We report a case of sciatica showing improvement by treatment with Gorei-san-ryo. The patient, a 66-year-old woman with right gonarthrosis, had been receiving treatment at the orthopaedic surgery department since May 19, 2000. She felt left hip pain and left leg numbness on May 10, 2002. She was diagnosed with left-side sciatica on May 15, 2002. She was treated with loxoprofen, eperisone, and epidural steroids at the orthopaedic surgery, but her symptoms hardly improved. She visited our department on August 7, and treatment wiht Busi-to was begun. After four weeks, her symptoms had not improved. Busi-to was stopped and Gorei-san-ryo was begun on September 4. After two weeks, her hip pain had improved. Keishi-bukuryo-gan was administered in addition to Gorei-san-ryo on September 18. On December 25, her sciatica as evaluated by visual analogue scale, had decreased from 100 to 35 since first visiting our department. Based on this experience, it is suggested that Gorei-san-ryo be considered in the treatment of sciatica.