1.Primary study of the tongue squamous cell carcinoma treated with targeting and continuous interstitial chemotherapy
Yunze XUAN ; Jianguo ZHANG ; Jie ZHANG
Journal of Practical Stomatology 1996;0(02):-
Objective:To observe the efficacy and side effect of targeting and continuous interstitial chemotherapy in the treatment of tongue squamous cell carcinoma.Methods:Sustain-released cisplatin(20 mg/piece) was implanted into and around tongue squamous cell carcinoma in 10 cases,20 mg was used for the tumor at T1,40 mg for T2 and 60 mg for T3.7~10 days after implantation tumor resection was performed,the efficacy and side effect were observed.Results:The size of all tumor were reduced,50%-60% reduction was observed in 8 cases. Pathological examination of after-operation samples showed cancer cell necrosis in the center, and the degeneration and necrosis in the peripheral tissues where the drug had been implanted in.Necrosis and tissue degeneration could be seen in the metastasized lymph nodes.The side effects were local pain,hyperemia and edema in all the cases.Slight high temperature and nausea were observed in a few cases.Conclusion:The sustain-released cisplatin implanted into lesions is effective for the treatment of squamous cell carcinoma of the tongue with no severe side effects.
2.Effect of preoperative interstitial chemotherapy on Ki-67 and Caspase-3 in oral squamous cell carcinoma
Bin JIN ; Yunze XUAN ; Jingxu LI ; Guangze JIN ; Runguo WU
Chongqing Medicine 2014;(14):1707-1709
Objective To discuss the preoperative interstitial chemotherapy effect and significance on Ki‐67 and Caspase‐3 in oral squamous cell carcinoma .Methods 60 cases of well‐differentiated oral squamous cell carcinoma were divided into three groups ,non chemotherapy before operation group(n= 30) ,intravenous chemotherapy before operation group (n= 15) and interstitial chemo‐therapy before operation group(n=15) .The expressions of Ki‐67 and Caspase‐3 were determined by immunohistochemical method , then compared between three groups .Results The labelling index of Ki‐67 in tissue of carcinoma were significant differences a‐mong each groups(P< 0 .05) .The labelling index of Ki‐67 in adjacent mucosas of carcinoma were significant differences among three groups(P<0 .05) .The expression rates of Caspase‐3 were significant differences among three groups(P<0 .05) .Conclusion Preoperative interstitial chemotherapy than preoperative intravonous chemotherapy for oral squamous carcinoma more inhibit tumor growth and reduce local recurrence through the inhibition of cell proliferation and induction of cell apoptosis ,thus inhibiting tumor growth .
3.Study of drug distribution in tissue during treatment with targeting and continuous interstitial chemotherapy in the oral squamous cell carcinoma
Yunze XUAN ; Lei ZHENG ; Jianguo ZHANG ; Jie ZHANG ; Yan GAO
Journal of Practical Stomatology 2000;0(05):-
Objective:To study the drug distribution in the local tissues and lymph nodes treated with targeting and continuous interstitial chemotherapy for the oral squamous cell carcinoma before operation. Methods:8 patients with oral squamous cell carcinoma were treated by implanting the sustain-released cisplatin around and into the primary lesion. Drug distribution in tissue were studied by the graphite furnace atomic absorption spectrometry. Results:The drug concentration in the center of the tumor,1 cm and 2 cm from the tumor fringe were (34.877 1?15.720 8),(20.690 0 ?15.688 6) and (6.635 7?3.862 3) ?g/g, respectively. The drug concentration within lymph nodes of the sub-mental and submandibular area, deep cervical lymph nodes for the upper,middle and lower were(2.991 4?3.055 7),(4.026 0 ?3.692 0), (7.192 0 ? 8.958 7) and (5.028 5?3.484 3)?g/g, respectively. Conclusion:Targeting and continuous interstitial chemotherapy for the oral squamous cell carcinoma by implanting sustain-released cisplatin can increase drug concentration in the local tissues and the lymph nodes, to attain good efficacy of targeting chemotherapy.
4.Expert consensus on cryoablation therapy of oral mucosal melanoma
Guoxin REN ; Moyi SUN ; Zhangui TANG ; Longjiang LI ; Jian MENG ; Zhijun SUN ; Shaoyan LIU ; Yue HE ; Wei SHANG ; Gang LI ; Jie ZHNAG ; Heming WU ; Yi LI ; Shaohui HUANG ; Shizhou ZHANG ; Zhongcheng GONG ; Jun WANG ; Anxun WANG ; Zhiyong LI ; Zhiquan HUNAG ; Tong SU ; Jichen LI ; Kai YANG ; Weizhong LI ; Weihong XIE ; Qing XI ; Ke ZHAO ; Yunze XUAN ; Li HUANG ; Chuanzheng SUN ; Bing HAN ; Yanping CHEN ; Wenge CHEN ; Yunteng WU ; Dongliang WEI ; Wei GUO
Journal of Practical Stomatology 2024;40(2):149-155
Cryoablation therapy with explicit anti-tumor mechanisms and histopathological manifestations has a long history.A large number of clinical practice has shown that cryoablation therapy is safe and effective,making it an ideal tumor treatment method in theory.Previously,its efficacy and clinical application were constrained by the limitations of refrigerants and refrigeration equipment.With the development of the new generation of cryoablation equipment represented by argon helium knives,significant progress has been made in refrigeration efficien-cy,ablation range,and precise temperature measurement,greatly promoting the progression of tumor cryoablation technology.This consensus systematically summarizes the mechanism of cryoablation technology,indications for oral mucosal melanoma(OMM)cryotherapy,clinical treatment process,adverse reactions and management,cryotherapy combination therapy,etc.,aiming to provide reference for carrying out the standardized cryoablation therapy of OMM.