1.The development and clinical application of high-efficiency and new-type microwave internal cavity radiator
Yiqiang MIAO ; Yunya GAO ; Juexian ZHANG ; Honsen QIAN
Chinese Journal of Medical Physics 2000;17(4):229-230,234
For raising the efficiency of microwave radiation, reducing radiating dosage and shortening therapeutic time, the key is to design a new type and high effective microwave radiator. This paper describes the improvement and clinical effect of the new internal cavity radiator and circular cervical radiator. These two typies of radiator are wisely used in the hospitals. They have been marked therapeutics effects.
2.The incidence of Mycobacterium tuberculosis infection among human immunodeficiency virus-infected individuals in Shanghai and Yunnan Province
Xinyun ZHANG ; Yan GAO ; Lingyun SHAO ; Yunya XU ; Weimin JIANG ; Wenhong ZHANG
Chinese Journal of Infectious Diseases 2014;32(10):585-588
Objective To investigate the incidence of Mycobacterium tuberculosis (TB) infection among human immunodeficiency virus (HIV)-infected individuals in Shanghai and Yunnan Province and to analyze the risk factors of TB infection.Methods Seventy HIV-infected individuals from Yunnan Province and 67 from Shanghai were enrolled.T-SPOT.TB was employed to detect TB-specific T cells in the peripheral blood mononuclear cells (PBMC).CD4+ and CD8+ T cells in PBMC from the enrolled subjects were detected by flow cytometry.Data were analyzed using Mann-Whitney test,Fisher's exact test and Logistic regression.Results The incidence of latent tuberculosis (LTB) infection among HIV-infected individuals in Yunnan Province was 64.3 % (45/70),which was much higher than Shanghai (20.8% [14/ 67]).The median CD4+ T cell count of HIV-infected individuals with LTB infection in Yunnan Province was 509/μL,while that in Shanghai was 324/μL,which was significant different (U=148,P=0.003).The median CD4+ T cell count in HIV single infected individuals from Yunnan Province was 418/μL,which was not significantly different from that of H IV + LTB individuals from that area (U =378,P =0.120).Moreover,the median CD8+ T cell counts of HIV-infected individuals with latent tuberculosis infection in Yunnan Province and Shanghai were 409/μL and 781/μL,respectively (U=109,P<0.01).Conclusions The incidence of LTB infection among HIV-infected individuals in Yunnan Province is significantly higher than Shanghai.CD4+ and CD8+ T cell counts are correlated with TB infection among HIV-infected individuals.
3.Evaluation of safety of two inactivated COVID-19 vaccines in a large-scale emergency use
Zhongnan YANG ; Yunya ZHAO ; Lu LI ; Huidi GAO ; Qi CAI ; Xiaoxia SUN ; Fusheng ZHANG ; Jinfeng SU ; Yinan ZHANG ; Xiang SHU ; Xuewei WANG ; Yunkai YANG ; Yuntao ZHANG ; Song ZHOU ; Xiaoming YANG
Chinese Journal of Epidemiology 2021;42(6):977-982
Objective:To evaluate the safety of two inactivated COVID-19 vaccines in a large-scale emergency use.Methods:Based on the "Vaccination Information Collection System", the incidence data of adverse reactions in the population vaccinated with the inactivated COVID-19 vaccines developed by Beijing Institute of Biological Products Co., Ltd and Wuhan Institute of Biological Products Co., Ltd, respectively, in emergency use were collected, and the relevant information were analyzed with descriptive epidemiological and statistical methods.Results:By December 1, 2020, the vaccination information of 519 543 individuals had been collected. The overall incidence rate of adverse reactions was 1.06%, the incidence rate of systemic adverse reactions was 0.69% and the incidence rate of local adverse reactions was 0.37%. The main systemic adverse reactions included fatigue, headache, fever, cough and loss of appetite with the incidence rates of 0.21%, 0.14%, 0.06%, 0.05% and 0.05%, respectively; the main local adverse reactions were injection site pain and injection site swelling with the incidence rates of 0.24% and 0.05%, respectively.Conclusion:The two inactivated COVID-19 vaccines by Beijing Institute of Biological Products Co., Ltd and Wuhan Institute of Biological Products Co., Ltd showed that in the large-scale emergency use, the incidence rate of general reactions was low and no serious adverse reactions were observed after the vaccinations, demonstrating that the vaccines have good safety.