1.Prediction of susceptibility to acute mountain sickness based on LVQ neural-network model
Haiyan YOU ; Yuqi GAO ; Zhaohui HUANG
Journal of Regional Anatomy and Operative Surgery 2015;24(6):627-629
Objective The purpose of this study was to examine the relationship between acute mountain sickness ( AMS) and AMS susceptibility indices before ascent to high altitude and to evaluate their predictive value for AMS. Methods A total of 314 healthy male a-dults were voluntarily enrolled. Their 22 physiological and mental indices of AMS susceptibility were obtained before exposure high altitude. The diagnoses of AMS were based on the Lake Louise score ( LLS) ,an international standard scoring system for AMS. According to the char-acteristics of selected AMS susceptibility indices and the strong fault tolerance of neural network theory, the learning vector quantization ( LVQ) neural network method was adopted to build the prediction model of susceptibility to AMS. Results The results showed the sensitiv-ity of the LVQ model which distinguishes subjects with no-AMS reached 95. 00%,the average correct-prediction precision ultimately reached 72. 22%. The result of prediction is believable. Conclusion The builded LVQ model provide a scientific method for screening crowd who quickly ascend to high altitude,and also can lead to an effective preliminary screening of susceptibility to AMS.
2.Teaching strategies in pathophysiology teaching for nursing students in junior college
Zhibing YUAN ; Qingyuan HUANG ; Yuqi GAO
Chinese Journal of Medical Education Research 2013;(11):1125-1127
Nursing students in junior college have less class time and weaker foundation com-pared with nursing undergraduates, therefore it is more difficult for them to learn pathphysiology. In order to improve the teaching effect, we adopt the following strategies in pathophysiology teaching:①Guiding clinical nursing practice combining with specific situation in order to give students a deep understanding of pathophysiology knowledge and its significance. ②Urging students to review relevant basic knowledge before class and teacher to briefly introduce the basic knowledge before initiating class in order to reinforce the knowledge. ③Examples of daily life should be combined to make the abstract theory knowledge vivid. Teaching should revolve around the main line and key points should be highlighted. ④Dividing pathophysiology course into three units, and summary must be executed at the end of each unit.
3.Application of evidence-based support for targeted nursing in craniopharyngioma via transsphenoidal approach
Kangna ZHANG ; Na HUANG ; Yuqi GUO
Chinese Journal of Practical Nursing 2021;37(15):1158-1163
Objective:To explore the effect of targeted nursing with evidence-based support in the treatment of craniopharyngioma via the transsphenoidal approach.Methods:A total of 70 patients with craniopharyngiomas who were admitted to the Department of Oncology of Beijing Tiantan Hospital, Capital Medical University from June 2018 to June 2019 were selected and all received transsphenoidal surgery in the hospital. The patients were divided into 2 groups according to the lottery method, 35 cases in the control group, using conventional nursing; 35 cases in the observation group, using targeted care with evidence-based support; comparing the two groups of patients before and after care, the incidence of complications, and the length of hospital stay.Results:The scores of anxiety and depression (6.05±1.24 and 5.78±1.48) in the observation group 2 weeks after nursing were lower than those in the control group (9.95±1.73 and 10.52±1.87). The difference was statistically significant ( t value was 10.036, 10.886, P<0.05). The postoperative high fever, electrolyte imbalance, diabetes insipidus, epilepsy remission time and hospital stay in the observation group were (5.49±0.84)h, (5.46±0.39)d, (1.03±0.21)h, (6.24±2.78)d, (12.51±1.48)d, which were shorter than those in the control group (8.78±1.05)h, (8.51±0.47)d, (2.49±0.35)h, (8.97±2.80)d, (15.26±1.52)d. The difference was statistically significant ( t value were 4.093-29.545, P<0.05). The incidence of postoperative complications in the observation group was 17.14% (6/35), which was lower than 37.14% (13/35) in the control group, and the difference was statistically significant ( χ2 value was 4.786, P=0.029). Conclusion:Targeted nursing with evidence-based support can reduce the incidence of postoperative complications in patients with craniopharyngioma through the transsphenoidal approach, shorten the length of hospital stay, and achieve significant application results.
