In order to analyze main influencing factors of exportation of Chinese traditional patent medicines to the EU and measure the potentialities, the panel data of the exportation of Chinese traditional patent medicines to 13 countries in the EU over the period from 2000 to 2011 were used to build a regression model. Then, this model was applied to estimate the export potentialities. The results showed that the GDPs of China and EU countries, the export prices of Chinese traditional patent medicines, the port capacities of EU countries and maritime distances between ports of two countries notably promote export trade. At the same time, unified standards of pesticide residue analysis are associated with reducing the volume of export trade. EU countries can be divided into two groups. One is the group with certain potentiality. The other is the group without ready potentiality. Suggestions were made on basis of research results in order to promote exportation of Chinese traditional patent medicines to the EU.

OBJECTIVE:To study the percutaneous properties of Man-PEI25k nanocomplex under the treatment of microneedles. METHODS:Using fluorescent dye water-soluble carboxyl CdSe/ZnS quantum dot (QD) as model drug, Man-PEI25k/QD and Man-PEI25k/QD nanocomplex with different grafting rates(1∶3,1∶6)were formed through electrostatic adherence with PEI25k and Man-PEI25k. The distribution of QD in the active epidermal layer and dermis of skin were observed by confocal microscopy after the treatment of microneedles,using free QD as control. The accumulative retention amounts of QD in the active epidermal layer and dermis of skin were determined by fluorescence spectrophotometer after PEI25k/QD and Man-PEI25k/QD nanocomplex treated with mi-croneedles. RESULTS:The amounts of Man-PEI25k/QD nanocomplex in active epidermal layer and dermis were significantly higher than that of PEI25k/QD nanocomplex under the treatment of microneedles in vivo;the amounts of Man-PEI25k/QD (1∶6) nanocom-plex in active epidermal layer and dermis of skin were significantly higher than that of Man-PEI25k/QD(1∶3)nanocomplex. In in vi-tro transdermal diffusion experiments,microneedles could increase the retention amounts of nanocomplex in active epidermal layer and dermis of skin significantly. The retention amounts of Man-PEI25k/QD nanocomplex in active epidermal layer were increased by 2 times of that of PEI25k/QD under the treatment of microneedles after 48 h;at the same time,in the dermis that was increased by 1.5 times,with statistical significance (P<0.01). CONCLUSIONS:Microneedles can improve the percutaneous properties of Man-PEI25k nanocomplex in active epidermal layer.