50 adult male SD rats were divided randomly into 5 groups:A,B,C1 ,C2,C3(n =1 0).The rats in roup A was used as a blank controls.The rats in group B and C were with LPS induced periodontitis,those in group C1 ,C2 and C3 received 0.2 ml of baicalin daily injection(0.01 ,0.1 and 1 .0 μg/ml respectively)into the gingival sulcus of the teeth with periodontitis for 3 days.The rats were sacri-ficed 7 days after treatment and periodontal tissues of the related teeth were observed by histology.In group C1 ,C2 and C3 the periodontal inflammation was significantly slighter than that in group B,the osteoclasts count was as following:B >C1 >C2 >C3 >A(P <0.05).The study suggests that baicalin can inhibit destructive effect of LPS to periodontal tissue of rats.
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