4.Distribution and Resistance of Bacteria Inducing Clinical Infection
Yuqi OUYANG ; Qiang HUANG ; Fusheng YAN
Chinese Journal of Nosocomiology 2006;0(05):-
OBJECTIVE To investigate the distribution and drug resistance of the bacteria encountered from the(clinical) infection,and provide reference for the rational use of agents in clinics.METHODS To culture the(specimens) from inpatient and outpatient clinic from Dec 2004 to Mar 2005,and perform the drug (sensitivity) test.RESULTS In 1584 isolated strains,the first four were coagulase negative Staphylococcus((15.6%),) Klebsiella(13.0%),Escherichia coli(10.0%),and Candida albicans(9.9%).The highest resistance of Gram(-negative) bacilli was to ampicillin(86.7%),then to cephalothin(79.5%),and mezlocillin(75.7%);G~-bacilli were(sensitive) to meropenem(2.3%),piperacillin/tazobactam(19.0%),and fosfomycin(29.1%).Gram~+ cocci had drug(resistance) to 18 antibacterials except vancomycin,MRSA was higher than MSSA;(Enterococcus) faecium showed poor sensitive rate to penicillin and erythromycin.CONCLUSIONS We should give more attantion to the Rules on Antibacterials in Clinical Application and use drugs reasonably.
5.Course reform and thinking of the experimental teaching of pharmaceutical technology based on the case teaching
Xuemei LIU ; Yuqi HUANG ; Guojian LIAO ; Changhua HU
Chinese Journal of Medical Education Research 2016;15(3):248-251
The experimental teaching of Pharmaceutical Technology plays a critical role in improving the students' knowledge conversion,application,and innovation abilities in pharmaceutical engineering specialty.According to the problems existing in experimental teaching process,exploration and practice on the case teaching method and the student-centered teaching mode are introduced in this paper.The implementation of the teaching reform can effectively combine pharmaceutical technology theory with practice,and is conducive to the professional development of pharmaceutical engineering in our university.
6.Effect of early normobaric hyperoxia on cerebral oxygenation in patients with extremely severe craniocerebral injury
Xuri SUN ; Yuqi LIU ; Guoliang TAN ; Sibai HONG ; Tinglong HUANG
Chinese Journal of Trauma 2014;30(12):1172-1175
Objective To observe the changes of brain oxygenation in patients with extremely severe craniocerebral injury and the therapeutic effect of early normobaric hyperoxia.Methods Sixtyeight patients with extremely severe craniocerebral injury treated from January 2011 to January 2013 were assigned to two groups according to the random number table:50% oxygen breathing for one week in control group (34 cases) and 80% oxygen breathing for one week in treatment group (34 cases).Blood samples from jugular vein and radial artery were collected at 1,3,5,and 7 days to measure indices of blood gas analysis,i.e.,PaO2,PjvO2,CaO2,CjvO2,Da-jvO2,CERO2 and Djv-a Lac.GCS and content of neuron-specific enolase (NSE) were recorded as well.Results Values of PaO2 at each time point and GCS at 5 and 7 days were significantly higher in treatment group than in control group (P <0.05).Djv-a Lac at 3,5 and 7 days and NSE at 7 days revealed significantly higher levels in treatment group than in control group(P < 0.05).Whereas at each time point,there were no significant differences between the two groups in aspects of PjvO2,CaO2,CjvO2,Da-jvO2 and CERO2 (P > 0.05).Conclusion Early use of 100% oxygen in patients with extremely severe craniocerebral injury may be beneficial to the prognosis.
7.Proteomic study on skeletal muscle mitochondrial proteins of chronic hypoxic Wistar rats
Wenxiang GAO ; Jian CHEN ; Yuqi GAO ; Jian HUANG
Chinese Journal of Pathophysiology 1986;0(03):-
AIM: To explore hypoxia-related mitochondrial proteins in Wistar rats exposed to chronic hypobaric hypoxia.METHODS: Adult male Wistar rats were randomized into chronic hypoxia (30 d) group and control group. Bilateral gastrocnemius were collected and mitochondria were extracted and purified for two dimensional electrophoresis (2-DE) and matrix assisted laser desorption/ionization mass spectrometry (MALDI-TOF-MS) analysis.RESULTS: Compared to the control, 35 protein spots in chronic hypoxia group were up-regulated (8 protein spots) or down-regulated (27 protein spots), 8 of which were identified as F1-ATPase alpha subunit, voltage-dependent anion channel 1, androgen regulated protein, tripartite motif protein 50, hydroxyacyl-coenzyme A dehydrogenase alpha subunit and mitochondrial F1 complex gamma subunit.CONCLUSION: Our results suggest that hypoxia exposure may affect mitochondrial electron transport chain, oxidative phosphorylation and lipid metabolism.
