Objective To evaluate the diagnostic value of 18F-FDG PET/CT in patients with pancreatic neoplasm.Methods Fifty-three patients (36 males,17 females; age:(60.3±8.9) years) who underwent 18F-FDG PET/CT examination for suspected pancreatic tumor were retrospectively analyzed.Thirtytwo of them underwent dual-time point imaging.The characteristics of PET/CT images and serum CA19-9 were reviewed.Pathological results were used as a gold standard for evaluating the diagnostic value of PET/CT.Two-sample t test,paired t test and ROC curve analysis were used for data analysis.Results Thirtynine patients were finally diagnosed with pancreatic cancer and the other fourteen patients with benign disease.With SUVmax cutoff value of 3.13,the sensitivity and specificity of single-time point 18F-FDG PET/CT for diagnosis of pancreatic cancer were 92.3％ (36/39) and 9/14,respectively.The SUVmax was significant different between pancreatic cancer group and benign disease group (6.16±2.89 vs 3.37± 1.58; t =4.46,P＜0.01).Combined with the level of CA19-9,the diagnostic sensitivity and specificity were 69.2％ (27/39)and 13/14,respectively.The SUVmax of the early scan (5.45±2.43) was significantly different from that of the delayed scan (6.87±2.93) in pancreatic cancer group (t =8.25,P＜0.01),whereas no difference could be found in the benign group (3.18±1.28 vs 4.18±2.49; t=2.24,P＞0.05).With the SUVmax cutoff value of 3.3,the sensitivity,specificity and accuracy in the early scan were 87.0％ (20/23),6/9 and 81.2％ (26/32),respectively.While with the SUVmax cutoff value of 3.0,the sensitivity,specificity and accuracy in the delayed scan were 95.7％ (22/23),5/9 and 84.4％ (27/32),respectively.Conclusion 18 F-FDG PET/CT is a useful tool in the differential diagnosis of benign from malignant pancreatic diseases.

Twenty-six strains of Aeromonas hydrophila isolated in cultured fish and soft-shelled turtles were collected from various areas of China. Their susceptibilities to 21 antibacterial agents were studied by disc diffusion method. It was showed that all strains tcsted were resistant to pcnieillin and cephalosporins. Most of the strains were sensitive to norfloxacin, chloramphenicol and furazolidone, but up to 73.1%, 70. 1% and 50. 0% of strains tested showed resistance to sulfonamides, aminogylcosides and tetracyclines respectively. Meanwhile, their susceptibilities were examined by micro-dilution procedure against 8 commonly used antibacterials including ampicillin, furazolidone, teltracycline, oxytetracyeline ,steptomycin, chloramphenicol, sulfonamides and ciprofloxacin. Only two of 26 strains of A. hydrophila were sensitive to all drugs tested except ampicillin. The remaining 24 strains were resistant to various combinations of 8 drugs. Majority of the strains carried a marker of resistance to 2～3 drugs and highly sensitive to ciprofloxacin and chloramphenicol. The results indicated that A. hydrophila was highly resistant to most of common antibioties in China and more new antibacterials should be introduced into aquaculture to control ever-increasing fish diseases. The criterion for drug resistant bacteria was also discussed in this paper.

Twenty six strains of Aeromonas hydrophila isolated in cultured fish and soft shelled turtles were collected from various areas of China. Their susceptibilities to 21 antibacterial agents were studied by disc diffusion method. It was showed that all strains tcsted were resistant to pcnieillin and cephalosporins. Most of the strains were sensitive to norfloxacin, chloramphenicol and furazolidone, but up to 73.1%, 70.1% and 50.0% of strains tested showed resistance to sulfonamides, aminogylcosides and tetracyclines respectively. Meanwhile, their susceptibilities were examined by micro dilution procedure against 8 commonly used antibacterials including ampicillin, furazolidone, teltracycline, oxytetracyeline ,steptomycin, chloramphenicol, sulfonamides and ciprofloxacin. Only two of 26 strains of A. hydrophila were sensitive to all drugs tested except ampicillin. The remaining 24 strains were resistant to various combinations of 8 drugs. Majority of the strains carried a marker of resistance to 2～3 drugs and highly sensitive to ciprofloxacin and chloramphenicol. The results indicated that A. hydrophila was highly resistant to most of common antibioties in China and more new antibacterials should be introduced into aquaculture to control ever increasing fish diseases. The criterion for drug resistant bacteria was also discussed in this paper.