59-year-old man, diagnosed with severe mitral regurgitation, moderate tricuspid regurgitation, and chronic atrial fibrillation with situs inversus totalis, was referred to our hospital. A median sternotomy approach was performed. The surgeon operated from the left side of the operating table, and had an excellent exposure to the mitral and tricuspid valves during the operation. The mitral valve was repaired with the posterior cusp plication technique and ring annuloplasty. The tricuspid valve was repaired with ring annuloplasty. We use a conventional semi rigid ring turned over, because the tricuspid valve has an asymmetric configuration. FullMAZE, and left atrial appendage closure were performed, too. The postoperative course was uneventful.
5.Diarrhea-predominant Irritable Bowel Syndrome-like Symptoms in Patients With Quiescent Crohn’s Disease: Comprehensive Analysis of Clinical Features and Intestinal Environment Including the Gut Microbiome, Organic Acids, and Intestinal Permeability
Toshihiko TOMITA ; Hirokazu FUKUI ; Daisuke MORISHITA ; Ayako MAEDA ; Yutaka MAKIZAKI ; Yoshiki TANAKA ; Hiroshi OHNO ; Tadayuki OSHIMA ; Hiroto MIWA
Journal of Neurogastroenterology and Motility 2023;29(1):102-112
Background/Aims:
Diarrhea-predominant irritable bowel syndrome (IBS-D)-like symptoms frequently occur in patients with quiescent Crohn’s disease (CD). To investigate the factors underlying IBS-D-like symptoms in patients with quiescent CD, we performed a comprehensive analysis of the clinical features and intestinal environment in those patients.
Methods:
We performed a prospective observational study of 27 patients with quiescent CD (CD activity index [CDAI] ≤ 150; C-reactive protein ≤ 0.3 mg/dL). The presence and severity of IBS-D-like symptoms, health-related quality of life, disease-specific quality of life, andstatus of depression and anxiety were evaluated. The level of intestinal permeability, fecal calprotectin and organic acids and the profiles of gut microbiome were analyzed.
Results:
Twelve of the 27 patients with quiescent CD (44.4%) had IBS-like symptoms, and these patients showed a significantly higher CDAI, IBS severity index and anxiety score than those without. The inflammatory bowel disease questionnaire score was significantly lower in the patients with IBS-D-like symptoms. There were no significant differences in small intestinal/colonic permeability or the levels of organic acids between the patients with and without IBS-D-like symptoms. Fusicatenibacter was significantly less abundant in the patients with IBS-D-like symptoms whereas their fecal calprotectin level was significantly higher (384.8 ± 310.6 mg/kg) than in patients without (161.0 ± 251.0 mg/kg). The receiver operating characteristic curve constructed to predict IBS-D-like symptoms in patients with quiescent CD using the fecal calprotectin level (cutoff, 125 mg/kg) showed a sensitivity and specificity of 73.3% and 91.7%, respectively.
Conclusion
Minimal inflammation is closely associated with the development of IBS-D-like symptoms in patients with quiescent CD.
6.Endocuff-Assisted versus Cap-Assisted Colonoscopy Performed by Trainees: A Retrospective Study
Yutaka OKAGAWA ; Tetsuya SUMIYOSHI ; Yusuke TOMITA ; Shutaro OIWA ; Fumihiro OGATA ; Takashi JIN ; Masahiro YOSHIDA ; Ryoji FUJII ; Takeyoshi MINAGAWA ; Kohtaro MORITA ; Hideyuki IHARA ; Michiaki HIRAYAMA ; Hitoshi KONDO
Clinical Endoscopy 2020;53(3):339-345
Background/Aims:
The adenoma detection rate (ADR) of screening colonoscopies performed by trainees is often lower than that of colonoscopies performed by experts. The effcacy of cap-assisted colonoscopy (CAC) in adenoma detection is well documented, especially that of CACs performed by trainees. Endocuff, a new endoscopic cap, is reportedly useful for adenoma detection; however, no trials have compared the effcacy of Endocuff-assisted colonoscopy (EAC) and CAC conducted by trainees. Therefore, the present study retrospectively compared the effcacy between EAC and CAC in trainees.
Methods:
This was a single-center, retrospective study involving 305 patients who underwent either EAC or CAC performed by three trainees between January and December 2018. We evaluated the ADR, mean number of adenomas detected per patient (MAP), cecal intubation rate, cecal intubation time, and occurrence of complications between the EAC and CAC groups.
Results:
The ADR was significantly higher in the EAC group than in the CAC group (54.3% vs. 37.3%, p=0.019), as was the MAP (1.36 vs. 0.74, p=0.003). No significant differences were found between the groups with respect to the cecal intubation rate or cecal intubation time. No major complications occurred in either group.
Conclusions
Our results suggest that EAC exhibits increased ADR and MAP compared to CAC when performed by trainees.