8.Bamboo-circled Salt-partitioned Moxibustion for Arthritis of Temporomandibular Joint: A Randomized Controlled Clinical Trial
Zhihua HUANG ; Kaisheng XU ; Jinqing ZHENG ; Yuqi HE ; Feng WU
Shanghai Journal of Acupuncture and Moxibustion 2017;36(2):180-183
Objective To observe the clinical efficacy of bamboo-circled salt-partitioned moxibustion in treating arthritis of temporomandibular joint.Method Eighty patients were randomized into two groups. Forty cases in the bamboo-circled salt-partitioned moxibustion group received bamboo-circled salt-partitioned moxibustion at temporomandibular joint; forty cases in the warm needling group were intervened by selecting Xiaguan (ST7), Ashi point, etc. at the affected side. For the two groups, 3-day treatment was taken as a treatment course, and the therapeutic efficacy was analyzed after 2 treatment courses. The improvements in pain and mouth opening were observed before and after the treatment, and the treatment efficacy was evaluated by a 1-month follow-up study.Result The bamboo-circled salt-partitioned moxibustion group was superior to the warm needling group in comparing the real-time analgesic effect (P<0.05) and in the improvement of mouth opening (P<0.05); the comprehensive markedly effective rate was respectively 67.5% and 45.0% in the bamboo-circled salt-partitioned moxibustion group and warm needling group, and the between-group difference was statistically significant (P<0.05), indicating that bamboo-circled salt-partitioned moxibustion is better than warm needling in treating arthritis of temporomandibular joint; the follow-up study revealed satisfactory therapeutic efficacies in both groups: the effective rate was 92.5% in the bamboo-circled salt-partitioned moxibustion group versus 87.5% in the warm needling group, and the difference was statistically insignificant (P>0.05).Conclusion Bamboo-circled salt-partitioned moxibustion can produce a real-time analgesic effect and improve mouth opening; it's especially suitable to treat the patients who are afraid of needling, as it's significantly effective, safe, non-invasive,and easy-to-operate.
9.Protective roles of hypobaric hypoxic pretreatment on hippocampus neurons in mice
Youming FAN ; Yuqi GAO ; Fuyu LIU ; Jian HUANG ; Weigong LIAO
Chinese Journal of Pathophysiology 1986;0(01):-
AIM: This study was designed to investigate the protective role of hypobaric hypoxic pretreatment (HHPT) on hippocampal neurons in Babl/c inbred mice. METHODS: HHPT was produced by simulating a 7 000 m high altitude 2.5 h/d for 3 d. At 36 h after last time decompression, three subgroups consisted of both the control and pretreatment mice were subjected to the 12 000 m high altitude hypobaric hypoxia for 4 h, the severe ischemia produced by bilateral common carotid artery occlusion for 18 min, and the severe ischemia/hypoxia produced by permanently ligation of right lateral common carotid artery followed by a 8 000 m high altitude hypobaric hypoxia for 4 h, respectively. The extents of protection to hippocampal CA1 neurons by HHPT were evaluated by accounting the number of intact neurons between HHPT and control group. RESULTS: The results indicated that HHPT protected hippocampal neurons against severe hypobaric hypoxia, severe ischemia, and ischemia combined with hypobaric hypoxia. CONCLUSION: Hypobaric hypoxic pretreatment induces a delayed protection to hippocampal neurons against hypoxic and ischemic injuries.
10.Combination therapy with single inhaler of long-acting β2-adrenoceptor agonists/inlaled corticosteroids compared with higher dose of inhaled corticosteroids in asthmatic patients
Hongtao LI ; Tiantuo ZHANG ; Yuqi ZHOU ; Hui LIU ; Jing HUANG
Chinese Journal of Primary Medicine and Pharmacy 2012;19(2):218-221
Objective To provide a quantitative summary estimate on the efficacy and safety measures of the combination therapy.Methods We searched databases(Medline and Embase)from January 1997 to December 2009 using‘ Fluticasone and salmerterol' or‘ Seretide' or‘ Advair' or‘ budesonide/formoterol' or‘ Symbicort Turbuhaler' in combination with ‘ Randomised controlled trial'.The databases of GlaxoSmithKline Clinical Trial Register and Cochrane Controlled Trials Register,or relevant original studies and review articles were approached for additional studies or details of all relevant studies.Results Morning peak expiratory flow(PEF),evening PEF and clinic FEV1 were 17.59L/min,14.95L/min and 0.08L/min higher with combination therpy than with increasing ICSs by two fold or more at endpoint,respectively.The risk of asthmatic exacerbation was reduced in the combination therpy group compared with the increased doses of ICS groups,with OR being 0.61(95 % CI 0.53 ~ 0.70,P < 0.01).Significantly increases in the percent of symptom-free days 6.30(95% CI 3.52 ~9.10),asthma-control days 9.49(95% CI 4.74 ~14.25)and relieve-free days 6.59(95% CI 6.10 ~ 7.08)were observed in patients treated with ICS/LABA compared with increased doses of ICSs at endpoint.Reduction in reliever medication use(inhalations/day)0.22(95 % CI 0.11 ~0.33)with significant difference was also observed at endpoint.Conclusion Combination products of ICS/LABA were more effective than a high dose of ICSs in improving lung function,reducing asthmatic exacerbation and use of reliever medication and improving control of asthma.